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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F04%3A00002022%21RIV10-GA0-11150___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
The aim of the present study was to evaluate using male rats the effect of short-term adrenergic blockade on the rate of whole-body protein turnover and leucine oxidation, and on protein synthesis in specific tissues. Adrenergic blockade was induced by guanethidine (100 mg/b.w. subcutaneously). There was insignificant effect of guanethidine on whole-body proteolysis, protein synthesis, and leucine clearance. However, protein balance was more negative due to the higher difference between protein synthesis and proteolysis in guanethidine treated animals than in controls. In guanethidine treated rats, protein synthesis was higher in gastrocnemius muscle and in the kidneys and lower in liver and spleen. Changes in small intestine and colon were insignificant. It is concluded that adrenergic blockade induced by guanethidine is associated with significant changes in protein metabolism, leucine oxidation and amino acid concentrations in several tissues. The aim of the present study was to evaluate using male rats the effect of short-term adrenergic blockade on the rate of whole-body protein turnover and leucine oxidation, and on protein synthesis in specific tissues. Adrenergic blockade was induced by guanethidine (100 mg/b.w. subcutaneously). There was insignificant effect of guanethidine on whole-body proteolysis, protein synthesis, and leucine clearance. However, protein balance was more negative due to the higher difference between protein synthesis and proteolysis in guanethidine treated animals than in controls. In guanethidine treated rats, protein synthesis was higher in gastrocnemius muscle and in the kidneys and lower in liver and spleen. Changes in small intestine and colon were insignificant. It is concluded that adrenergic blockade induced by guanethidine is associated with significant changes in protein metabolism, leucine oxidation and amino acid concentrations in several tissues.
dcterms:title
Protein metabolism in guanethidine-treated rats Protein metabolism in guanethidine-treated rats
skos:prefLabel
Protein metabolism in guanethidine-treated rats Protein metabolism in guanethidine-treated rats
skos:notation
RIV/00216208:11150/04:00002022!RIV10-GA0-11150___
n4:aktivita
n15:P
n4:aktivity
P(GA303/03/1512)
n4:cisloPeriodika
1
n4:dodaniDat
n10:2010
n4:domaciTvurceVysledku
n11:3031624
n4:druhVysledku
n17:J
n4:duvernostUdaju
n13:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
582863
n4:idVysledku
RIV/00216208:11150/04:00002022
n4:jazykVysledku
n18:eng
n4:klicovaSlova
adrenergic blockade; catecholamines; leucine; sympathetic system
n4:klicoveSlovo
n5:catecholamines n5:adrenergic%20blockade n5:leucine n5:sympathetic%20system
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[A7D54A15F893]
n4:nazevZdroje
International Journal of Experimental Pathology
n4:obor
n12:FB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
3
n4:projekt
n9:GA303%2F03%2F1512
n4:rokUplatneniVysledku
n10:2004
n4:svazekPeriodika
85
n4:tvurceVysledku
Holeček, Milan
n4:wos
000223997200003
s:issn
0959-9673
s:numberOfPages
8
n7:organizacniJednotka
11150