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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F13%3A10173742%21RIV14-MSM-11150___
rdf:type
skos:Concept n18:Vysledek
rdfs:seeAlso
http://actavet.vfu.cz/pdf/201382030289.pdf
dcterms:description
The aim of the study was to develop a diet which causes stable hyperglycaemia and development of diabetes in female Zucker diabetic fatty (ZDF) rats. We also examined whether worsened wound healing is caused only by hyperglycaemia or whether it is caused by more factors. Four types of special diets with a different content of fat were fed to eight groups of 3-7 (fa/fa or fa/+) rats. The following diets were used: H1 (24.6% fat), H2 (33.2%), C13004 (25.6%), and St1 (3.4%). We detected significant diet-dependent changes of weight and concentration of glucose in animals with leptin mutation (fa/fa). All examined indicators were significantly (P < 0.001) higher in (fa/fa) animals compared to the fa/+ ones no matter what diet they ate. All diets with high-fat content caused increased glycaemia, but only the diet with 24.6% fat caused a significant (P < 0.01) increase of glycaemia. Our results have proved that this diet is the most suitable to invoke and keep hyperglycaemia. The diet with 25.6% fat is suitable to invoke stable slightly increased glycaemia (10 mmol/l) and hyperinsulinaemia. On the other hand, the diet with 33.2% fat is unsuitable. We did not observe a significant influence of diet on wound healing. We developed a new diet more suitable for induction of stable hyperglycaemia in female ZDF rats than commercially available mixtures. Our study is the first to present recommendations for adjusting a high-fat diet to produce stable hyperglycaemia and hyperinsulinaemia in the rat model. The aim of the study was to develop a diet which causes stable hyperglycaemia and development of diabetes in female Zucker diabetic fatty (ZDF) rats. We also examined whether worsened wound healing is caused only by hyperglycaemia or whether it is caused by more factors. Four types of special diets with a different content of fat were fed to eight groups of 3-7 (fa/fa or fa/+) rats. The following diets were used: H1 (24.6% fat), H2 (33.2%), C13004 (25.6%), and St1 (3.4%). We detected significant diet-dependent changes of weight and concentration of glucose in animals with leptin mutation (fa/fa). All examined indicators were significantly (P < 0.001) higher in (fa/fa) animals compared to the fa/+ ones no matter what diet they ate. All diets with high-fat content caused increased glycaemia, but only the diet with 24.6% fat caused a significant (P < 0.01) increase of glycaemia. Our results have proved that this diet is the most suitable to invoke and keep hyperglycaemia. The diet with 25.6% fat is suitable to invoke stable slightly increased glycaemia (10 mmol/l) and hyperinsulinaemia. On the other hand, the diet with 33.2% fat is unsuitable. We did not observe a significant influence of diet on wound healing. We developed a new diet more suitable for induction of stable hyperglycaemia in female ZDF rats than commercially available mixtures. Our study is the first to present recommendations for adjusting a high-fat diet to produce stable hyperglycaemia and hyperinsulinaemia in the rat model.
dcterms:title
Effect of diets with different fat contents on the development of diabetes in female Zucker diabetic fatty rat with leptin mutation Effect of diets with different fat contents on the development of diabetes in female Zucker diabetic fatty rat with leptin mutation
skos:prefLabel
Effect of diets with different fat contents on the development of diabetes in female Zucker diabetic fatty rat with leptin mutation Effect of diets with different fat contents on the development of diabetes in female Zucker diabetic fatty rat with leptin mutation
skos:notation
RIV/00216208:11150/13:10173742!RIV14-MSM-11150___
n18:predkladatel
n19:orjk%3A11150
n3:aktivita
n10:I n10:S
n3:aktivity
I, S
n3:cisloPeriodika
3
n3:dodaniDat
n8:2014
n3:domaciTvurceVysledku
n4:7723830 n4:7044437
n3:druhVysledku
n11:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
71461
n3:idVysledku
RIV/00216208:11150/13:10173742
n3:jazykVysledku
n15:eng
n3:klicovaSlova
wound healing; MMP-3; leptin mutation; insulinaemia; Glycaemia
n3:klicoveSlovo
n7:wound%20healing n7:leptin%20mutation n7:insulinaemia n7:Glycaemia n7:MMP-3
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[93432942CB5A]
n3:nazevZdroje
Acta Veterinaria Brno
n3:obor
n14:CE
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n8:2013
n3:svazekPeriodika
82
n3:tvurceVysledku
Köhlerová, Renata Jiroutová, Alena Slavkovský, Rastislav Sznapková, Martina
n3:wos
000327909400011
s:issn
0001-7213
s:numberOfPages
8
n17:doi
10.2754/avb201382030289
n16:organizacniJednotka
11150