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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F14%3A10282579%21RIV15-MSM-11150___
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1007/s00428-014-1591-9
dcterms:description
Some renal epithelial neoplasms, such as renal angiomyoadenomatous tumor, clear cell papillary renal cell carcinoma and renal cell carcinoma with smooth muscle stroma, contain a variably prominent smooth muscle stromal component. Whether or not this leiomyomatous stroma is part of the neoplastic proliferation has not been firmly established. We studied the clonality status of 14 renal cell carcinomas with a prominent smooth muscle stromal component (four renal angiomyoadenomatous tumors/clear cell papillary carcinomas, five clear cell carcinomas, two papillary carcinomas, and three renal cell carcinomas with smooth muscle rich stroma) using the human androgen receptor assay (HUMARA). We found the leiomyomatous stromal component in all analyzable (8/14) cases to be polyclonal and therefore reactive rather than neoplastic. Based on morphological observations, we propose that the non-neoplastic leiomyomatous stromal component is likely derived from smooth muscle cells of large caliber veins located at the peripheral capsular region or within the collagenous septae of the tumors. Some renal epithelial neoplasms, such as renal angiomyoadenomatous tumor, clear cell papillary renal cell carcinoma and renal cell carcinoma with smooth muscle stroma, contain a variably prominent smooth muscle stromal component. Whether or not this leiomyomatous stroma is part of the neoplastic proliferation has not been firmly established. We studied the clonality status of 14 renal cell carcinomas with a prominent smooth muscle stromal component (four renal angiomyoadenomatous tumors/clear cell papillary carcinomas, five clear cell carcinomas, two papillary carcinomas, and three renal cell carcinomas with smooth muscle rich stroma) using the human androgen receptor assay (HUMARA). We found the leiomyomatous stromal component in all analyzable (8/14) cases to be polyclonal and therefore reactive rather than neoplastic. Based on morphological observations, we propose that the non-neoplastic leiomyomatous stromal component is likely derived from smooth muscle cells of large caliber veins located at the peripheral capsular region or within the collagenous septae of the tumors.
dcterms:title
The leiomyomatous stroma in renal cell carcinomas is polyclonal and not part of the neoplastic process The leiomyomatous stroma in renal cell carcinomas is polyclonal and not part of the neoplastic process
skos:prefLabel
The leiomyomatous stroma in renal cell carcinomas is polyclonal and not part of the neoplastic process The leiomyomatous stroma in renal cell carcinomas is polyclonal and not part of the neoplastic process
skos:notation
RIV/00216208:11150/14:10282579!RIV15-MSM-11150___
n4:aktivita
n18:S n18:I
n4:aktivity
I, S
n4:cisloPeriodika
1
n4:dodaniDat
n12:2015
n4:domaciTvurceVysledku
n11:1239570
n4:druhVysledku
n16:J
n4:duvernostUdaju
n8:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
25955
n4:idVysledku
RIV/00216208:11150/14:10282579
n4:jazykVysledku
n15:eng
n4:klicovaSlova
Reactive stroma; HUMARA; Stroma origin; Leiomyomatous stroma; Renal cell carcinoma; Kidney
n4:klicoveSlovo
n5:Leiomyomatous%20stroma n5:Renal%20cell%20carcinoma n5:Stroma%20origin n5:Kidney n5:HUMARA n5:Reactive%20stroma
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[9284BE984C4F]
n4:nazevZdroje
Virchows Archiv : an international journal of pathology
n4:obor
n7:FP
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
21
n4:rokUplatneniVysledku
n12:2014
n4:svazekPeriodika
465
n4:tvurceVysledku
Korabečná, Marie Kruslin, Bozo Kokošková, Bohuslava Rychly, Boris Hes, Ondřej Podhola, Miroslav Martínek, Petr Suster, Saul Petersson, Fredrik Pivovarčíková, Kristýna Sperga, Maris Bauleth, Kevin Michal, Michal Bulimbasic, Stela Rotterova, Pavla Branžovský, Jindřich Pecková, Květoslava Hora, Milan Trivunic, Sandra Švajdler, Marián Leroy, Xavier
n4:wos
000338728000010
s:issn
0945-6317
s:numberOfPages
8
n17:doi
10.1007/s00428-014-1591-9
n13:organizacniJednotka
11150