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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F14%3A10277413%21RIV15-MSM-11150___
rdf:type
skos:Concept n19:Vysledek
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0378427414013290
dcterms:description
Effects of chronic exposure to supranutritional sodium selenite (Se) were investigated in colonic fibroblasts. Initially, Se did not produce any gross changes in exposed cells; however, basal levels of autophagy were transiently increased and p38 activity was stimulated. From the 3rd week onwards, Se decreased cell proliferation, with corrensponding changes in cell cycle distribution. Also, in exposed cells oxidative stress and DNA damage slowly but gradually increased along with decreasing mitochondrial function and upon continued elevated activity of p38 kinase. Towards the end of the experiment, premature senescence features became more prominent in treated cells. Pharmacological inhibition as well as gene knockdown of these processes confirmed the involvement of p38 in balancing autophagy and premature senescence in cells exposed to Se and suggests that this element may in a given time frame compromise selected cell populations in digestive system. Effects of chronic exposure to supranutritional sodium selenite (Se) were investigated in colonic fibroblasts. Initially, Se did not produce any gross changes in exposed cells; however, basal levels of autophagy were transiently increased and p38 activity was stimulated. From the 3rd week onwards, Se decreased cell proliferation, with corrensponding changes in cell cycle distribution. Also, in exposed cells oxidative stress and DNA damage slowly but gradually increased along with decreasing mitochondrial function and upon continued elevated activity of p38 kinase. Towards the end of the experiment, premature senescence features became more prominent in treated cells. Pharmacological inhibition as well as gene knockdown of these processes confirmed the involvement of p38 in balancing autophagy and premature senescence in cells exposed to Se and suggests that this element may in a given time frame compromise selected cell populations in digestive system.
dcterms:title
Activation of p38 and changes in mitochondria accompany autophagy to premature senescence-like phenotype switch upon chronic exposure to selenite in colon fibroblasts Activation of p38 and changes in mitochondria accompany autophagy to premature senescence-like phenotype switch upon chronic exposure to selenite in colon fibroblasts
skos:prefLabel
Activation of p38 and changes in mitochondria accompany autophagy to premature senescence-like phenotype switch upon chronic exposure to selenite in colon fibroblasts Activation of p38 and changes in mitochondria accompany autophagy to premature senescence-like phenotype switch upon chronic exposure to selenite in colon fibroblasts
skos:notation
RIV/00216208:11150/14:10277413!RIV15-MSM-11150___
n3:aktivita
n13:I
n3:aktivity
I
n3:cisloPeriodika
1
n3:dodaniDat
n10:2015
n3:domaciTvurceVysledku
n7:2650673 n7:1249746 n7:7364202
n3:druhVysledku
n14:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
1514
n3:idVysledku
RIV/00216208:11150/14:10277413
n3:jazykVysledku
n8:eng
n3:klicovaSlova
p38; Sodium selenite; Premature senescence; Mitochondria; Colonic fibroblasts; Autophagy
n3:klicoveSlovo
n4:Mitochondria n4:p38 n4:Autophagy n4:Sodium%20selenite n4:Premature%20senescence n4:Colonic%20fibroblasts
n3:kodStatuVydavatele
IE - Irsko
n3:kontrolniKodProRIV
[94F39F59ACA4]
n3:nazevZdroje
Toxicology Letters
n3:obor
n11:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n10:2014
n3:svazekPeriodika
231
n3:tvurceVysledku
Řezáčová, Kateřina Rudolf, Emil Červinka, Miroslav
n3:wos
000344696100004
s:issn
0378-4274
s:numberOfPages
9
n5:doi
10.1016/j.toxlet.2014.09.006
n15:organizacniJednotka
11150