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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F07%3A00003697%21RIV08-MSM-11150___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Administration of antipsychotics appears to be related to increased risk of venous thromboembolism and cerebrovascular side effects. The biological mechanism responsible for this possible adverse drug reaction is unknown, but there is a growing number of elucidating hypotheses. Treatment with antipsychotics is a asssociated with elevation of prolactin level. Prolactin has recently been recognized as potent platelet aggregation co-activator, and have therefore been postulated as an addditional risk factor for both arterial and venous thrombosis. We briefly review the arguments for the role of hyperprolactinemia in pathogenesis of platelet aggregation. Administration of antipsychotics appears to be related to increased risk of venous thromboembolism and cerebrovascular side effects. The biological mechanism responsible for this possible adverse drug reaction is unknown, but there is a growing number of elucidating hypotheses. Treatment with antipsychotics is a asssociated with elevation of prolactin level. Prolactin has recently been recognized as potent platelet aggregation co-activator, and have therefore been postulated as an addditional risk factor for both arterial and venous thrombosis. We briefly review the arguments for the role of hyperprolactinemia in pathogenesis of platelet aggregation. Podávání antipsychotik se zdá být ve vztahu ke zvýšenému riziku žilního tromboembolismu a cerebrovaskulárním nežádoucím účinkům. Zatím jsou biologické mechanismy těchto nežádoucích účinků neznámé. Při léčbě antipsychotiky však vzrůstá hladina prolaktinu. Prolaktin je koaktivátorem srážení krevních destiček. Představuje tedy rizikový faktor pro arteriální a žilní trombózu. Krátce shrnujeme údaje o roli hyperprolaktinemie v patogenezi srážení krevních destiček.
dcterms:title
Prolactin as a factor for increased platelet aggregation Prolactin as a factor for increased platelet aggregation Prolaktin jako faktor zvýšeného srážení krevních destiček
skos:prefLabel
Prolaktin jako faktor zvýšeného srážení krevních destiček Prolactin as a factor for increased platelet aggregation Prolactin as a factor for increased platelet aggregation
skos:notation
RIV/00216208:11150/07:00003697!RIV08-MSM-11150___
n3:strany
101;106
n3:aktivita
n13:Z
n3:aktivity
Z(MSM0021620816), Z(MZ0FNHK2005)
n3:cisloPeriodika
4
n3:dodaniDat
n15:2008
n3:domaciTvurceVysledku
n8:5969034 n8:5023408 n8:8573409 n8:6682391 n8:5697905
n3:druhVysledku
n17:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
445302
n3:idVysledku
RIV/00216208:11150/07:00003697
n3:jazykVysledku
n9:eng
n3:klicovaSlova
prolactin; hyperprolactinemia; platelet activation; platelet aggregation; antipsychotics; venous thrombosis; cerebrovascular complications
n3:klicoveSlovo
n5:platelet%20activation n5:prolactin n5:antipsychotics n5:cerebrovascular%20complications n5:venous%20thrombosis n5:hyperprolactinemia n5:platelet%20aggregation
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[0E30A643391A]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n18:FL
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n15:2007
n3:svazekPeriodika
28
n3:tvurceVysledku
Hosák, Ladislav Kalnická, Dita Masopust, Jiří Malý, Radovan Urban, Aleš
n3:zamer
n6:MSM0021620816 n6:MZ0FNHK2005
s:issn
0172-780X
s:numberOfPages
6
n16:organizacniJednotka
11150