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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F14%3A10283783%21RIV15-MSM-11150___
rdf:type
n17:Vysledek skos:Concept
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0306987714001352
dcterms:description
Multipotent mesenchymal stromal cells (MSCs) are primitive cells capable of restoring damaged mesenchyme and with the ability to differentiate into mature cells of bone, cartilage, muscle, fat, nerve or fibrous tissues. MSCs are therefore good candidates for applications in regenerative medicine and cell based therapy. They regenerate through self-renewal, differentiational capacity, immune modulation and secretion of bioactive molecules. Authors present a review of MSCs applications in otorhinolaryngology. The major interest is focused on phonosurgery, sensorineural deafness and reconstruction of large tissue defects with bone, cartilage or soft tissue replacement. Current evidence of MSCs treatment efficacy in otorhinolaryngology is based on animal models. The true impact on clinical treatment will not be known until clinical studies prove functional outcomes in human medicine. Multipotent mesenchymal stromal cells (MSCs) are primitive cells capable of restoring damaged mesenchyme and with the ability to differentiate into mature cells of bone, cartilage, muscle, fat, nerve or fibrous tissues. MSCs are therefore good candidates for applications in regenerative medicine and cell based therapy. They regenerate through self-renewal, differentiational capacity, immune modulation and secretion of bioactive molecules. Authors present a review of MSCs applications in otorhinolaryngology. The major interest is focused on phonosurgery, sensorineural deafness and reconstruction of large tissue defects with bone, cartilage or soft tissue replacement. Current evidence of MSCs treatment efficacy in otorhinolaryngology is based on animal models. The true impact on clinical treatment will not be known until clinical studies prove functional outcomes in human medicine.
dcterms:title
Multipotent mesenchymal stromal cells in otorhinolaryngology Multipotent mesenchymal stromal cells in otorhinolaryngology
skos:prefLabel
Multipotent mesenchymal stromal cells in otorhinolaryngology Multipotent mesenchymal stromal cells in otorhinolaryngology
skos:notation
RIV/00216208:11150/14:10283783!RIV15-MSM-11150___
n3:aktivita
n18:I
n3:aktivity
I
n3:cisloPeriodika
6
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
n7:8438854 n7:6321704 n7:9990801 n7:7677251
n3:druhVysledku
n19:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
31104
n3:idVysledku
RIV/00216208:11150/14:10283783
n3:jazykVysledku
n15:eng
n3:klicovaSlova
cartilage replacement; bone replacement; otorhinolaryngology; mesenchymal stromal cells
n3:klicoveSlovo
n4:cartilage%20replacement n4:otorhinolaryngology n4:bone%20replacement n4:mesenchymal%20stromal%20cells
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[1341528ECCBB]
n3:nazevZdroje
Medical Hypotheses
n3:obor
n9:FF
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n14:2014
n3:svazekPeriodika
82
n3:tvurceVysledku
Kalfeřt, David Filip, Stanislav Kočí, Zuzana Chrobok, Viktor Školoudík, Lukáš
n3:wos
000336704200028
s:issn
0306-9877
s:numberOfPages
5
n8:doi
10.1016/j.mehy.2014.03.022
n11:organizacniJednotka
11150