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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F08%3A00106989%21RIV09-MSM-11150___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Studie negativní komponenty ERP vyvolané změnou v sérii uniformních zvukových podnětů je známa jako mismatch negativita (MMN). U pacientů se schizofrenií je její generování deficitní. Tento deficit je spojen se zhoršeným každodenním fungováním a může být interpretován jako marker progrese schizofrenního onemocnění. MMN vyvolaná zrakovými podněty (vMMN) byla popsána několika výzkumnými týmy, ale u pacientů se schizofrenií dosud studována nebyla. Použitím pohybových stimulací jsme vyvolali zrakovou MMN u 24 pacientů se schizofrenií. Skupinu pacientů jsem porovnali se skupinou zdravých kontrol. U skupiny nemocných byla zjištěna statisticky významně menší vMMN. V dalších analýzách byl zjištěn vztah mezi deficitní vMMN a vyšší dávkou medikace, nižší úrovní fungování a přítomností deficitního syndromu. Studies of an ERP negative amplitude deflection elicited by a change in a series of auditory stimuli is known as mismatch negativity (MMN). The generation of MMN is impaired in schizophrenia. Its deficit is associated with lower everyday functioning and may be also interpreted as the marker of progression in schizophrenia. MMN elicited by visual stimuli (vMMN) was described by several research teams, but it has not been investigated in schizophrenia as yet. Using a motion-direction paradigm, we elicited visual MMN in 24 patients with schizophrenia and schizoaffective disorder. They were compared between groups of patients with schizophrenia and healthy controls. The significantly smaller vMMN indicated an impaired generation of MMN in patients with schizophrenia. In secondary analyses there was an association of vMMN impairment among patients with higher dose of medication, lower level of functioning and the presence of deficit syndrome. Studies of an ERP negative amplitude deflection elicited by a change in a series of auditory stimuli is known as mismatch negativity (MMN). The generation of MMN is impaired in schizophrenia. Its deficit is associated with lower everyday functioning and may be also interpreted as the marker of progression in schizophrenia. MMN elicited by visual stimuli (vMMN) was described by several research teams, but it has not been investigated in schizophrenia as yet. Using a motion-direction paradigm, we elicited visual MMN in 24 patients with schizophrenia and schizoaffective disorder. They were compared between groups of patients with schizophrenia and healthy controls. The significantly smaller vMMN indicated an impaired generation of MMN in patients with schizophrenia. In secondary analyses there was an association of vMMN impairment among patients with higher dose of medication, lower level of functioning and the presence of deficit syndrome.
dcterms:title
Zraková mismatch negativita u pacientů se schizofrenií Visual mismatch negativity in deficit and nondeficit schizophrenia Visual mismatch negativity in deficit and nondeficit schizophrenia
skos:prefLabel
Zraková mismatch negativita u pacientů se schizofrenií Visual mismatch negativity in deficit and nondeficit schizophrenia Visual mismatch negativity in deficit and nondeficit schizophrenia
skos:notation
RIV/00216208:11150/08:00106989!RIV09-MSM-11150___
n3:aktivita
n10:Z n10:S
n3:aktivity
S, Z(MSM0021620816)
n3:dodaniDat
n14:2009
n3:domaciTvurceVysledku
n4:5969034 n4:8818649 n4:9736344 n4:2617536 n4:5023408
n3:druhVysledku
n15:D
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
402806
n3:idVysledku
RIV/00216208:11150/08:00106989
n3:jazykVysledku
n16:eng
n3:klicovaSlova
schizophrenia; event related potentials; mismatch negativity; visual mismatch negativity; information processing
n3:klicoveSlovo
n9:visual%20mismatch%20negativity n9:event%20related%20potentials n9:information%20processing n9:schizophrenia n9:mismatch%20negativity
n3:kontrolniKodProRIV
[291796984F8A]
n3:mistoVydani
Praha
n3:nazevZdroje
Quo vadis, psychiatria?
n3:obor
n8:FL
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n14:2008
n3:tvurceVysledku
Urban, Aleš Libiger, Jan Kremláček, Jan Kuba, Miroslav Masopust, Jiří
n3:zamer
n13:MSM0021620816
s:numberOfPages
1
n12:hasPublisher
Galén
n7:isbn
978-80-7262-567-3
n19:organizacniJednotka
11150