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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F13%3A10126505%21RIV14-MSM-11150___
rdf:type
n15:Vysledek skos:Concept
rdfs:seeAlso
http://link.springer.com/article/10.1007%2Fs12094-012-0894-z
dcterms:description
Ovarian cancer is a leading cause of death from gynecologic tumors, however epigenetic events underlying this transformation are poorly understood. Promoter methylation status of tumor suppressor genes may be associated with transcriptional silencing and tumor progression. It has been shown that methylation located in the promoter region of p53 is associated with low expression of this gene. The aim of this study was to investigate promoter methylation of p53 gene in ovarian cancer by comparison with normal ovarian tissue. We used methylation-specific PCR to compare the methylation status of p53 promoter of 66 tissue samples of ovarian cancer with 37 control samples. In our study methylation specific PCR revealed p53 promoter methylation in 34 of 66 (51.5 %) of specimens with ovarian cancer. These results indicate that methylation in p53 promoter region may play an important role in carcinogenesis of ovarian cancer. Ovarian cancer is a leading cause of death from gynecologic tumors, however epigenetic events underlying this transformation are poorly understood. Promoter methylation status of tumor suppressor genes may be associated with transcriptional silencing and tumor progression. It has been shown that methylation located in the promoter region of p53 is associated with low expression of this gene. The aim of this study was to investigate promoter methylation of p53 gene in ovarian cancer by comparison with normal ovarian tissue. We used methylation-specific PCR to compare the methylation status of p53 promoter of 66 tissue samples of ovarian cancer with 37 control samples. In our study methylation specific PCR revealed p53 promoter methylation in 34 of 66 (51.5 %) of specimens with ovarian cancer. These results indicate that methylation in p53 promoter region may play an important role in carcinogenesis of ovarian cancer.
dcterms:title
Methylation in the p53 promoter in epithelial ovarian cancer Methylation in the p53 promoter in epithelial ovarian cancer
skos:prefLabel
Methylation in the p53 promoter in epithelial ovarian cancer Methylation in the p53 promoter in epithelial ovarian cancer
skos:notation
RIV/00216208:11150/13:10126505!RIV14-MSM-11150___
n15:predkladatel
n16:orjk%3A11150
n3:aktivita
n18:I n18:S
n3:aktivity
I, S
n3:cisloPeriodika
2
n3:dodaniDat
n5:2014
n3:domaciTvurceVysledku
n10:3299643 n10:6953891 n10:2010887 n10:8934460 n10:1117149
n3:druhVysledku
n17:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
87657
n3:idVysledku
RIV/00216208:11150/13:10126505
n3:jazykVysledku
n13:eng
n3:klicovaSlova
ovarian cancer; promoter methylation; p53
n3:klicoveSlovo
n9:p53 n9:ovarian%20cancer n9:promoter%20methylation
n3:kodStatuVydavatele
ES - Španělské království
n3:kontrolniKodProRIV
[D17E516AC46E]
n3:nazevZdroje
Clinical and Translational Oncology
n3:obor
n12:EB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n5:2013
n3:svazekPeriodika
15
n3:tvurceVysledku
Palička, Vladimír Špaček, Jiří Beránek, Martin Křepinská, Eva Chmelařová, Marcela Laco, Jan
n3:wos
000314280500011
s:issn
1699-048X
s:numberOfPages
4
n19:doi
10.1007/s12094-012-0894-z
n20:organizacniJednotka
11150