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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F14%3A10281272%21RIV15-MSM-11150___
rdf:type
n13:Vysledek skos:Concept
rdfs:seeAlso
http://www.tumorionline.it/r.php?v=1636&a=17886&l=26486&f=allegati/01636_2014_04/fulltext/01-Filipova%20363-369.pdf
dcterms:description
Breast cancer is the most common type of malignant disease in women worldwide. In developing countries the past few years have sustained an increasing incidence of this type of cancer. Currently, breast cancer is the second leading cause of death due to cancer in women. In 2008 alone it was diagnosed in more than 1 million patients and each year the number of breast cancer-related deaths is estimated to be ~450,000. The mortality rate in breast cancer patients has been decreasing over the years thanks to the development of early diagnostic methods and more effective treatments. But despite the new advances in cancer diagnosis and treatment, the risk of recurrence and metastasis is ever present. It has been theorized that cancer stem cells are involved in the process of tumor growth and metastases. Due to their self-renewing and differentiation capabilities, they are now considered the underlying factor in tumor recurrence and the main reason for therapy resistance. Therefore, the characterization of cancer stem cells may contribute to the development of more effective treatment strategies that should make it possible to eliminate cancer stem cells in order to prevent tumor relapse and metastasis in diagnosed patients. Breast cancer is the most common type of malignant disease in women worldwide. In developing countries the past few years have sustained an increasing incidence of this type of cancer. Currently, breast cancer is the second leading cause of death due to cancer in women. In 2008 alone it was diagnosed in more than 1 million patients and each year the number of breast cancer-related deaths is estimated to be ~450,000. The mortality rate in breast cancer patients has been decreasing over the years thanks to the development of early diagnostic methods and more effective treatments. But despite the new advances in cancer diagnosis and treatment, the risk of recurrence and metastasis is ever present. It has been theorized that cancer stem cells are involved in the process of tumor growth and metastases. Due to their self-renewing and differentiation capabilities, they are now considered the underlying factor in tumor recurrence and the main reason for therapy resistance. Therefore, the characterization of cancer stem cells may contribute to the development of more effective treatment strategies that should make it possible to eliminate cancer stem cells in order to prevent tumor relapse and metastasis in diagnosed patients.
dcterms:title
Breast cancer and cancer stem cells: a mini-review Breast cancer and cancer stem cells: a mini-review
skos:prefLabel
Breast cancer and cancer stem cells: a mini-review Breast cancer and cancer stem cells: a mini-review
skos:notation
RIV/00216208:11150/14:10281272!RIV15-MSM-11150___
n3:aktivita
n17:I n17:P
n3:aktivity
I, P(EE2.3.30.0022)
n3:cisloPeriodika
4
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
n5:6518672 Diaz Garcia, Daniel n5:6628249 n5:9990801 n5:4433319 n5:6452965
n3:druhVysledku
n16:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
5789
n3:idVysledku
RIV/00216208:11150/14:10281272
n3:jazykVysledku
n18:eng
n3:klicovaSlova
niche; metastasis; stem cells; cancer; Breast cancer
n3:klicoveSlovo
n9:niche n9:cancer n9:Breast%20cancer n9:stem%20cells n9:metastasis
n3:kodStatuVydavatele
IT - Italská republika
n3:kontrolniKodProRIV
[99BEE9E15A9A]
n3:nazevZdroje
Tumori
n3:obor
n8:FD
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
7
n3:projekt
n10:EE2.3.30.0022
n3:rokUplatneniVysledku
n14:2014
n3:svazekPeriodika
100
n3:tvurceVysledku
Filip, Stanislav Filipová, Alžběta Řezáčová, Martina Seifrtová, Martina Dvořák, Josef Mokrý, Jaroslav Diaz Garcia, Daniel
n3:wos
000348335300001
s:issn
0300-8916
s:numberOfPages
7
n19:doi
10.1700/1636.17886
n6:organizacniJednotka
11150