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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F08%3A00106537%21RIV09-MSM-11150___
rdf:type
skos:Concept n6:Vysledek
dcterms:description
Zinc has been shown to have inhibitory effects on proliferation and metabolism of malignant colonocytes. Still, there is no information available concerning putative effects of zinc against motility and migration of colon cancer cells. Using fluorescence microscopy, immunoblotting and microfluorimetry we show that treatment with zinc sulfate affected motility, invasiveness, cytoskeletal integrity and expression of selected markers (E-cadherin, catenin, vimentin, tubulin and actin) of invasive SW480 colon tumor cells. These results emphasize the possible multitudinous role of zinc in the process of colon cancer development and hint at the potential of this element in chemoprevention of advanced colorectal carcinoma. Zinc has been shown to have inhibitory effects on proliferation and metabolism of malignant colonocytes. Still, there is no information available concerning putative effects of zinc against motility and migration of colon cancer cells. Using fluorescence microscopy, immunoblotting and microfluorimetry we show that treatment with zinc sulfate affected motility, invasiveness, cytoskeletal integrity and expression of selected markers (E-cadherin, catenin, vimentin, tubulin and actin) of invasive SW480 colon tumor cells. These results emphasize the possible multitudinous role of zinc in the process of colon cancer development and hint at the potential of this element in chemoprevention of advanced colorectal carcinoma. Bylo prokázáno, že zinek má inhibiční účinky na proliferaci a metabolismus maligních kolonocytů. I přesto neexistují informace o jeho účincích na motilitu a migraci těchto buněk. Za pomoci fluorescenční mikroskopie imunoblotingu a mikroflurometrie dokazujeme, že síran zinečnatý ovlivňuje motilitu, invazivitu, integritu cytoskeletu a expresi vybraných markerů (E-kadherin, katenin, vimentin, tubulin a aktin) u invazivních buněk linie SW480. Tyto výsledky podtrhují možnou flexibilní úlohu zinku v procesu kolorektální karcinogeneze a naznačují chemopreventivní potenciál tohoto prvku u rozvinutého kolorektálního karcinomu.
dcterms:title
Zinek ovlivňje integritu a migraci nádorových buněk kolorekta Zinc alters cytoskeletal integrity and migration in colon cancer cells Zinc alters cytoskeletal integrity and migration in colon cancer cells
skos:prefLabel
Zinc alters cytoskeletal integrity and migration in colon cancer cells Zinc alters cytoskeletal integrity and migration in colon cancer cells Zinek ovlivňje integritu a migraci nádorových buněk kolorekta
skos:notation
RIV/00216208:11150/08:00106537!RIV09-MSM-11150___
n7:aktivita
n14:Z
n7:aktivity
Z(MSM0021620820)
n7:cisloPeriodika
1
n7:dodaniDat
n10:2009
n7:domaciTvurceVysledku
n15:2650673 n15:1249746
n7:druhVysledku
n9:J
n7:duvernostUdaju
n13:S
n7:entitaPredkladatele
n16:predkladatel
n7:idSjednocenehoVysledku
406815
n7:idVysledku
RIV/00216208:11150/08:00106537
n7:jazykVysledku
n11:eng
n7:klicovaSlova
SW480 cells; migration; invasion; cytoskeleton; microtubules
n7:klicoveSlovo
n8:cytoskeleton n8:migration n8:SW480%20cells n8:invasion n8:microtubules
n7:kodStatuVydavatele
CZ - Česká republika
n7:kontrolniKodProRIV
[EEFEF3F7BBC6]
n7:nazevZdroje
Acta Medica (Hradec Králové)
n7:obor
n17:EB
n7:pocetDomacichTvurcuVysledku
2
n7:pocetTvurcuVysledku
4
n7:rokUplatneniVysledku
n10:2008
n7:svazekPeriodika
51
n7:tvurceVysledku
John, Stanislav Klvačová, Lada Rudolf, Emil Červinka, Miroslav
n7:zamer
n18:MSM0021620820
s:issn
1211-4286
s:numberOfPages
7
n12:organizacniJednotka
11150