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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F14%3A10271918%21RIV15-MSM-11150___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
When diagnosing primary aldosteronism, the measurement of urinary aldosterone after oral sodium loading is one of the currently recommended confirmatory tests. The aim of the study was to assess the repeatability and interpretation of urinary aldosterone in patients examined for suspected primary aldosteronism. Sixty-four hypertensive patients with suspected primary aldosteronism were prospectively enrolled and examined according to the study protocol. After antihypertensive medications interfering with renin-angiotensin-aldosterone system were withdrawn for at least 2 weeks, the confirmatory testing was performed: oral sodium loading preceded the collection of 24-h urine sample and subsequent saline infusion test. The identical procedures were repeated after 2 weeks. The concordant results of both saline infusion tests served for confirmation/exclusion of primary aldosteronism. Forty-nine patients were included in data analysis. Primary aldosteronism was excluded in 16, and confirmed in 33 individuals. The repeatability of urinary aldosterone was evaluated in 44 patients: the difference of urinary aldosterone levels ranged between 1 and 88% (median 31%). Ninety-three urine samples from 49 patients were used to validate the interpretation of urinary aldosterone in respect to the diagnosis of primary aldosteronism made by saline infusion testing; 96% sensitivity was characterized by urinary aldosterone GREATER-THAN OR EQUAL TO19 nmol/day, and 96% specificity was associated with urinary aldosterone GREATER-THAN OR EQUAL TO92 nmol/day. In 22 (45%) patients, urinary aldosterone remained in the %22gray%22 zone between 19 and 92 nmol/day in all provided samples. The estimation of urinary aldosterone excretion after oral sodium loading is associated with marked intraindividual variability, and significant number of inconclusive results. When diagnosing primary aldosteronism, the measurement of urinary aldosterone after oral sodium loading is one of the currently recommended confirmatory tests. The aim of the study was to assess the repeatability and interpretation of urinary aldosterone in patients examined for suspected primary aldosteronism. Sixty-four hypertensive patients with suspected primary aldosteronism were prospectively enrolled and examined according to the study protocol. After antihypertensive medications interfering with renin-angiotensin-aldosterone system were withdrawn for at least 2 weeks, the confirmatory testing was performed: oral sodium loading preceded the collection of 24-h urine sample and subsequent saline infusion test. The identical procedures were repeated after 2 weeks. The concordant results of both saline infusion tests served for confirmation/exclusion of primary aldosteronism. Forty-nine patients were included in data analysis. Primary aldosteronism was excluded in 16, and confirmed in 33 individuals. The repeatability of urinary aldosterone was evaluated in 44 patients: the difference of urinary aldosterone levels ranged between 1 and 88% (median 31%). Ninety-three urine samples from 49 patients were used to validate the interpretation of urinary aldosterone in respect to the diagnosis of primary aldosteronism made by saline infusion testing; 96% sensitivity was characterized by urinary aldosterone GREATER-THAN OR EQUAL TO19 nmol/day, and 96% specificity was associated with urinary aldosterone GREATER-THAN OR EQUAL TO92 nmol/day. In 22 (45%) patients, urinary aldosterone remained in the %22gray%22 zone between 19 and 92 nmol/day in all provided samples. The estimation of urinary aldosterone excretion after oral sodium loading is associated with marked intraindividual variability, and significant number of inconclusive results.
dcterms:title
The Role of Urinary Aldosterone for the Diagnosis of Primary Aldosteronism The Role of Urinary Aldosterone for the Diagnosis of Primary Aldosteronism
skos:prefLabel
The Role of Urinary Aldosterone for the Diagnosis of Primary Aldosteronism The Role of Urinary Aldosterone for the Diagnosis of Primary Aldosteronism
skos:notation
RIV/00216208:11150/14:10271918!RIV15-MSM-11150___
n4:aktivita
n9:I
n4:aktivity
I
n4:cisloPeriodika
9
n4:dodaniDat
n13:2015
n4:domaciTvurceVysledku
n14:7414854 n14:3677958 n14:4472136
n4:druhVysledku
n6:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
43213
n4:idVysledku
RIV/00216208:11150/14:10271918
n4:jazykVysledku
n18:eng
n4:klicovaSlova
secondary arterial hypertension; urinary aldosterone; primary aldosteronism
n4:klicoveSlovo
n8:urinary%20aldosterone n8:secondary%20arterial%20hypertension n8:primary%20aldosteronism
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[EF5246C6FA50]
n4:nazevZdroje
Hormone and Metabolic Research
n4:obor
n10:FE
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
4
n4:rokUplatneniVysledku
n13:2014
n4:svazekPeriodika
46
n4:tvurceVysledku
Ceral, Jiří Malířová, Eva Ballon, Marek Solař, Miroslav
n4:wos
000341100000011
s:issn
0018-5043
s:numberOfPages
5
n11:doi
10.1055/s-0034-1374638
n12:organizacniJednotka
11150