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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F14%3A10227362%21RIV15-MSM-11150___
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://www.karger.com/Article/FullText/355957
dcterms:description
Common variable immunodeficiency (CVID) is the most frequent clinically relevant primary immunodeficiency and shows enormous heterogeneity in clinical presentation. Despite clinical immunodeficiency, opportunistic infections are not a typical manifestation of CVID. A retrospective study of 32 patients followed up for 335 patient-years was performed to determine the frequency of cytomegalovirus (CMV) disease. Symptomatic CMV infection was documented in 3 CVID patients. Patients No. 1 and 2 suffered from CMV pneumonia, with complications due to atypical mycobacteriosis in patient No. 1. Patient No. 3 suffered from CMV enteritis. A history of cancer and chronic hepatitis C infection (patient No. 1), immunosuppressive therapy for interstitial lung disease (patient No. 2) and serious enteropathy complicated with malnutrition (patient No. 3) may have contributed to the complications despite only mild abnormalities in T-cell subpopulations. The direct detection of CMV in bronchoalveolar lavage, stool or tissue samples was the most beneficial diagnostic laboratory method, whereas the detection of CMV DNA in blood did not produce positive results. Adequate treatment of CMV disease led to significant clinical improvement in all 3 patients. The frequency of CMV disease appears to be higher than previously described. In our experience, the probability of opportunistic infections in CVID patients increases with secondary comorbidities and their management. Common variable immunodeficiency (CVID) is the most frequent clinically relevant primary immunodeficiency and shows enormous heterogeneity in clinical presentation. Despite clinical immunodeficiency, opportunistic infections are not a typical manifestation of CVID. A retrospective study of 32 patients followed up for 335 patient-years was performed to determine the frequency of cytomegalovirus (CMV) disease. Symptomatic CMV infection was documented in 3 CVID patients. Patients No. 1 and 2 suffered from CMV pneumonia, with complications due to atypical mycobacteriosis in patient No. 1. Patient No. 3 suffered from CMV enteritis. A history of cancer and chronic hepatitis C infection (patient No. 1), immunosuppressive therapy for interstitial lung disease (patient No. 2) and serious enteropathy complicated with malnutrition (patient No. 3) may have contributed to the complications despite only mild abnormalities in T-cell subpopulations. The direct detection of CMV in bronchoalveolar lavage, stool or tissue samples was the most beneficial diagnostic laboratory method, whereas the detection of CMV DNA in blood did not produce positive results. Adequate treatment of CMV disease led to significant clinical improvement in all 3 patients. The frequency of CMV disease appears to be higher than previously described. In our experience, the probability of opportunistic infections in CVID patients increases with secondary comorbidities and their management.
dcterms:title
Cytomegalovirus Disease in Patients with Common Variable Immunodeficiency: Three Case Reports Cytomegalovirus Disease in Patients with Common Variable Immunodeficiency: Three Case Reports
skos:prefLabel
Cytomegalovirus Disease in Patients with Common Variable Immunodeficiency: Three Case Reports Cytomegalovirus Disease in Patients with Common Variable Immunodeficiency: Three Case Reports
skos:notation
RIV/00216208:11150/14:10227362!RIV15-MSM-11150___
n3:aktivita
n20:P n20:I
n3:aktivity
I, P(ED1.1.00/02.0068)
n3:cisloPeriodika
1
n3:dodaniDat
n12:2015
n3:domaciTvurceVysledku
n6:1561537 n6:6725856 n6:2086867 n6:9063374 n6:5524237 n6:3608670
n3:druhVysledku
n8:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
9557
n3:idVysledku
RIV/00216208:11150/14:10227362
n3:jazykVysledku
n10:eng
n3:klicovaSlova
enteritis; pneumonitis; opportunistic infection; mycobacteriosis; cytomegalovirus; common variable immunodeficiency
n3:klicoveSlovo
n4:common%20variable%20immunodeficiency n4:cytomegalovirus n4:opportunistic%20infection n4:enteritis n4:pneumonitis n4:mycobacteriosis
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[9CFD10412B63]
n3:nazevZdroje
International Archives of Allergy and Immunology
n3:obor
n13:FN
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
12
n3:projekt
n19:ED1.1.00%2F02.0068
n3:rokUplatneniVysledku
n12:2014
n3:svazekPeriodika
163
n3:tvurceVysledku
Tachecí, Ilja Malá, Eva Bartoš, Vladimír Krčmová, Irena Králíčková, Pavlína Vokurková, Doris Brožík, Jan Plíšková, Lenka Koblížek, Vladimír Štěpánová, Vlasta Bureš, Jan Litzman, Jiří
n3:wos
000329603200012
s:issn
1018-2438
s:numberOfPages
6
n15:doi
10.1159/000355957
n18:organizacniJednotka
11150