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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F05%3A00003602%21RIV06-MSM-11150___
rdf:type
n13:Vysledek skos:Concept
dcterms:description
The aim of our study was to describe histopathology of the peripheral nerve after its circular release followed by embedding in different environs. We operated on 18 male rats divided into 3 groups. In the first group right femoral nerve was surgically released. In the second group the nerve was enveloped by the subcutaneous fat flap. In the third one the nerve was wrapped up by the skeletal muscle. Six weeks later the animals wire killed by exsanguination. The femoral nerve, in the first group, did not show any pathological changes. In the second group 3 animals appeared normal or nerarly normal, nevertheless in 3 of them perineural fibrosis and axonal degeneration were observed. Histological reaction in the third group disclosed dispersed axonal injury. Our experiments using rat model imitate situation in humans. The results obtained will help us in making meaningful decision when performing peripheral nerve injury. The aim of our study was to describe histopathology of the peripheral nerve after its circular release followed by embedding in different environs. We operated on 18 male rats divided into 3 groups. In the first group right femoral nerve was surgically released. In the second group the nerve was enveloped by the subcutaneous fat flap. In the third one the nerve was wrapped up by the skeletal muscle. Six weeks later the animals wire killed by exsanguination. The femoral nerve, in the first group, did not show any pathological changes. In the second group 3 animals appeared normal or nerarly normal, nevertheless in 3 of them perineural fibrosis and axonal degeneration were observed. Histological reaction in the third group disclosed dispersed axonal injury. Our experiments using rat model imitate situation in humans. The results obtained will help us in making meaningful decision when performing peripheral nerve injury. Cílem práce bylo popsat histologické změny periferních nervů po jejich uvolnění a uložení do různých tkání. Operovali jsme 18 krys (samci) rozdělených do 3 skupin. V první jsme uvolnili n. femoralis vpravo, ve druhé byl nerv obalen podkožním tukem, ve třetí byl uložen do příčně pruhovaného svalu. Zvířata byla utracena po 6 týdnech exsanquinací. V první skupině n. femoralis nevykázal žádné patologické změny, ve druhé skupině byl nález u 3 zvířat normální nebo skoro normální a u 3 z nich jsme nalezli perineurální fibrózu a degeneraci axonu. Histologické vyšetření ve třetí skupině prokázalo poškození axonu. Experimenty napodobují situaci u nemocných a získané výsledky pomohou v rozhodování o léčbě poranění periferních nervů.
dcterms:title
The changes of peripheral nerve microsutructure after surgical manipulation - experiment on rat model Změny v mikrostruktuře periferního nervu po chirurgické manipulaci - experiment na kryse The changes of peripheral nerve microsutructure after surgical manipulation - experiment on rat model
skos:prefLabel
The changes of peripheral nerve microsutructure after surgical manipulation - experiment on rat model Změny v mikrostruktuře periferního nervu po chirurgické manipulaci - experiment na kryse The changes of peripheral nerve microsutructure after surgical manipulation - experiment on rat model
skos:notation
RIV/00216208:11150/05:00003602!RIV06-MSM-11150___
n4:strany
165;172
n4:aktivita
n16:P n16:Z
n4:aktivity
P(IAA148404), P(NR8404), Z(MSM0021620820)
n4:cisloPeriodika
3
n4:dodaniDat
n6:2006
n4:domaciTvurceVysledku
n9:7852800 n9:7450273 n9:7868901 n9:7267061
n4:druhVysledku
n17:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n7:predkladatel
n4:idSjednocenehoVysledku
514934
n4:idVysledku
RIV/00216208:11150/05:00003602
n4:jazykVysledku
n11:eng
n4:klicovaSlova
Nerve microstructure; perineural fibrosis; axonal damage; animals models; nerve histology
n4:klicoveSlovo
n15:Nerve%20microstructure n15:perineural%20fibrosis n15:animals%20models n15:axonal%20damage n15:nerve%20histology
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[BEC589A26C5C]
n4:nazevZdroje
Acta Medica (Hradec Králové)
n4:obor
n10:FH
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
4
n4:projekt
n12:NR8404 n12:IAA148404
n4:rokUplatneniVysledku
n6:2005
n4:svazekPeriodika
48
n4:tvurceVysledku
Ehler, Edvard Němeček, Stanislav Cerman, Jaroslav Kanta, Martin
n4:zamer
n18:MSM0021620820
s:issn
1211-4286
s:numberOfPages
8
n14:organizacniJednotka
11150