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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F09%3A00208621%21RIV10-MZ0-11150___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
The therapy with non-steroidal anti-inflammatory drugs is often accompanied with adverse effects in gastrointestinal tract. Aim of this experimental study was to define the time range of the creation of indomethacin-induced gastrointestinal lesions in rat. The gradual development of lesions was observed 6 hours in stomach and 24-72 hours in the intestine after the indomethacin administration. Not only the gradual development of pathophysiological alterations was observed but also the reparative phase (in the stomach). 24 hours seem to be advisable time suitable for the evaluation of the probiotics effecs as a potential therapy on the indomethacine-induced gastrointestinal lesions in rats. The therapy with non-steroidal anti-inflammatory drugs is often accompanied with adverse effects in gastrointestinal tract. Aim of this experimental study was to define the time range of the creation of indomethacin-induced gastrointestinal lesions in rat. The gradual development of lesions was observed 6 hours in stomach and 24-72 hours in the intestine after the indomethacin administration. Not only the gradual development of pathophysiological alterations was observed but also the reparative phase (in the stomach). 24 hours seem to be advisable time suitable for the evaluation of the probiotics effecs as a potential therapy on the indomethacine-induced gastrointestinal lesions in rats.
dcterms:title
Type and distribution of indomethacin-induced lesions in the gastrointestinal tract of rat Type and distribution of indomethacin-induced lesions in the gastrointestinal tract of rat
skos:prefLabel
Type and distribution of indomethacin-induced lesions in the gastrointestinal tract of rat Type and distribution of indomethacin-induced lesions in the gastrointestinal tract of rat
skos:notation
RIV/00216208:11150/09:00208621!RIV10-MZ0-11150___
n3:aktivita
n10:Z n10:P
n3:aktivity
P(GA305/08/0535), Z(MZ0FNHK2005)
n3:cisloPeriodika
Suppl. 1
n3:dodaniDat
n13:2010
n3:domaciTvurceVysledku
n17:6725856
n3:druhVysledku
n16:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
347233
n3:idVysledku
RIV/00216208:11150/09:00208621
n3:jazykVysledku
n18:eng
n3:klicovaSlova
indomethacin; non-steroidal anti-inflammatory drugs; gastrointestinal lesions; rat; macroscopy/microscopy
n3:klicoveSlovo
n5:gastrointestinal%20lesions n5:macroscopy%2Fmicroscopy n5:rat n5:non-steroidal%20anti-inflammatory%20drugs n5:indomethacin
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[8AE5CC61EDC2]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n8:FE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
3
n3:projekt
n4:GA305%2F08%2F0535
n3:rokUplatneniVysledku
n13:2009
n3:svazekPeriodika
30
n3:tvurceVysledku
Bureš, Jan Květina, Jaroslav Kuneš, Martin
n3:wos
000275266600019
n3:zamer
n19:MZ0FNHK2005
s:issn
0172-780X
s:numberOfPages
5
n15:organizacniJednotka
11150