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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F06%3A00005147%21RIV08-MSM-11150___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Our pilot study aimed to determine the effect of tumor necrosis factor-alpha (TNF-alfa) 308 G?A promoter single-nucleotide polymorphism in pediatric inflammatory bowel disease (IBD), its influence on inflammatory activity and the clinical manifestations. METHODS: We obtained genomic DNA from 164 subjects, 82 with long-standing IBD aged 8 to 18 years: 46 with Crohn disease (CD) and 36 with ulcerative colitis (UC). CONCLUSIONS: Although not necessarily dictating IBD initiation, the TNF-alfa 308 A polymorphism may play a role in modifying the CD phenotype. The polymorphism may influence disease activity as well as more intense inflammatory activity in both forms of IBD and may modify the progression of chronic digestive tract inflammation. Our pilot study aimed to determine the effect of tumor necrosis factor-alpha (TNF-alfa) 308 G?A promoter single-nucleotide polymorphism in pediatric inflammatory bowel disease (IBD), its influence on inflammatory activity and the clinical manifestations. METHODS: We obtained genomic DNA from 164 subjects, 82 with long-standing IBD aged 8 to 18 years: 46 with Crohn disease (CD) and 36 with ulcerative colitis (UC). CONCLUSIONS: Although not necessarily dictating IBD initiation, the TNF-alfa 308 A polymorphism may play a role in modifying the CD phenotype. The polymorphism may influence disease activity as well as more intense inflammatory activity in both forms of IBD and may modify the progression of chronic digestive tract inflammation. Cíle: naše pilotní studie si dala za cíl určit účinky jednonukleotidového promotorového polymorfizmu tumor-nekrotizujícího faktoru-alfa (TNF-alfa) 308 G?A v pediatrické zánětlivé chorobě střev (IBD), jeho vliv na zánětlivou aktivitu a klinickou manifestaci. Metody: genomická DNA od 164 subjektů (věk 8-18 let) - 82 s dlouhodobou IBD; 46 s Crohnovou chorobou (CD); 36 s ulcerativní kolitidou (UC); 82 zdravých kontrol byla genotypována pomocí testu restrikčních enzymů a polymorfizmus byl určen ve smyslu aktivity C-reaktivního proteinu a vlastní aktivity nemoci. Výsledky: byly nalezeny významné rozdíly v polymorfizmu (TNF-?) 308 G?A mezi IBD a kontrolami a UC a kontrolami. Frekvence TNF-alfa 308 A genotypu byla významně vyšší u pacientů s CD s penetrující chorobou v porovnání s pacienty bez komplikací a zdravými kontrolami. Distribuce alel a hladiny CRP byly nezávisle spojeny s CD komplikacemi. Závěry: TNF-alfa 308 A polymorfizmus může hrát úlohu při modifikaci CD fenotypu
dcterms:title
Cytokine Tumor Necrosis Factor-alpha A Promoter Gene Polymorphism at Position - 308 G-->A and Pediatric Inflammatory Bowel Disease: Implications in Ulcerative Colitis and Crohn´s Disease Cytokine Tumor Necrosis Factor-alpha A Promoter Gene Polymorphism at Position-308 G-->A and Pediatric Inflammatory Bowel Disease: Implications in Ulcerative Colitis and Crohn´s Disease Cytokine Tumor Necrosis Factor-alpha A Promoter Gene Polymorphism at Position-308 G-->A and Pediatric Inflammatory Bowel Disease: Implications in Ulcerative Colitis and Crohn´s Disease
skos:prefLabel
Cytokine Tumor Necrosis Factor-alpha A Promoter Gene Polymorphism at Position-308 G-->A and Pediatric Inflammatory Bowel Disease: Implications in Ulcerative Colitis and Crohn´s Disease Cytokine Tumor Necrosis Factor-alpha A Promoter Gene Polymorphism at Position - 308 G-->A and Pediatric Inflammatory Bowel Disease: Implications in Ulcerative Colitis and Crohn´s Disease Cytokine Tumor Necrosis Factor-alpha A Promoter Gene Polymorphism at Position-308 G-->A and Pediatric Inflammatory Bowel Disease: Implications in Ulcerative Colitis and Crohn´s Disease
skos:notation
RIV/00216208:11150/06:00005147!RIV08-MSM-11150___
n4:strany
479;487
n4:aktivita
n6:V n6:S
n4:aktivity
S, V
n4:cisloPeriodika
5
n4:dodaniDat
n16:2008
n4:domaciTvurceVysledku
n12:5544750 n12:8575541
n4:druhVysledku
n10:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
470261
n4:idVysledku
RIV/00216208:11150/06:00005147
n4:jazykVysledku
n11:eng
n4:klicovaSlova
Cytokine; Tumor; Necrosis; Factor-alpha; Promoter; Polymorphism; Position-308; Pediatric; Inflammatory; Bowel; Disease; Implications; Ulcerative; Colitis; Crohn´s; Disease
n4:klicoveSlovo
n5:Necrosis n5:Crohn%C2%B4s n5:Pediatric n5:Inflammatory n5:Factor-alpha n5:Polymorphism n5:Bowel n5:Colitis n5:Position-308 n5:Implications n5:Cytokine n5:Tumor n5:Disease n5:Ulcerative n5:Promoter
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[5E27C39C16A2]
n4:nazevZdroje
Journal of Pediatric Gastroenterology and Nutrition
n4:obor
n14:FG
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
10
n4:rokUplatneniVysledku
n16:2006
n4:svazekPeriodika
42
n4:tvurceVysledku
Pozler, Oldřich Dědek, Petr
s:issn
0277-2116
s:numberOfPages
9
n15:organizacniJednotka
11150