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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F13%3A10139017%21RIV14-MSM-11150___
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1155/2013/478349
dcterms:description
Whipple's disease is a chronic infectious systemic disease caused by the bacterium Tropheryma whipplei. Nondeforming arthritis is frequently an initial complaint. Gastrointestinal and general symptoms include marked diarrhoea (with serious malabsorption), abdominal pain, prominent weight loss, and low-grade fever. Possible neurologic symptoms (up to 20%) might be associated with worse prognosis. Diagnosis is based on the clinical picture and small intestinal histology revealing foamy macrophages containing periodic-acid-Schiff- (PAS-) positive material. Long-term (up to one year) antibiotic therapy provides a favourable outcome in the vast majority of cases. This paper provides review of the literature and an analysis of our 5 patients recorded within a 20-year period at a tertiary gastroenterology centre. Patients were treated using i.v. penicillin G or amoxicillin-clavulanic acid + i.v. gentamicin for two weeks, followed by p.o. doxycycline (100 mg per day) plus p.o. salazopyrine (3 g per day) for 1 year. Full remission was achieved in all our patients. Whipple's disease is a chronic infectious systemic disease caused by the bacterium Tropheryma whipplei. Nondeforming arthritis is frequently an initial complaint. Gastrointestinal and general symptoms include marked diarrhoea (with serious malabsorption), abdominal pain, prominent weight loss, and low-grade fever. Possible neurologic symptoms (up to 20%) might be associated with worse prognosis. Diagnosis is based on the clinical picture and small intestinal histology revealing foamy macrophages containing periodic-acid-Schiff- (PAS-) positive material. Long-term (up to one year) antibiotic therapy provides a favourable outcome in the vast majority of cases. This paper provides review of the literature and an analysis of our 5 patients recorded within a 20-year period at a tertiary gastroenterology centre. Patients were treated using i.v. penicillin G or amoxicillin-clavulanic acid + i.v. gentamicin for two weeks, followed by p.o. doxycycline (100 mg per day) plus p.o. salazopyrine (3 g per day) for 1 year. Full remission was achieved in all our patients.
dcterms:title
Whipple's Disease: Our Own Experience and Review of the Literature Whipple's Disease: Our Own Experience and Review of the Literature
skos:prefLabel
Whipple's Disease: Our Own Experience and Review of the Literature Whipple's Disease: Our Own Experience and Review of the Literature
skos:notation
RIV/00216208:11150/13:10139017!RIV14-MSM-11150___
n12:predkladatel
n13:orjk%3A11150
n3:aktivita
n15:I
n3:aktivity
I
n3:cisloPeriodika
2013
n3:dodaniDat
n9:2014
n3:domaciTvurceVysledku
n8:1363093 n8:2058030 n8:3608670 n8:6725856 n8:4520602 n8:2565986
n3:druhVysledku
n17:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
117326
n3:idVysledku
RIV/00216208:11150/13:10139017
n3:jazykVysledku
n6:eng
n3:klicovaSlova
bacterium; whippelii; endoscopy; prevalence; ceftriaxone; patient; infection; involvement; antibiotic susceptibility; tropheryma-whipplei
n3:klicoveSlovo
n4:infection n4:whippelii n4:endoscopy n4:patient n4:ceftriaxone n4:bacterium n4:antibiotic%20susceptibility n4:prevalence n4:involvement n4:tropheryma-whipplei
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[C6795F65DB47]
n3:nazevZdroje
Gastroenterology Research and Practice
n3:obor
n18:FE
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n9:2013
n3:svazekPeriodika
Neuveden
n3:tvurceVysledku
Rejchrt, Stanislav Tachecí, Ilja Tomš, Jan Bártová, Jolana Bureš, Jan Kopáčová, Marcela Douda, Tomáš
n3:wos
000321353600001
s:issn
1687-6121
s:numberOfPages
10
n7:doi
10.1155/2013/478349
n16:organizacniJednotka
11150