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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F13%3A10193965%21RIV14-MSM-11150___
rdf:type
n11:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1016/j.neuroscience.2012.04.061
dcterms:description
Because dendritic spines are the sites of excitatory synapses, pathological changes in spine morphology should be considered as part of pathological changes in neuronal circuitry in the forms of synaptic connections and connectivity strength. In the past, spine pathology has usually been measured by changes in their number or shape. A more complete understanding of spine pathology requires visualization at the nanometer level to analyze how the changes in number and size affect their presynaptic partners and associated astrocytic processes, as well as organelles and other intracellular structures. Currently, serial section electron microscopy (ssEM) offers the best approach to address this issue because of its ability to image the volume of brain tissue at the nanometer resolution. Renewed interest in ssEM has led to recent technological advances in imaging techniques and improvements in computational tools indispensable for three-dimensional analyses of brain tissue volumes. Here we consider the small but growing literature that has used ssEM analysis to unravel ultrastructural changes in neuropil including dendritic spines. These findings have implications in altered synaptic connectivity and cell biological processes involved in neuropathology, and serve as anatomical substrates for understanding changes in network activity that may underlie clinical symptoms. This article is part of a Special Issue entitled: Dendritic Spine Plasticity in Brain Disorders. (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved. Because dendritic spines are the sites of excitatory synapses, pathological changes in spine morphology should be considered as part of pathological changes in neuronal circuitry in the forms of synaptic connections and connectivity strength. In the past, spine pathology has usually been measured by changes in their number or shape. A more complete understanding of spine pathology requires visualization at the nanometer level to analyze how the changes in number and size affect their presynaptic partners and associated astrocytic processes, as well as organelles and other intracellular structures. Currently, serial section electron microscopy (ssEM) offers the best approach to address this issue because of its ability to image the volume of brain tissue at the nanometer resolution. Renewed interest in ssEM has led to recent technological advances in imaging techniques and improvements in computational tools indispensable for three-dimensional analyses of brain tissue volumes. Here we consider the small but growing literature that has used ssEM analysis to unravel ultrastructural changes in neuropil including dendritic spines. These findings have implications in altered synaptic connectivity and cell biological processes involved in neuropathology, and serve as anatomical substrates for understanding changes in network activity that may underlie clinical symptoms. This article is part of a Special Issue entitled: Dendritic Spine Plasticity in Brain Disorders. (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
dcterms:title
Beyond counts and shapes: studying pathology of dendritic spines in the context of the surrounding neuropil through serial section electron microscopy Beyond counts and shapes: studying pathology of dendritic spines in the context of the surrounding neuropil through serial section electron microscopy
skos:prefLabel
Beyond counts and shapes: studying pathology of dendritic spines in the context of the surrounding neuropil through serial section electron microscopy Beyond counts and shapes: studying pathology of dendritic spines in the context of the surrounding neuropil through serial section electron microscopy
skos:notation
RIV/00216208:11150/13:10193965!RIV14-MSM-11150___
n11:predkladatel
n13:orjk%3A11150
n3:aktivita
n19:N
n3:aktivity
N
n3:cisloPeriodika
SI
n3:dodaniDat
n14:2014
n3:domaciTvurceVysledku
n12:3246663
n3:druhVysledku
n9:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
63158
n3:idVysledku
RIV/00216208:11150/13:10193965
n3:jazykVysledku
n6:eng
n3:klicovaSlova
ultrastructure; scanning transmission electron microscopy; pathology; neuropil; connectome; 3D reconstruction
n3:klicoveSlovo
n4:ultrastructure n4:pathology n4:3D%20reconstruction n4:scanning%20transmission%20electron%20microscopy n4:neuropil n4:connectome
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[7BBEFA819305]
n3:nazevZdroje
Neuroscience
n3:obor
n17:FP
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n14:2013
n3:svazekPeriodika
251
n3:tvurceVysledku
Harris, K. M. Špaček, Josef Kuwajima, M.
n3:wos
000325383300007
s:issn
0306-4522
s:numberOfPages
15
n15:doi
10.1016/j.neuroscience.2012.04.061
n5:organizacniJednotka
11150