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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F14%3A10189919%21RIV15-MSM-11150___
rdf:type
skos:Concept n19:Vysledek
rdfs:seeAlso
http://www.mdpi.com/1422-0067/15/1/1647
dcterms:description
Hair follicle morphogenesis depends on Wnt, Shh, Notch, BMP and other signaling pathways interplay between epithelial and mesenchymal cells. The Wnt pathway plays an essential role during hair follicle induction, Shh is involved in morphogenesis and late stage differentiation, Notch signaling determines stem cell fate while BMP is involved in cellular differentiation. The Wnt pathway is considered to be the master regulator during hair follicle morphogenesis. Wnt signaling proceeds through EDA/EDAR/NF-kappa B signaling. NF-kappa B regulates the Wnt pathway and acts as a signal mediator by upregulating the expression of Shh ligand. Signal crosstalk between epithelial and mesenchymal cells takes place mainly through primary cilia. Primary cilia formation is initiated with epithelial laminin-511 interaction with dermal beta-1 integrin, which also upregulates expression of downstream effectors of Shh pathway in dermal lineage. PDGF signal transduction essential for crosstalk is mediated through epithelial PDGF-A and PDGFR alpha expressed on the primary cilia. Dermal Shh and PDGF signaling up-regulates dermal noggin expression; noggin is a potent inhibitor of BMP signaling which helps in counteracting BMP mediated beta-catenin inhibition. This interplay of signaling between the epithelial and dermal lineage helps in epithelial Shh signal amplification. The dermal Wnt pathway helps in upregulation of epithelial Notch expression. Dysregulation of these pathways leads to certain abnormalities and in some cases even tumor outgrowth. Hair follicle morphogenesis depends on Wnt, Shh, Notch, BMP and other signaling pathways interplay between epithelial and mesenchymal cells. The Wnt pathway plays an essential role during hair follicle induction, Shh is involved in morphogenesis and late stage differentiation, Notch signaling determines stem cell fate while BMP is involved in cellular differentiation. The Wnt pathway is considered to be the master regulator during hair follicle morphogenesis. Wnt signaling proceeds through EDA/EDAR/NF-kappa B signaling. NF-kappa B regulates the Wnt pathway and acts as a signal mediator by upregulating the expression of Shh ligand. Signal crosstalk between epithelial and mesenchymal cells takes place mainly through primary cilia. Primary cilia formation is initiated with epithelial laminin-511 interaction with dermal beta-1 integrin, which also upregulates expression of downstream effectors of Shh pathway in dermal lineage. PDGF signal transduction essential for crosstalk is mediated through epithelial PDGF-A and PDGFR alpha expressed on the primary cilia. Dermal Shh and PDGF signaling up-regulates dermal noggin expression; noggin is a potent inhibitor of BMP signaling which helps in counteracting BMP mediated beta-catenin inhibition. This interplay of signaling between the epithelial and dermal lineage helps in epithelial Shh signal amplification. The dermal Wnt pathway helps in upregulation of epithelial Notch expression. Dysregulation of these pathways leads to certain abnormalities and in some cases even tumor outgrowth.
dcterms:title
Signaling Involved in Hair Follicle Morphogenesis and Development Signaling Involved in Hair Follicle Morphogenesis and Development
skos:prefLabel
Signaling Involved in Hair Follicle Morphogenesis and Development Signaling Involved in Hair Follicle Morphogenesis and Development
skos:notation
RIV/00216208:11150/14:10189919!RIV15-MSM-11150___
n3:aktivita
n6:P n6:I
n3:aktivity
I, P(EE2.3.30.0022), P(EE2.3.30.0061)
n3:cisloPeriodika
1
n3:dodaniDat
n9:2015
n3:domaciTvurceVysledku
n12:9990801 n12:9640347 n12:6628249 Dev, Kapil Diaz Garcia, Daniel Shaikh Qureshi, Wasay Mohiuddin
n3:druhVysledku
n20:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
44803
n3:idVysledku
RIV/00216208:11150/14:10189919
n3:jazykVysledku
n8:eng
n3:klicovaSlova
BMP; Notch; Shh; Wnt; signaling; stem cell; morphogenesis; hair follicle
n3:klicoveSlovo
n13:BMP n13:Shh n13:morphogenesis n13:Wnt n13:stem%20cell n13:signaling n13:Notch n13:hair%20follicle
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[AEB144095E2D]
n3:nazevZdroje
International Journal of Molecular Sciences
n3:obor
n14:EB
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n15:EE2.3.30.0022 n15:EE2.3.30.0061
n3:rokUplatneniVysledku
n9:2014
n3:svazekPeriodika
15
n3:tvurceVysledku
Filip, Stanislav Mokrý, Jaroslav Pisal, Rishikaysh Shaikh Qureshi, Wasay Mohiuddin Dev, Kapil Diaz Garcia, Daniel
n3:wos
000335776100098
s:issn
1422-0067
s:numberOfPages
24
n11:doi
10.3390/ijms15011647
n7:organizacniJednotka
11150