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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F08%3A00106514%21RIV09-MZ0-11150___
rdf:type
skos:Concept n9:Vysledek
dcterms:description
The immunohistochemical exppression of galectin-3 (Gal3), cytokeratin (CK19), neural cell adhesion molecule (NCAM), and E-cadherin (Ecad) was evaluated to assess their use in diagnostics of papillary thyroid carcinoma (PTC) A total of 84 PTCs - 36 classical variants (cPTCs), 26 follicular variants (fPTCs), and 22 papillary microcarcinomas (mPTCs) were studied. A significant difference in CK19 expression was observed between cPTC and both fPTC and mPTC (p<0,001). Furthemore, extrathyroid tumor spread significantly correlated with both level of CK19 expression and loss of Ecad expression (p=0,001, p=0,04). Our findings suggest that Gal3 and CK19 are useful markers for PTC, although decreased CK19 expression in mPTC and fPTC must be considered. Furthemore, CK19 and Ecad may play a role in extrathyroid tumor spread. The immunohistochemical exppression of galectin-3 (Gal3), cytokeratin (CK19), neural cell adhesion molecule (NCAM), and E-cadherin (Ecad) was evaluated to assess their use in diagnostics of papillary thyroid carcinoma (PTC) A total of 84 PTCs - 36 classical variants (cPTCs), 26 follicular variants (fPTCs), and 22 papillary microcarcinomas (mPTCs) were studied. A significant difference in CK19 expression was observed between cPTC and both fPTC and mPTC (p<0,001). Furthemore, extrathyroid tumor spread significantly correlated with both level of CK19 expression and loss of Ecad expression (p=0,001, p=0,04). Our findings suggest that Gal3 and CK19 are useful markers for PTC, although decreased CK19 expression in mPTC and fPTC must be considered. Furthemore, CK19 and Ecad may play a role in extrathyroid tumor spread. Cílem studie bylo pomocí nepřímé imunohistochemie zjistit expresi galektinu-3 (Gal3), cytokeratinu 19 (CK19), neural cell adhesion molecule (NCAM) a E-cadherinu (Ecad) ve variantách papilárního karcinomu štítné žlázy (PTC) s ohledem na možné využití těchto markerů v bioptické diagnostice. Soubor tvořilo 84 případů - 36 klasických variant PTC (cPTC), 26 folikulárních variant PTC (fPTC) a 22 papilárních mikrokarcinomů (mPTC). V expresi CK19 byl zjištěn signifikantní rozdíl mezi cPTC versus fPTC a mPTC (p<0,001). Dále byla prokázána signifikantní korelace mezi expresí CK19 a ztrátou exprese Ecad ve vztahu k šíření nádoru mimo štítnou žlázu (p=0,001, p=0,04). Detekci exprese Gal3 a CK19 lze tedy doporučit jako pomocné kritérium v daigbnostice PTC, nicméně je třeba upozornit na nižší expersi CK19 ve fPTC a v mPTC. K detailnímu posouzení úlohy CK19 a Ecad při šíření PTC mimo štítnou žlázu je třeba dalších studií.
dcterms:title
Expression of Galectin-3, Cytokeratin 19, Neural Cell Adhesion Molecule and E-cadherin in Certain Variants of Papillary Thyroid Carcinoma Exprese galectinu-3, cytokeratinu 19, neural cell adhesion molecule a E-cadherinu ve variantách papilárního karcinomu štítné žlázy Expression of Galectin-3, Cytokeratin 19, Neural Cell Adhesion Molecule and E-cadherin in Certain Variants of Papillary Thyroid Carcinoma
skos:prefLabel
Expression of Galectin-3, Cytokeratin 19, Neural Cell Adhesion Molecule and E-cadherin in Certain Variants of Papillary Thyroid Carcinoma Exprese galectinu-3, cytokeratinu 19, neural cell adhesion molecule a E-cadherinu ve variantách papilárního karcinomu štítné žlázy Expression of Galectin-3, Cytokeratin 19, Neural Cell Adhesion Molecule and E-cadherin in Certain Variants of Papillary Thyroid Carcinoma
skos:notation
RIV/00216208:11150/08:00106514!RIV09-MZ0-11150___
n3:aktivita
n14:Z
n3:aktivity
Z(MZ0FNHK2005)
n3:cisloPeriodika
4
n3:dodaniDat
n13:2009
n3:domaciTvurceVysledku
n7:6953891 n7:6988288 n7:1141147 n7:6097049
n3:druhVysledku
n18:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
367423
n3:idVysledku
RIV/00216208:11150/08:00106514
n3:jazykVysledku
n12:eng
n3:klicovaSlova
papillary thyroid carcinoma; galectin-3; cytokeratin 19; neural cell adhesion molecule; E cadherin
n3:klicoveSlovo
n6:neural%20cell%20adhesion%20molecule n6:E%20cadherin n6:galectin-3 n6:cytokeratin%2019 n6:papillary%20thyroid%20carcinoma
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[1DE65B0ABB66]
n3:nazevZdroje
Česko-slovenská patologie a Soudní lékařství
n3:obor
n15:FP
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n13:2008
n3:svazekPeriodika
44
n3:tvurceVysledku
Čelakovský, Petr Ryška, Aleš Čáp, Jan Laco, Jan
n3:zamer
n4:MZ0FNHK2005
s:issn
1210-7875
s:numberOfPages
5
n10:organizacniJednotka
11150