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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F14%3A10227254%21RIV15-MSM-11150___
rdf:type
n11:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.4149/neo_2014_039
dcterms:description
The primary cilium is a solitary, sensory, non-motile microtubule-based structure that arises from the centrosome and is projected from the surface of most human cells. The objective of the current pilot study was to conduct an investigation of presence and frequency of cilia in gastrointestinal stromal tumors (GIST). The presence of primary cilia in GIST was evaluated in 9 patients, including 8 primary tumors and 1 liver metastasis. In 2 patients the presence of primary cilia was evaluated not only in the primary tumor, but also in recurrence: in 1 patient in recurrence without previous treatment with imatinib and in 1 patient in recurrence after treatment with imatinib. The primary cilia of GIST cells were immunofluorescently stained with primary monoclonal anti-acetylated tubulin alpha antibody and cell nuclei with DAPI. We observed 9985 nuclei of cells of GISTs and 425 primary cilia in total. The median of frequency of primary cilia in cells of GISTs in all examined samples was 4.26%, in primary tumors was 4.32% and in metastases was 3.64%, respectively. This pilot study provides the evidence of the presence of primary cilia in GISTs in different organs. Primary cilia were identified in all examined cases of GIST, including primary tumors, metastases and recurrent lesions without and with previous treatment with imatinib. The primary cilium is a solitary, sensory, non-motile microtubule-based structure that arises from the centrosome and is projected from the surface of most human cells. The objective of the current pilot study was to conduct an investigation of presence and frequency of cilia in gastrointestinal stromal tumors (GIST). The presence of primary cilia in GIST was evaluated in 9 patients, including 8 primary tumors and 1 liver metastasis. In 2 patients the presence of primary cilia was evaluated not only in the primary tumor, but also in recurrence: in 1 patient in recurrence without previous treatment with imatinib and in 1 patient in recurrence after treatment with imatinib. The primary cilia of GIST cells were immunofluorescently stained with primary monoclonal anti-acetylated tubulin alpha antibody and cell nuclei with DAPI. We observed 9985 nuclei of cells of GISTs and 425 primary cilia in total. The median of frequency of primary cilia in cells of GISTs in all examined samples was 4.26%, in primary tumors was 4.32% and in metastases was 3.64%, respectively. This pilot study provides the evidence of the presence of primary cilia in GISTs in different organs. Primary cilia were identified in all examined cases of GIST, including primary tumors, metastases and recurrent lesions without and with previous treatment with imatinib.
dcterms:title
Primary cilia in gastrointestinal stromal tumors Primary cilia in gastrointestinal stromal tumors
skos:prefLabel
Primary cilia in gastrointestinal stromal tumors Primary cilia in gastrointestinal stromal tumors
skos:notation
RIV/00216208:11150/14:10227254!RIV15-MSM-11150___
n4:aktivita
n19:I
n4:aktivity
I
n4:cisloPeriodika
3
n4:dodaniDat
n16:2015
n4:domaciTvurceVysledku
n5:6210554 n5:4433319 n5:3421805 n5:5290791 n5:1141147 n5:4769007 n5:9990801 n5:8120765 n5:6628249
n4:druhVysledku
n6:J
n4:duvernostUdaju
n8:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
39340
n4:idVysledku
RIV/00216208:11150/14:10227254
n4:jazykVysledku
n14:eng
n4:klicovaSlova
recurrence; imatinib; primary cilia; GIST
n4:klicoveSlovo
n17:primary%20cilia n17:imatinib n17:recurrence n17:GIST
n4:kodStatuVydavatele
SK - Slovenská republika
n4:kontrolniKodProRIV
[532CA11ACC6B]
n4:nazevZdroje
Neoplasma
n4:obor
n13:FD
n4:pocetDomacichTvurcuVysledku
9
n4:pocetTvurcuVysledku
11
n4:rokUplatneniVysledku
n16:2014
n4:svazekPeriodika
61
n4:tvurceVysledku
Richter, Igor Dvořák, Josef Ryška, Aleš Melichar, Bohuslav Petera, Jiří Filip, Stanislav Filipová, Alžběta Buka, David Mokrý, Jaroslav Hadži Nikolov, Dimitar Sitorová, Veronika
n4:wos
000336515000009
s:issn
0028-2685
s:numberOfPages
4
n10:doi
10.4149/neo_2014_039
n15:organizacniJednotka
11150