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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F14%3A10282807%21RIV15-MSM-11150___
rdf:type
n9:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1159/000368467
dcterms:description
Background/Aims: The aim of our study was to retrospectively analyse data of 520 Czech patients with IgA nephropathy (IgAN) and to specify the risk factors affecting renal survival of IgAN patients. Methods: Cox proportional hazards regression model was used to evaluate the effects of different variables on renal survival during a median follow up of six years. McNemar's test was used to analyse the progression of renal function according to Bartosik's formula. Results: In our retrospective analysis of 520 Czech IgAN patients Cox proportional hazards regression model with five variables [hypertension, sex, GFR, proteinuria, age] was used. Significant regression coefficient was found for GFR, hypertension and proteinuria. Using stepwise algorithm GFR (OR = 3.09), hypertension (OR = 2.09) and proteinuria (OR = 1.97) were found as the most important factors for renal survival in our group of IgAN patients. Among patients with CKD 3 we found significantly better renal survival in patients with proteinuria < 1g/day compared to patients with higher proteinuria. We did not find the significant difference between predicted progression of renal function due to Bartosik's formula and real progression of renal parametres assessed by GFR at the end of the follow up in our group of IgAN patients. Conclusion: Our retrospective study of 520 Czech IgAN patients confirmed GFR, hypertension and proteinuria as the most important factors affecting the prognosis of IgAN patients. We validated Toronto Bartosik's formula to predict prognosis of IgAN patients. Background/Aims: The aim of our study was to retrospectively analyse data of 520 Czech patients with IgA nephropathy (IgAN) and to specify the risk factors affecting renal survival of IgAN patients. Methods: Cox proportional hazards regression model was used to evaluate the effects of different variables on renal survival during a median follow up of six years. McNemar's test was used to analyse the progression of renal function according to Bartosik's formula. Results: In our retrospective analysis of 520 Czech IgAN patients Cox proportional hazards regression model with five variables [hypertension, sex, GFR, proteinuria, age] was used. Significant regression coefficient was found for GFR, hypertension and proteinuria. Using stepwise algorithm GFR (OR = 3.09), hypertension (OR = 2.09) and proteinuria (OR = 1.97) were found as the most important factors for renal survival in our group of IgAN patients. Among patients with CKD 3 we found significantly better renal survival in patients with proteinuria < 1g/day compared to patients with higher proteinuria. We did not find the significant difference between predicted progression of renal function due to Bartosik's formula and real progression of renal parametres assessed by GFR at the end of the follow up in our group of IgAN patients. Conclusion: Our retrospective study of 520 Czech IgAN patients confirmed GFR, hypertension and proteinuria as the most important factors affecting the prognosis of IgAN patients. We validated Toronto Bartosik's formula to predict prognosis of IgAN patients.
dcterms:title
IgA Nephropathy in Czech Patients - Are We Able Reliably Predict the Outcome? IgA Nephropathy in Czech Patients - Are We Able Reliably Predict the Outcome?
skos:prefLabel
IgA Nephropathy in Czech Patients - Are We Able Reliably Predict the Outcome? IgA Nephropathy in Czech Patients - Are We Able Reliably Predict the Outcome?
skos:notation
RIV/00216208:11150/14:10282807!RIV15-MSM-11150___
n3:aktivita
n14:I
n3:aktivity
I
n3:cisloPeriodika
6
n3:dodaniDat
n17:2015
n3:domaciTvurceVysledku
n19:7995962
n3:druhVysledku
n11:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
20423
n3:idVysledku
RIV/00216208:11150/14:10282807
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Prognosis; ESRD; Risk factors; IgA nephropathy
n3:klicoveSlovo
n6:IgA%20nephropathy n6:Prognosis n6:ESRD n6:Risk%20factors
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[FACF42588E30]
n3:nazevZdroje
Kidney and Blood Pressure Research
n3:obor
n12:FE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
11
n3:rokUplatneniVysledku
n17:2014
n3:svazekPeriodika
39
n3:tvurceVysledku
Tesař, Vladimír Maixnerová, Dita Skibová, Jelena Mokrišová, Jana Ryšavá, Romana Zadražil, Josef Jančová, Eva Merta, Miroslav Neprašová, Michaela Honsová, Eva Reiterová, Jana
n3:wos
000347728100006
s:issn
1420-4096
s:numberOfPages
8
n7:doi
10.1159/000368467
n16:organizacniJednotka
11150