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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F10%3A10081061%21RIV11-GA0-11150___
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Adult human dental pulp contains stem cells (DPSCs) that are capable of differentiation into osteoblasts, odontoblasts,adipocytes, and neuronal-like cells. Because these cells have potential use in tissue regeneration, herein we characterized the response of DPSC lines to ionizing radiation (IR). These DPSC lines have been developed from the extracted molars of healthy donors. DPSCs were cultivated in a unique media supplemented with epidermal growth factor (EGF) and platelet-derived growth factor (PDGF). Since tissue homeostasis depends on a precise balance among cell proliferation, senescence, and cell death, we explored the effects of IR (2-20 Gy) on the proliferative activity of DPSCs and the molecular pathways involved. Even the highest dose used (20 Gy) did notinduce DPSC apoptosis. After irradiation with doses of 6 and 20 Gy, DPSCs accumulated in the G2 phase of the cell cycle. Adult human dental pulp contains stem cells (DPSCs) that are capable of differentiation into osteoblasts, odontoblasts,adipocytes, and neuronal-like cells. Because these cells have potential use in tissue regeneration, herein we characterized the response of DPSC lines to ionizing radiation (IR). These DPSC lines have been developed from the extracted molars of healthy donors. DPSCs were cultivated in a unique media supplemented with epidermal growth factor (EGF) and platelet-derived growth factor (PDGF). Since tissue homeostasis depends on a precise balance among cell proliferation, senescence, and cell death, we explored the effects of IR (2-20 Gy) on the proliferative activity of DPSCs and the molecular pathways involved. Even the highest dose used (20 Gy) did notinduce DPSC apoptosis. After irradiation with doses of 6 and 20 Gy, DPSCs accumulated in the G2 phase of the cell cycle.
dcterms:title
Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis
skos:prefLabel
Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis
skos:notation
RIV/00216208:11150/10:10081061!RIV11-GA0-11150___
n4:aktivita
n14:P n14:V
n4:aktivity
P(GA304/09/1568), P(NR9182), V
n4:cisloPeriodika
12
n4:dodaniDat
n15:2011
n4:domaciTvurceVysledku
n9:8061947 n9:9433597 n9:7044437 n9:6518672 n9:9990801 n9:5403065 n9:1848445 n9:6628249 n9:5439426 n9:8982007
n4:druhVysledku
n10:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n7:predkladatel
n4:idSjednocenehoVysledku
264944
n4:idVysledku
RIV/00216208:11150/10:10081061
n4:jazykVysledku
n11:eng
n4:klicovaSlova
senescence; cell cycle arest; p53; irradiation; Human Dental Pulp Stem Cells
n4:klicoveSlovo
n13:p53 n13:Human%20Dental%20Pulp%20Stem%20Cells n13:senescence n13:irradiation n13:cell%20cycle%20arest
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[CEEDDF74BBEE]
n4:nazevZdroje
Stem Cells and Development
n4:obor
n8:CE
n4:pocetDomacichTvurcuVysledku
10
n4:pocetTvurcuVysledku
12
n4:projekt
n17:NR9182 n17:GA304%2F09%2F1568
n4:rokUplatneniVysledku
n15:2010
n4:svazekPeriodika
19
n4:tvurceVysledku
Ćmielová, Jana Muthná, Darina Havelek, Radim Suchánek, Jakub Jiroutová, Alena Mokrý, Jaroslav Řezáčová, Martina Vávrová, Jiřina English, Denis Filip, Stanislav Víšek, Benjamín Soukup, Tomáš
n4:wos
000284626400004
s:issn
1547-3287
s:numberOfPages
8
n6:organizacniJednotka
11150