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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F06%3A00004339%21RIV07-MSM-11150___
rdf:type
n3:Vysledek skos:Concept
dcterms:description
Amlodipin je chirální blokátor kalciových kanálů. V klinické praxi se užívá racemát, ačkoliv je známo, že vazodilatační vlastnosti vykazuje pouze S-amlodipin. Při studiu chirálních aspektů biotransformace byl s hepatocyty potkana inkubován jak racemát amlodipinu, tak oba jeho enantiomery. Identifikováno a semikvantitativně stanovováno bylo 8 metabolitů přítomných v nejvyšších koncentracích. Amlodipine is a chiral calcium channel blocker. Racemic mixture is used in clinical practice even though it is known that only S-amlodipine possess vasodilating properties. Chiral aspects of biotransformation were studied by incubation of amlodipine and its two individual enantiomers with rat hepatocytes. Eight metabolites presented in the highest amount were identified and semiquantified. Amlodipine is a chiral calcium channel blocker. Racemic mixture is used in clinical practice even though it is known that only S-amlodipine possess vasodilating properties. Chiral aspects of biotransformation were studied by incubation of amlodipine and its two individual enantiomers with rat hepatocytes. Eight metabolites presented in the highest amount were identified and semiquantified.
dcterms:title
Kapalinová chromatografie standemovou hmotnostní spektrometrií (LC-MS/MS) vchirální studii biotransformace amlodipinu hepatocyty potkana Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes
skos:prefLabel
Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes Kapalinová chromatografie standemovou hmotnostní spektrometrií (LC-MS/MS) vchirální studii biotransformace amlodipinu hepatocyty potkana Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes
skos:notation
RIV/00216208:11150/06:00004339!RIV07-MSM-11150___
n4:strany
273;283
n4:aktivita
n18:V n18:Z
n4:aktivity
V, Z(MSM0021620820)
n4:cisloPeriodika
573-574
n4:dodaniDat
n14:2007
n4:domaciTvurceVysledku
n17:9917829
n4:druhVysledku
n5:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
483414
n4:idVysledku
RIV/00216208:11150/06:00004339
n4:jazykVysledku
n8:eng
n4:klicovaSlova
liquid chromatography; LC-MS/MS; amlodipine; stereoselective metabolism; in vitro
n4:klicoveSlovo
n7:liquid%20chromatography n7:stereoselective%20metabolism n7:LC-MS%2FMS n7:amlodipine n7:in%20vitro
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[058EF4454EBA]
n4:nazevZdroje
Analytica Chimica Acta
n4:obor
n11:CE
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
3
n4:rokUplatneniVysledku
n14:2006
n4:svazekPeriodika
2006
n4:tvurceVysledku
Šišpera, Luděk
n4:zamer
n6:MSM0021620820
s:issn
0003-2670
s:numberOfPages
11
n13:organizacniJednotka
11150