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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F13%3A10174035%21RIV14-MSM-11150___
rdf:type
n12:Vysledek skos:Concept
rdfs:seeAlso
http://fb.cuni.cz/file/5700/FB2013A0027.pdf
dcterms:description
Head and neck cancer is one of the most common cancers in Europe. Many current anti-cancer treatments, including ionizing radiation, induce apoptosis via DNA damage. Unfortunately, such treatments are non-selective to cancer cells and produce similar toxicity in normal cells, including adult stem cells. One of the fundamental properties of an adult stem cell is that it does not have any tissue-specific structures that allow it to perform specialized functions. However, under certain stimuli, unspecialized adult stem cells can give rise to specialized cells to generate replacements for cells that are lost during one's life or due to injury or disease. Nevertheless, specialization of stem cells must be controlled by specific milieu and also initiated at the proper time, making the entire process beneficial for tissue recovery and maintaining it for a long time. In this paper we assess whether irradiated dental pulp stem cells have maintained open their options to mature into specialized cells, or whether they have lost their unspecialized (immature) state following irradiation. Our findings showed radiation-induced premature differentiation of dental pulp stem cells towards odonto-/osteoblast lineages in vitro. Matrix calcification was visualized from Day 6 or Day 9 following irradiation of cells expressing low or high levels of CD 146, respectively. Head and neck cancer is one of the most common cancers in Europe. Many current anti-cancer treatments, including ionizing radiation, induce apoptosis via DNA damage. Unfortunately, such treatments are non-selective to cancer cells and produce similar toxicity in normal cells, including adult stem cells. One of the fundamental properties of an adult stem cell is that it does not have any tissue-specific structures that allow it to perform specialized functions. However, under certain stimuli, unspecialized adult stem cells can give rise to specialized cells to generate replacements for cells that are lost during one's life or due to injury or disease. Nevertheless, specialization of stem cells must be controlled by specific milieu and also initiated at the proper time, making the entire process beneficial for tissue recovery and maintaining it for a long time. In this paper we assess whether irradiated dental pulp stem cells have maintained open their options to mature into specialized cells, or whether they have lost their unspecialized (immature) state following irradiation. Our findings showed radiation-induced premature differentiation of dental pulp stem cells towards odonto-/osteoblast lineages in vitro. Matrix calcification was visualized from Day 6 or Day 9 following irradiation of cells expressing low or high levels of CD 146, respectively.
dcterms:title
Ionizing Radiation Induces Senescence and Differentiation of Human Dental Pulp Stem Cells Ionizing Radiation Induces Senescence and Differentiation of Human Dental Pulp Stem Cells
skos:prefLabel
Ionizing Radiation Induces Senescence and Differentiation of Human Dental Pulp Stem Cells Ionizing Radiation Induces Senescence and Differentiation of Human Dental Pulp Stem Cells
skos:notation
RIV/00216208:11150/13:10174035!RIV14-MSM-11150___
n12:predkladatel
n13:orjk%3A11150
n3:aktivita
n18:P n18:I n18:V
n3:aktivity
I, P(EE2.3.30.0022), P(EE2.3.30.0058), V
n3:cisloPeriodika
5
n3:dodaniDat
n15:2014
n3:domaciTvurceVysledku
n6:9433597 n6:6452965 n6:8982007 n6:6518672 n6:5439426 n6:1848445 n6:6628249 n6:5403065
n3:druhVysledku
n17:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
81203
n3:idVysledku
RIV/00216208:11150/13:10174035
n3:jazykVysledku
n16:eng
n3:klicovaSlova
osteogenesis; dentinogenesis; radiation-induced premature differentiation; ionizing radiation; Dental pulp stem cells
n3:klicoveSlovo
n5:ionizing%20radiation n5:dentinogenesis n5:Dental%20pulp%20stem%20cells n5:radiation-induced%20premature%20differentiation n5:osteogenesis
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[3AD2B994E9C9]
n3:nazevZdroje
Folia Biologica
n3:obor
n14:CE
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
9
n3:projekt
n7:EE2.3.30.0022 n7:EE2.3.30.0058
n3:rokUplatneniVysledku
n15:2013
n3:svazekPeriodika
59
n3:tvurceVysledku
Vávrová, Jiřina Muthná, Darina Seifrtová, Martina Ćmielová, Jana Mokrý, Jaroslav Havelek, Radim Suchánek, Jakub Soukup, Tomáš Řezáčová, Martina
n3:wos
000327577300003
s:issn
0015-5500
s:numberOfPages
10
n11:organizacniJednotka
11150