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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F14%3A10209641%21RIV15-MSM-11150___
rdf:type
n12:Vysledek skos:Concept
rdfs:seeAlso
http://link.springer.com/article/10.1007%2Fs11011-013-9428-9
dcterms:description
The article provides evidence that a vicious cycle in glutamine synthesis and breakdown among tissues with high levels of glutamine synthetase (skeletal muscle, brain) and glutaminase (enetrocytes, kidneys) is activated in liver failure. These alterations may explain why therapies targeted to intestinal bacteria have only a limited effect on ammonia levels in patients with liver failure and indicate the needs of new therapeutic strategies focused on glutamine metabolism. The positive and adverse effects of various nutritional and pharmacological strategies focused on glutamine metabolism in treatment of hyperammonemia and hepatice encephalopathy are discussed in the second part of the article. Attention is given to glutamine, glutamate, alpha-ketoglutarate, branched-chain amino acids, glutaminase inhibitors, and phenylbutyrate. The article provides evidence that a vicious cycle in glutamine synthesis and breakdown among tissues with high levels of glutamine synthetase (skeletal muscle, brain) and glutaminase (enetrocytes, kidneys) is activated in liver failure. These alterations may explain why therapies targeted to intestinal bacteria have only a limited effect on ammonia levels in patients with liver failure and indicate the needs of new therapeutic strategies focused on glutamine metabolism. The positive and adverse effects of various nutritional and pharmacological strategies focused on glutamine metabolism in treatment of hyperammonemia and hepatice encephalopathy are discussed in the second part of the article. Attention is given to glutamine, glutamate, alpha-ketoglutarate, branched-chain amino acids, glutaminase inhibitors, and phenylbutyrate.
dcterms:title
Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy-thereapeutic perspectives Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy-thereapeutic perspectives
skos:prefLabel
Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy-thereapeutic perspectives Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy-thereapeutic perspectives
skos:notation
RIV/00216208:11150/14:10209641!RIV15-MSM-11150___
n4:aktivita
n9:I
n4:aktivity
I
n4:cisloPeriodika
1
n4:dodaniDat
n13:2015
n4:domaciTvurceVysledku
n16:3031624
n4:druhVysledku
n8:J
n4:duvernostUdaju
n5:S
n4:entitaPredkladatele
n6:predkladatel
n4:idSjednocenehoVysledku
15548
n4:idVysledku
RIV/00216208:11150/14:10209641
n4:jazykVysledku
n15:eng
n4:klicovaSlova
phenylbutyrate; glutamine; branched-chain amino acids; liver; Ammonia
n4:klicoveSlovo
n11:phenylbutyrate n11:Ammonia n11:liver n11:branched-chain%20amino%20acids n11:glutamine
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[1D63F1965192]
n4:nazevZdroje
Metabolic Brain Disease
n4:obor
n17:ED
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
1
n4:rokUplatneniVysledku
n13:2014
n4:svazekPeriodika
29
n4:tvurceVysledku
Holeček, Milan
n4:wos
000331965900002
s:issn
0885-7490
s:numberOfPages
9
n19:doi
10.1007/s11011-013-9428-9
n3:organizacniJednotka
11150