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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F04%3A00004429%21RIV08-MSM-11150___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Selhání apoptózy při léčbě hemoblastózy cytostatiky je jednou z příčin chemorezistence. Zajímali jsme se o vztah apoptózy AML buněk po podání doxorubicinu a imunofenotypem, vybranými klinickými a laboratorními parametry a expresí proteinů P-gp, MRP, LRP, Bcl-2 a Bax. Všechny analýzy byly hodnoceny metodou průtokové cytometrie. K detekci apoptotických buněk ve vzorku byly použity 3 metody: annexin test, TUNEL (TdT-mediated dUTP nick end labeling) test a detekce kaspázy 8. Po kultivaci buněk byl zřejmý statistický nárůst apoptotických buněk v kultuře. Byl také pozorován vztah mezi in vitro blastickou reakcí AML buněk a některými klinickými parametry jako věk pacienta, počet bílých krvinek a procento blastických buněk The apoptosis failure in cytostatic treatment of haemoblastosis is one of the means of chemoresistance. We were interested in the relationship of the after-doxorubicin-treatment-AML cells apoptosis and the immunophenotype, selected clinical and laboratory parameters, and also the P-gp, MRP, LRP, Bcl-2, Bax proteins expression. All analysis were evaluated with the flow cytometry method. To detect apoptotic cells in the sample, we used three methods: annexin test, TUNEL (TdT-mediated dUTP nick end labeling) test, and caspase 8 detection. After the cell cultivation the statisticaly important increase of apoptotic cells in the culture was apparent. The relation between the AML blast in vitro reaction and some clinical parameters such as the age of patient, white blood cell count, and blast percentage was also observed. : AML; Apoptosis; Multidrug resistance; Flow cytometry The apoptosis failure in cytostatic treatment of haemoblastosis is one of the means of chemoresistance. We were interested in the relationship of the after-doxorubicin-treatment-AML cells apoptosis and the immunophenotype, selected clinical and laboratory parameters, and also the P-gp, MRP, LRP, Bcl-2, Bax proteins expression. All analysis were evaluated with the flow cytometry method. To detect apoptotic cells in the sample, we used three methods: annexin test, TUNEL (TdT-mediated dUTP nick end labeling) test, and caspase 8 detection. After the cell cultivation the statisticaly important increase of apoptotic cells in the culture was apparent. The relation between the AML blast in vitro reaction and some clinical parameters such as the age of patient, white blood cell count, and blast percentage was also observed. : AML; Apoptosis; Multidrug resistance; Flow cytometry
dcterms:title
The multidrug resistance and apoptosis evaluation in acute myeloid leukemia cells after the in vitro doxorubicin treatment Hodnocení mnohočetné lékové rezistence u buněk akutní myeloidní leukémie po ošetření doxorubicinem in vitro The multidrug resistance and apoptosis evaluation in acute myeloid leukemia cells after the in vitro doxorubicin treatment
skos:prefLabel
The multidrug resistance and apoptosis evaluation in acute myeloid leukemia cells after the in vitro doxorubicin treatment Hodnocení mnohočetné lékové rezistence u buněk akutní myeloidní leukémie po ošetření doxorubicinem in vitro The multidrug resistance and apoptosis evaluation in acute myeloid leukemia cells after the in vitro doxorubicin treatment
skos:notation
RIV/00216208:11150/04:00004429!RIV08-MSM-11150___
n3:strany
181;185
n3:aktivita
n17:S
n3:aktivity
S
n3:cisloPeriodika
3
n3:dodaniDat
n6:2008
n3:domaciTvurceVysledku
n12:8731209 n12:8222525 n12:9066799
n3:druhVysledku
n16:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
574980
n3:idVysledku
RIV/00216208:11150/04:00004429
n3:jazykVysledku
n14:eng
n3:klicovaSlova
multidrug; resistance; apoptosis; evaluation; acute; myeloid; leukemia; cells; after; vitro; doxorubicin; treatment
n3:klicoveSlovo
n5:vitro n5:resistance n5:leukemia n5:acute n5:doxorubicin n5:myeloid n5:multidrug n5:treatment n5:after n5:evaluation n5:apoptosis n5:cells
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[2A15F8ED68E6]
n3:nazevZdroje
Acta Medica (Hradec Králové)
n3:obor
n7:FN
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n6:2004
n3:svazekPeriodika
47
n3:tvurceVysledku
Novosad, Jakub Kopecký, Otakar Krejsek, Jan
s:issn
1211-4286
s:numberOfPages
5
n11:organizacniJednotka
11150