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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F13%3A10190982%21RIV14-MSM-11150___
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://biomed.papers.upol.cz/pdfs/bio/2013/04/04.pdf
dcterms:description
Aims. Ovarian cancer is the most lethal gynecological malignancy, with typically late diagnosis. Altered DNA methylation of tumor suppressor gene promoters probably plays a relevant role in ovarian carcinogenesis and frequently occurs as an early event in the development of different types of cancer including ovarian carcinoma. GATA4 methylation has been reported in a variety of human cancers. The aim of this study was to investigate promoter methylation of the GATA4 gene in ovarian cancer by comparison with that in normal ovarian tissue. Methods. To search for promoter methylation of the GATA4 gene we used MSP (methylation-specific PCR) to compare the methylation status in 67 tissue samples of ovarian cancer with that in 40 control samples. Results. In our study, methylation-specific PCR revealed GATA4 promoter methylation in 21 of 67 specimens with ovarian cancer (31.3%), and in none of the control ovarian tissue samples. Conclusion. These results confirm that methylation in the GATA4 promoter region could play an important role in ovarian carcinogenesis, and show new loci which are highly methylated only in ovarian cancer samples and which are associated predominantly with the endometrioid type of ovarian carcinoma. Aims. Ovarian cancer is the most lethal gynecological malignancy, with typically late diagnosis. Altered DNA methylation of tumor suppressor gene promoters probably plays a relevant role in ovarian carcinogenesis and frequently occurs as an early event in the development of different types of cancer including ovarian carcinoma. GATA4 methylation has been reported in a variety of human cancers. The aim of this study was to investigate promoter methylation of the GATA4 gene in ovarian cancer by comparison with that in normal ovarian tissue. Methods. To search for promoter methylation of the GATA4 gene we used MSP (methylation-specific PCR) to compare the methylation status in 67 tissue samples of ovarian cancer with that in 40 control samples. Results. In our study, methylation-specific PCR revealed GATA4 promoter methylation in 21 of 67 specimens with ovarian cancer (31.3%), and in none of the control ovarian tissue samples. Conclusion. These results confirm that methylation in the GATA4 promoter region could play an important role in ovarian carcinogenesis, and show new loci which are highly methylated only in ovarian cancer samples and which are associated predominantly with the endometrioid type of ovarian carcinoma.
dcterms:title
Importance of promoter methylation of GATA4 gene in epithelial ovarian cancer Importance of promoter methylation of GATA4 gene in epithelial ovarian cancer
skos:prefLabel
Importance of promoter methylation of GATA4 gene in epithelial ovarian cancer Importance of promoter methylation of GATA4 gene in epithelial ovarian cancer
skos:notation
RIV/00216208:11150/13:10190982!RIV14-MSM-11150___
n17:predkladatel
n18:orjk%3A11150
n3:aktivita
n4:I n4:S n4:P
n3:aktivity
I, P(LM2010004), S
n3:cisloPeriodika
4
n3:dodaniDat
n14:2014
n3:domaciTvurceVysledku
n7:6953891 n7:2010887 n7:8934460 n7:1117149 n7:3299643
n3:druhVysledku
n8:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
79245
n3:idVysledku
RIV/00216208:11150/13:10190982
n3:jazykVysledku
n13:eng
n3:klicovaSlova
epigenetics; ovarian cancer; GATA4; methylation
n3:klicoveSlovo
n5:ovarian%20cancer n5:epigenetics n5:methylation n5:GATA4
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[5F77D10709B8]
n3:nazevZdroje
Biomedical Papers
n3:obor
n9:CE
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n12:LM2010004
n3:rokUplatneniVysledku
n14:2013
n3:svazekPeriodika
157
n3:tvurceVysledku
Laco, Jan Chmelařová, Marcela Palička, Vladimír Dvořáková, Eva Špaček, Jiří
n3:wos
000329091500005
s:issn
1213-8118
s:numberOfPages
4
n6:doi
10.5507/bp.2013.079
n10:organizacniJednotka
11150