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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F14%3A10283122%21RIV15-MSM-11150___
rdf:type
n10:Vysledek skos:Concept
rdfs:seeAlso
http://cardiologyacademicpress.com/soap/pdf/delme_2420_5450664627eff3.57643395.pdf
dcterms:description
Objective The aim of retrospective, single center study is to assess frequency of mitral regurgitation (MR) in systemic sclerosis (SSc) patients in relevance with left ventricular (LV) diastolic and systolic dysfunction and clinical parameters. Methods58 patients (13 men, 45 women, the mean age was 62.0 +- 12.2 years) were recruited with a diagnosis of SSc (AmericanCollege of Rheumatology) within a 10-year follow -up. Demographic, clinical data and Doppler echocardiography were obtained according to standard procedures. Results In comparison with a control group (patients undergoing screening echocardiography before chemotherapy), grade 3-4/4 and grade 1-4/4 of MR were observed in 8 (13.8%;p=0.028)and 28 (48.3%;p=0.148) patients respectively. Data analysis showed positive association of MR grade 3-4/4 with lower LV ejection fraction (p=0.003) and tendency to negative association with %22peak velocity of the early inflow phase/ peak velocity of the atrial inflow phase%22 (E/A) ratio <1 (0% versus 40%;p=0.09) in comparison with patients without MR. Conclusion This study showed high frequency of MR in patients with SSc, mainly grade 3-4/4. SSc is associated with higher prevalence of diastolic dysfunction characterized by E/A ratio inversion. Normalization of E/A may signalize worsening or development of MR. Objective The aim of retrospective, single center study is to assess frequency of mitral regurgitation (MR) in systemic sclerosis (SSc) patients in relevance with left ventricular (LV) diastolic and systolic dysfunction and clinical parameters. Methods58 patients (13 men, 45 women, the mean age was 62.0 +- 12.2 years) were recruited with a diagnosis of SSc (AmericanCollege of Rheumatology) within a 10-year follow -up. Demographic, clinical data and Doppler echocardiography were obtained according to standard procedures. Results In comparison with a control group (patients undergoing screening echocardiography before chemotherapy), grade 3-4/4 and grade 1-4/4 of MR were observed in 8 (13.8%;p=0.028)and 28 (48.3%;p=0.148) patients respectively. Data analysis showed positive association of MR grade 3-4/4 with lower LV ejection fraction (p=0.003) and tendency to negative association with %22peak velocity of the early inflow phase/ peak velocity of the atrial inflow phase%22 (E/A) ratio <1 (0% versus 40%;p=0.09) in comparison with patients without MR. Conclusion This study showed high frequency of MR in patients with SSc, mainly grade 3-4/4. SSc is associated with higher prevalence of diastolic dysfunction characterized by E/A ratio inversion. Normalization of E/A may signalize worsening or development of MR.
dcterms:title
The screening of mitral regurgitation in patients with systemic sclerosis The screening of mitral regurgitation in patients with systemic sclerosis
skos:prefLabel
The screening of mitral regurgitation in patients with systemic sclerosis The screening of mitral regurgitation in patients with systemic sclerosis
skos:notation
RIV/00216208:11150/14:10283122!RIV15-MSM-11150___
n3:aktivita
n15:I
n3:aktivity
I
n3:cisloPeriodika
10
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
n4:3594734 n4:4805607 n4:9453806 n4:1363093 n4:9496548
n3:druhVysledku
n13:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
43949
n3:idVysledku
RIV/00216208:11150/14:10283122
n3:jazykVysledku
n18:eng
n3:klicovaSlova
echocardiography; systemic sclerosis; mitral regurgitation
n3:klicoveSlovo
n5:mitral%20regurgitation n5:echocardiography n5:systemic%20sclerosis
n3:kodStatuVydavatele
CA - Kanada
n3:kontrolniKodProRIV
[2DCD75688881]
n3:nazevZdroje
Experimental and Clinical Cardiology
n3:obor
n16:FE
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n14:2014
n3:svazekPeriodika
20
n3:tvurceVysledku
Kubínová, Kateřina Hromádková, Lucie Pudil, Radek Soukup, Tomáš Dušek, Jaroslav Tomš, Jan
s:issn
1205-6626
s:numberOfPages
7
n17:organizacniJednotka
11150