This HTML5 document contains 52 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n17http://localhost/temp/predkladatel/
n9http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n15http://linked.opendata.cz/resource/domain/vavai/subjekt/
n6http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
rdfshttp://www.w3.org/2000/01/rdf-schema#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n12http://bibframe.org/vocab/
n11http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216208%3A11150%2F13%3A10139484%21RIV14-MSM-11150___/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n4http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n20http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n5http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n19http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n13http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n7http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F13%3A10139484%21RIV14-MSM-11150___
rdf:type
n6:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1016/j.aller.2012.02.006
dcterms:description
Background: CD163 is the monocyte/macrophage receptor for haptoglobin-haemoglobin complexes. The aim of this study was to assess the kinetics in the expression of CD163 on monocytes and the concentration of soluble sCD163 in serum of psoriatic patients in order to examine the effect of Goeckerman therapy. Methods: sCD163 was measured in 71 patients before and after therapy, and in 57 healthy donors. A subgroup of 40 patients and 25 controls was used to assess the expression of membrane CD163. sCD163 was evaluated by ELISA. Flow cytometry method was used to determine the expression of membrane CD163 on monocytes, expressed as mean fluorescence index (MFI). Results: Before therapy, the serum level of sCD163 was significantly higher in our patients than in controls (P=0.0154). However, we observed a profound decrease in sCD163 in our patients after therapy (P=0.0037). Similar to sCD163, pre-treatment expression of CD163 on monocytes was significantly more enhanced in patients than that in controls (P=0.0078). There was a trend towards down-regulation of the expression after therapy, nonetheless, the change was not statistically significant compared to the values before therapy (P=0.8666). This was also confirmed by comparison with controls which displayed lower expression of CD163 than patients after therapy (P=0.0019). The disease activity, expressed as PASI score, was significantly decreased in our patients by GT (P=0.0001). Conclusions: While sCD163 level in psoriatic patients was diminished after GT therapy, CD163 expression on monocytes was altered only to a minor extent. Background: CD163 is the monocyte/macrophage receptor for haptoglobin-haemoglobin complexes. The aim of this study was to assess the kinetics in the expression of CD163 on monocytes and the concentration of soluble sCD163 in serum of psoriatic patients in order to examine the effect of Goeckerman therapy. Methods: sCD163 was measured in 71 patients before and after therapy, and in 57 healthy donors. A subgroup of 40 patients and 25 controls was used to assess the expression of membrane CD163. sCD163 was evaluated by ELISA. Flow cytometry method was used to determine the expression of membrane CD163 on monocytes, expressed as mean fluorescence index (MFI). Results: Before therapy, the serum level of sCD163 was significantly higher in our patients than in controls (P=0.0154). However, we observed a profound decrease in sCD163 in our patients after therapy (P=0.0037). Similar to sCD163, pre-treatment expression of CD163 on monocytes was significantly more enhanced in patients than that in controls (P=0.0078). There was a trend towards down-regulation of the expression after therapy, nonetheless, the change was not statistically significant compared to the values before therapy (P=0.8666). This was also confirmed by comparison with controls which displayed lower expression of CD163 than patients after therapy (P=0.0019). The disease activity, expressed as PASI score, was significantly decreased in our patients by GT (P=0.0001). Conclusions: While sCD163 level in psoriatic patients was diminished after GT therapy, CD163 expression on monocytes was altered only to a minor extent.
dcterms:title
Expression of soluble sCD163 in serum of psoriatic patients is modulated by Goeckerman therapy Expression of soluble sCD163 in serum of psoriatic patients is modulated by Goeckerman therapy
skos:prefLabel
Expression of soluble sCD163 in serum of psoriatic patients is modulated by Goeckerman therapy Expression of soluble sCD163 in serum of psoriatic patients is modulated by Goeckerman therapy
skos:notation
RIV/00216208:11150/13:10139484!RIV14-MSM-11150___
n6:predkladatel
n15:orjk%3A11150
n3:aktivita
n20:I n20:S
n3:aktivity
I, S
n3:cisloPeriodika
3
n3:dodaniDat
n7:2014
n3:domaciTvurceVysledku
n9:8222525 n9:4845390 n9:5074851 n9:8520372 n9:7584881
n3:druhVysledku
n19:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
74356
n3:idVysledku
RIV/00216208:11150/13:10139484
n3:jazykVysledku
n5:eng
n3:klicovaSlova
Scavenger receptor; Psoriasis; Monocytes; Goeckerman therapy; CD163
n3:klicoveSlovo
n4:Scavenger%20receptor n4:Goeckerman%20therapy n4:Psoriasis n4:CD163 n4:Monocytes
n3:kodStatuVydavatele
ES - Španělské království
n3:kontrolniKodProRIV
[F3DBA23E335E]
n3:nazevZdroje
Allergologia et Immunopathologia
n3:obor
n13:FN
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n7:2013
n3:svazekPeriodika
41
n3:tvurceVysledku
Fiala, Zdeněk Kondělková, Kateřina Andrýs, Ctirad Krejsek, Jan Hamáková, Květoslava Borská, Lenka
n3:wos
000320343200004
s:issn
0301-0546
s:numberOfPages
5
n12:doi
10.1016/j.aller.2012.02.006
n17:organizacniJednotka
11150