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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F12%3A10125479%21RIV13-MSM-11150___
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1002/jca.21243/pdf
dcterms:description
Objective: The aim of this pilot study was to evaluate the efficacy of visual evoked potentials (VEPs) in the monitoring of visual function during a high-dose intravenous steroid pulse therapy and apheresis treatment of severe Graves' ophthalmopathy (GO). Patients and Research Design: Nine patients with severe and active GO were treated with high-dose Methylprednisolone (1 g/day 3 times within 1 week, then 0.5 g/day 7 times for 2 weeks) combined with plasma filtration (twice a week in weeks 1, 2, 4, 7, and 10). Pattern-reversal and motion-onset VEPs were examined three times, pre-treatment, after steroid pulses, and after the last apheresis. Results: After ten steroid pulses, the visual acuity was significantly better and the pattern-reversal VEP amplitudes (element size of only 20') had a similar trend for improvement. However, this effect disappeared after seven weeks when only apheresis treatment was performed. No significant changes in the latencies of any of the tested VEP variants were found in relationship to the treatment. Conclusion: Only the observed large intra-individual variability of the VEP parameters between repeated examinations of patients with the shortest duration of GO might be recognized as a marker for functional changes of the visual pathway due to GO. Although this pilot study cannot provide a definite view on the usefulness of the extended set of VEPs in objective monitoring of GO, it seems that the steroid pulse therapy effect is detectable in contrast to the lack of influence by apheresis on the electrophysiological parameters tested. Objective: The aim of this pilot study was to evaluate the efficacy of visual evoked potentials (VEPs) in the monitoring of visual function during a high-dose intravenous steroid pulse therapy and apheresis treatment of severe Graves' ophthalmopathy (GO). Patients and Research Design: Nine patients with severe and active GO were treated with high-dose Methylprednisolone (1 g/day 3 times within 1 week, then 0.5 g/day 7 times for 2 weeks) combined with plasma filtration (twice a week in weeks 1, 2, 4, 7, and 10). Pattern-reversal and motion-onset VEPs were examined three times, pre-treatment, after steroid pulses, and after the last apheresis. Results: After ten steroid pulses, the visual acuity was significantly better and the pattern-reversal VEP amplitudes (element size of only 20') had a similar trend for improvement. However, this effect disappeared after seven weeks when only apheresis treatment was performed. No significant changes in the latencies of any of the tested VEP variants were found in relationship to the treatment. Conclusion: Only the observed large intra-individual variability of the VEP parameters between repeated examinations of patients with the shortest duration of GO might be recognized as a marker for functional changes of the visual pathway due to GO. Although this pilot study cannot provide a definite view on the usefulness of the extended set of VEPs in objective monitoring of GO, it seems that the steroid pulse therapy effect is detectable in contrast to the lack of influence by apheresis on the electrophysiological parameters tested.
dcterms:title
A pilot study to monitor Graves' Ophthalmopathy with a combination of pattern-reversal and motion-onset visual evoked potentials A pilot study to monitor Graves' Ophthalmopathy with a combination of pattern-reversal and motion-onset visual evoked potentials
skos:prefLabel
A pilot study to monitor Graves' Ophthalmopathy with a combination of pattern-reversal and motion-onset visual evoked potentials A pilot study to monitor Graves' Ophthalmopathy with a combination of pattern-reversal and motion-onset visual evoked potentials
skos:notation
RIV/00216208:11150/12:10125479!RIV13-MSM-11150___
n17:predkladatel
n18:orjk%3A11150
n4:aktivita
n14:I n14:P
n4:aktivity
I, P(GA309/09/0869)
n4:cisloPeriodika
6
n4:dodaniDat
n15:2013
n4:domaciTvurceVysledku
n5:8818649 n5:3063038 n5:9736344 n5:1987453 n5:9050051
n4:druhVysledku
n10:J
n4:duvernostUdaju
n8:S
n4:entitaPredkladatele
n11:predkladatel
n4:idSjednocenehoVysledku
120510
n4:idVysledku
RIV/00216208:11150/12:10125479
n4:jazykVysledku
n21:eng
n4:klicovaSlova
plasma filtration; glucocorticoids; Visual evoked potentials (VEP); Graves' ophthalmopathy (GO)
n4:klicoveSlovo
n7:glucocorticoids n7:Visual%20evoked%20potentials%20%28VEP%29 n7:plasma%20filtration n7:Graves%27%20ophthalmopathy%20%28GO%29
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[E00FFE65D3F2]
n4:nazevZdroje
Journal of Clinical Apheresis
n4:obor
n16:FH
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
5
n4:projekt
n13:GA309%2F09%2F0869
n4:rokUplatneniVysledku
n15:2012
n4:svazekPeriodika
27
n4:tvurceVysledku
Langrová, Jana Kuba, Miroslav Kubová, Zuzana Kremláček, Jan Szanyi, Jana
n4:wos
000312139800002
s:issn
0733-2459
s:numberOfPages
7
n12:doi
10.1002/jca.21243
n19:organizacniJednotka
11150