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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F14%3A10271859%21RIV15-MSM-11150___
rdf:type
n7:Vysledek skos:Concept
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1111/jpi.12154/pdf
dcterms:description
Melatonin was previously shown to reduce blood pressure and left ventricular remodeling in several models of experimental heart damage. Isoproterenol-induced heart failure with hypertrophy of the left and right ventricles, lowered systolic blood pressure and elevated pulmonary congestion. Fibrotic rebuilding was accompanied by alterations of tubulin level in the LV and oxidative stress development. Melatonin failed to reduce the weight of the LV or RV; however, it curtailed the weight of the lungs and attenuated the decline in SBP. Moreover, melatonin decreased the level of oxidative stress and insoluble and total collagen. Most importantly, melatonin reduced mortality and prolonged the average survival time. In conclusion, melatonin exerts cardioprotective effects and improves outcome in a model of isoproterenol-induced heart damage. Melatonin was previously shown to reduce blood pressure and left ventricular remodeling in several models of experimental heart damage. Isoproterenol-induced heart failure with hypertrophy of the left and right ventricles, lowered systolic blood pressure and elevated pulmonary congestion. Fibrotic rebuilding was accompanied by alterations of tubulin level in the LV and oxidative stress development. Melatonin failed to reduce the weight of the LV or RV; however, it curtailed the weight of the lungs and attenuated the decline in SBP. Moreover, melatonin decreased the level of oxidative stress and insoluble and total collagen. Most importantly, melatonin reduced mortality and prolonged the average survival time. In conclusion, melatonin exerts cardioprotective effects and improves outcome in a model of isoproterenol-induced heart damage.
dcterms:title
Melatonin reduces cardiac remodeling and improves survival in rats with isoproterenol-induced heart failure Melatonin reduces cardiac remodeling and improves survival in rats with isoproterenol-induced heart failure
skos:prefLabel
Melatonin reduces cardiac remodeling and improves survival in rats with isoproterenol-induced heart failure Melatonin reduces cardiac remodeling and improves survival in rats with isoproterenol-induced heart failure
skos:notation
RIV/00216208:11150/14:10271859!RIV15-MSM-11150___
n3:aktivita
n6:I
n3:aktivity
I
n3:cisloPeriodika
2
n3:dodaniDat
n16:2015
n3:domaciTvurceVysledku
n13:7344856
n3:druhVysledku
n12:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
28242
n3:idVysledku
RIV/00216208:11150/14:10271859
n3:jazykVysledku
n11:eng
n3:klicovaSlova
remodeling; mortality; melatonin; isoproterenol; heart hypertrophy; heart failure; fibrosis
n3:klicoveSlovo
n4:mortality n4:heart%20hypertrophy n4:isoproterenol n4:fibrosis n4:heart%20failure n4:melatonin n4:remodeling
n3:kodStatuVydavatele
DK - Dánské království
n3:kontrolniKodProRIV
[9C0F4689E1CF]
n3:nazevZdroje
Journal of Pineal Research
n3:obor
n18:ED
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n16:2014
n3:svazekPeriodika
57
n3:tvurceVysledku
Hrenak, Jaroslav Šimko, Fedor Repová-Bednárová, Kristina Celec, Peter Krajčirovičová, Kristina Gajdosechová, Lucia Kamodyová, Natalia Adamcová, Michaela Zorad, Štefan
n3:wos
000342234000005
s:issn
0742-3098
s:numberOfPages
8
n9:doi
10.1111/jpi.12154
n5:organizacniJednotka
11150