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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F13%3A10190725%21RIV14-MSM-11150___
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
http://www.biomed.cas.cz/physiolres/pdf/62/62_S135.pdf
dcterms:description
Chronic continuous light exposure leads to melatonin deficiency along with complex neurohumoral activation resulting in hypertension. The aim of this study was to show, whether continuous light induces fibrotic rebuilding of the aorta and whether the treatment with melatonin or captopril can prevent these potential alterations. In a six-week experiment, Wistar rats were divided into 4 groups: controls, rats exposed to continuous light (LC), LC + captopril (100 mg/kg/24 h) and LC + melatonin (10 mg/kg/24 h). We conclude that in continuous light-induced hypertension, administration of melatonin, along with SBP reduction, decreases collagen I and III concentration in the aorta. It is suggested that antifibrotic effect of melatonin may reduce the stiffness of the aorta and small arteries and beneficially influence the peripheral vascular resistance. Chronic continuous light exposure leads to melatonin deficiency along with complex neurohumoral activation resulting in hypertension. The aim of this study was to show, whether continuous light induces fibrotic rebuilding of the aorta and whether the treatment with melatonin or captopril can prevent these potential alterations. In a six-week experiment, Wistar rats were divided into 4 groups: controls, rats exposed to continuous light (LC), LC + captopril (100 mg/kg/24 h) and LC + melatonin (10 mg/kg/24 h). We conclude that in continuous light-induced hypertension, administration of melatonin, along with SBP reduction, decreases collagen I and III concentration in the aorta. It is suggested that antifibrotic effect of melatonin may reduce the stiffness of the aorta and small arteries and beneficially influence the peripheral vascular resistance.
dcterms:title
Effect of Captopril and Melatonin on Fibrotic Rebuilding of the Aorta in 24 Hour Light-Induced Hypertension Effect of Captopril and Melatonin on Fibrotic Rebuilding of the Aorta in 24 Hour Light-Induced Hypertension
skos:prefLabel
Effect of Captopril and Melatonin on Fibrotic Rebuilding of the Aorta in 24 Hour Light-Induced Hypertension Effect of Captopril and Melatonin on Fibrotic Rebuilding of the Aorta in 24 Hour Light-Induced Hypertension
skos:notation
RIV/00216208:11150/13:10190725!RIV14-MSM-11150___
n10:predkladatel
n11:orjk%3A11150
n5:aktivita
n19:I
n5:aktivity
I
n5:cisloPeriodika
Suppl. 1
n5:dodaniDat
n12:2014
n5:domaciTvurceVysledku
n8:7344856
n5:druhVysledku
n18:J
n5:duvernostUdaju
n15:S
n5:entitaPredkladatele
n16:predkladatel
n5:idSjednocenehoVysledku
71394
n5:idVysledku
RIV/00216208:11150/13:10190725
n5:jazykVysledku
n9:eng
n5:klicovaSlova
Collagen I and III; Captopril; Melatonin; Fibrosis; Hypertension; Continuous light
n5:klicoveSlovo
n6:Collagen%20I%20and%20III n6:Melatonin n6:Hypertension n6:Continuous%20light n6:Captopril n6:Fibrosis
n5:kodStatuVydavatele
CZ - Česká republika
n5:kontrolniKodProRIV
[9434CA109482]
n5:nazevZdroje
Physiological Research
n5:obor
n17:ED
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
7
n5:rokUplatneniVysledku
n12:2013
n5:svazekPeriodika
62
n5:tvurceVysledku
Šimko, Fedor Repová-Bednarová, Kristina Aziriová, Silvia Adamcová, Michaela Paulis, Ludovít Krajčírovičová, Kristina Hrenák, Jaroslav
n5:wos
000328901900015
s:issn
0862-8408
s:numberOfPages
7
n4:organizacniJednotka
11150