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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F13%3A10133853%21RIV14-MZ0-11150___
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.atherosclerosissup.2012.10.019
dcterms:description
Objective: Mean platelet volume is arousing increasing interest as a new independent cardiovascular risk factor. Large platelets are likely to be more reactive. If mean platelet volume would drop after LDL-lowering therapy, decreased MPV could be one of the markers of successful therapy. Therefore, we investigated mean platelet volume after extracorporeal LDL-cholesterol elimination. Methods: Mean platelet volume was investigated in patients with severe familial hypercholesterolemia long-term treated (3-12 years) by LDL-apheresis (immunoapheresis) or cascade filtration. Plasma was obtained by centrifugation. Adsorbers Lipopak 400 were used for immunoapheresis and filters Evaflux 4A were used for cascade filtration. 95 pair samples were measured (before and after the procedures) in a group of 12 patients - each patient 8 times in 4 years. Results: Mean platelet volume before the procedures was 10.891 fl, CI 10.25-11.53. Mean platelet volume after the procedures decreased - 10.478 fl, CI 09.84-11.11. The difference is statistically significant (p = 0.036). Mean platelet volume did not correlate with age, sex, platelet count, duration of therapy. At the same time, we used rheohemapheresis in the therapy of 40 patients with age-related macular degeneration. But mean platelet volume was not changed. Conclusion: Mean platelet volume is easily available and is often disregarded, and sometimes may suggest the need for a careful assessment in patients with familial hypercholesterolemia. Mean platelet volume could be one of the markers of therapeutic efficacy in patients with familial hypercholesterolemia treated by extracorporeal LDL-cholesterol elimination that is simple and inexpensive. Objective: Mean platelet volume is arousing increasing interest as a new independent cardiovascular risk factor. Large platelets are likely to be more reactive. If mean platelet volume would drop after LDL-lowering therapy, decreased MPV could be one of the markers of successful therapy. Therefore, we investigated mean platelet volume after extracorporeal LDL-cholesterol elimination. Methods: Mean platelet volume was investigated in patients with severe familial hypercholesterolemia long-term treated (3-12 years) by LDL-apheresis (immunoapheresis) or cascade filtration. Plasma was obtained by centrifugation. Adsorbers Lipopak 400 were used for immunoapheresis and filters Evaflux 4A were used for cascade filtration. 95 pair samples were measured (before and after the procedures) in a group of 12 patients - each patient 8 times in 4 years. Results: Mean platelet volume before the procedures was 10.891 fl, CI 10.25-11.53. Mean platelet volume after the procedures decreased - 10.478 fl, CI 09.84-11.11. The difference is statistically significant (p = 0.036). Mean platelet volume did not correlate with age, sex, platelet count, duration of therapy. At the same time, we used rheohemapheresis in the therapy of 40 patients with age-related macular degeneration. But mean platelet volume was not changed. Conclusion: Mean platelet volume is easily available and is often disregarded, and sometimes may suggest the need for a careful assessment in patients with familial hypercholesterolemia. Mean platelet volume could be one of the markers of therapeutic efficacy in patients with familial hypercholesterolemia treated by extracorporeal LDL-cholesterol elimination that is simple and inexpensive.
dcterms:title
The decrease of mean platelet volume after extracorporeal LDL-cholesterol elimination The decrease of mean platelet volume after extracorporeal LDL-cholesterol elimination
skos:prefLabel
The decrease of mean platelet volume after extracorporeal LDL-cholesterol elimination The decrease of mean platelet volume after extracorporeal LDL-cholesterol elimination
skos:notation
RIV/00216208:11150/13:10133853!RIV14-MZ0-11150___
n15:predkladatel
n20:orjk%3A11150
n3:aktivita
n12:I n12:P
n3:aktivity
I, P(NT12287)
n3:cisloPeriodika
1
n3:dodaniDat
n19:2014
n3:domaciTvurceVysledku
n6:5598877 n6:9990801 n6:5800382 n6:9763465 n6:6295452 n6:5836433 n6:5428513
n3:druhVysledku
n17:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
68115
n3:idVysledku
RIV/00216208:11150/13:10133853
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Rheohemapheresis; Therapeutic hemapheresis; Extracorporeal elimination; LDL-apheresis; Familial hyperlipoproteinemia; Mean platelet volume
n3:klicoveSlovo
n4:Familial%20hyperlipoproteinemia n4:Rheohemapheresis n4:Extracorporeal%20elimination n4:Mean%20platelet%20volume n4:Therapeutic%20hemapheresis n4:LDL-apheresis
n3:kodStatuVydavatele
IE - Irsko
n3:kontrolniKodProRIV
[D1AF18206DAD]
n3:nazevZdroje
Atherosclerosis Supplements
n3:obor
n21:FD
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
8
n3:projekt
n8:NT12287
n3:rokUplatneniVysledku
n19:2013
n3:svazekPeriodika
14
n3:tvurceVysledku
Foralová, I. Malý, Jaroslav Lánská, Miriam Kubišová, Michaela Bláha, Vladimír Filip, Stanislav Košťál, Milan Bláha, Milan
n3:wos
000314885000014
s:issn
1567-5688
s:numberOfPages
5
n16:doi
10.1016/j.atherosclerosissup.2012.10.019
n11:organizacniJednotka
11150