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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F10%3A10072265%21RIV11-MSM-11150___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Selenite-induced oxidative stress and its relationship to mitochondrial apoptosis was studied in human adenocarcinoma HT-29 cells. It is shown that selenite induces caspase-dependent apoptosis, which is mediated by mitochondria via released cytochrome c, apoptosis-inducing factor (AIF) and Smac/Diablo. Selenite activates stress kinases p38 and JNK while suppressing reduced glutathione (GSH) and thioredoxin reductase (TrxR) levels, transiently inducing heme oxygenase (HO-1) system as well as reducing Akt expression. Pre-treatment of cells with selected antioxidants and stress kinase inhibitors significantly prevented selenite-induced cell death, thereby implicating oxidative stress as a direct (Bax) as well as indirect (via kinases) cause of HT-29 cells demise. These results thus demonstrate for the first time active proapoptotic and anti-survival effects of selenite in colon cancer cells. Selenite-induced oxidative stress and its relationship to mitochondrial apoptosis was studied in human adenocarcinoma HT-29 cells. It is shown that selenite induces caspase-dependent apoptosis, which is mediated by mitochondria via released cytochrome c, apoptosis-inducing factor (AIF) and Smac/Diablo. Selenite activates stress kinases p38 and JNK while suppressing reduced glutathione (GSH) and thioredoxin reductase (TrxR) levels, transiently inducing heme oxygenase (HO-1) system as well as reducing Akt expression. Pre-treatment of cells with selected antioxidants and stress kinase inhibitors significantly prevented selenite-induced cell death, thereby implicating oxidative stress as a direct (Bax) as well as indirect (via kinases) cause of HT-29 cells demise. These results thus demonstrate for the first time active proapoptotic and anti-survival effects of selenite in colon cancer cells.
dcterms:title
ROS mediate selenite-induced apoptosis in colon cancer cells ROS mediate selenite-induced apoptosis in colon cancer cells
skos:prefLabel
ROS mediate selenite-induced apoptosis in colon cancer cells ROS mediate selenite-induced apoptosis in colon cancer cells
skos:notation
RIV/00216208:11150/10:10072265!RIV11-MSM-11150___
n3:aktivita
n8:Z
n3:aktivity
Z(MSM0021620820)
n3:cisloPeriodika
2
n3:dodaniDat
n10:2011
n3:domaciTvurceVysledku
n7:1249746 n7:2168928 n7:2650673
n3:druhVysledku
n17:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
285847
n3:idVysledku
RIV/00216208:11150/10:10072265
n3:jazykVysledku
n14:eng
n3:klicovaSlova
HO-1; Smac/Diablo; ROS; kinases; colon cancer; mitochondria; Selenite
n3:klicoveSlovo
n4:ROS n4:colon%20cancer n4:Selenite n4:Smac%2FDiablo n4:mitochondria n4:HO-1 n4:kinases
n3:kodStatuVydavatele
PL - Polská republika
n3:kontrolniKodProRIV
[C82A305A390F]
n3:nazevZdroje
Central European Journal of Biology
n3:obor
n12:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n10:2010
n3:svazekPeriodika
5
n3:tvurceVysledku
Červinka, Miroslav Rudolf, Emil Králová, Věra
n3:wos
000275141000004
n3:zamer
n18:MSM0021620820
s:issn
1895-104X
s:numberOfPages
12
n11:organizacniJednotka
11150