This HTML5 document contains 52 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n18http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216208%3A11150%2F14%3A10282721%21RIV15-MSM-11150___/
n10http://localhost/temp/predkladatel/
n13http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n6http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
rdfshttp://www.w3.org/2000/01/rdf-schema#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n12http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n15http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n7http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n19http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n14http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F14%3A10282721%21RIV15-MSM-11150___
rdf:type
n6:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1515/cclm-2013-0162
dcterms:description
Background: Epigenetic changes are considered to be a frequent event during tumor development. Various methylation changes have been identified and show promise as potential cancer biomarkers. The aim of this study was to investigate promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium. Methods: To search for promoter methylation of GATA4 and TP53 genes we used methylation-specific PCR (MSP) to compare the methylation status of 54 patients with endometrioid carcinoma of endometrium and 18 patients with normal endometrial tissue. Results: In our study MSP revealed GATA4 promoter methylation in 44 of 54 in the carcinoma group (81.5%), and in none of the control group. No methylation was observed in TP53 gene. Conclusions: In conclusion, our study showed that there is significantly higher methylation in GATA4 gene in the endometrial cancer group compared with samples of nonneoplastic endometrium. The finding suggests the importance of hypermethylation of this gene in endometrial carcinogenesis and could have implications for future diagnostic and therapeutic strategies for endometrial cancer based on epigenetic changes. Background: Epigenetic changes are considered to be a frequent event during tumor development. Various methylation changes have been identified and show promise as potential cancer biomarkers. The aim of this study was to investigate promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium. Methods: To search for promoter methylation of GATA4 and TP53 genes we used methylation-specific PCR (MSP) to compare the methylation status of 54 patients with endometrioid carcinoma of endometrium and 18 patients with normal endometrial tissue. Results: In our study MSP revealed GATA4 promoter methylation in 44 of 54 in the carcinoma group (81.5%), and in none of the control group. No methylation was observed in TP53 gene. Conclusions: In conclusion, our study showed that there is significantly higher methylation in GATA4 gene in the endometrial cancer group compared with samples of nonneoplastic endometrium. The finding suggests the importance of hypermethylation of this gene in endometrial carcinogenesis and could have implications for future diagnostic and therapeutic strategies for endometrial cancer based on epigenetic changes.
dcterms:title
Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium
skos:prefLabel
Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium
skos:notation
RIV/00216208:11150/14:10282721!RIV15-MSM-11150___
n3:aktivita
n19:I
n3:aktivity
I
n3:cisloPeriodika
8
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
n13:2010887 n13:8934460 Kos, Špela n13:6953891 n13:1117149
n3:druhVysledku
n4:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
20927
n3:idVysledku
RIV/00216208:11150/14:10282721
n3:jazykVysledku
n17:eng
n3:klicovaSlova
methylation; gene TP53; GATA4 transcription factor; epigenomics; endometrial neoplasms
n3:klicoveSlovo
n15:GATA4%20transcription%20factor n15:gene%20TP53 n15:endometrial%20neoplasms n15:methylation n15:epigenomics
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[77F5E034D26D]
n3:nazevZdroje
Clinical Chemistry and Laboratory Medicine
n3:obor
n16:EB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n14:2014
n3:svazekPeriodika
52
n3:tvurceVysledku
Špaček, Jiří Chmelařová, Marcela Ruszová, Ema Palička, Vladimír Kos, Špela Laco, Jan Dvořáková, Eva Hrochová, Kateřina
n3:wos
000340786100026
s:issn
1434-6621
s:numberOfPages
6
n12:doi
10.1515/cclm-2013-0162
n10:organizacniJednotka
11150