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Statements

Subject Item
n2:RIV%2F00216208%3A11140%2F14%3A10284094%21RIV15-MSM-11140___
rdf:type
skos:Concept n11:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1097/PAP.0000000000000043
dcterms:description
Glypican 3 is a membrane-bound heparan sulfate proteoglycan, which has recently been identified as a marker for liver cancer and germ cell malignancies. Individuals with loss-of-function mutations for the glypican 3 gene exhibit Simpson-Golabi-Behmel syndrome, a rare X-linked overgrowth disorder. Expression of glypican 3 mRNA and protein is normally silenced in most adult organs and may reappear during malignant transformation. In the past few years, immunohistochemical and molecular characteristics of glypican 3 in hepatocellular carcinoma have been elucidated. More recently, glypican 3 has been emerging as a new diagnostic marker for germ cell tumors and especially testicular and ovarian yolk sac tumors. However, in other tumors such as renal cell carcinomas, squamous cell carcinomas, and melanomas, studies disagree on the level of glypican 3 expression. Finally, there is the controversial notion of glypican 3 as a tumor suppressor gene. In this review article, we update current knowledge on glypican 3 expression in normal and neoplastic tissues, evaluate its utility as a tumor marker in clinical practice, and explore its role as a novel oncofetal protein with clinical implications. Our focus is on the diagnostic value of glypican 3 in germ cell tumors and other neoplasms in addition to hepatocellular carcinoma. In conclusion, glypican 3 has been proven to be a useful immunohistochemical marker in distinguishing yolk sac tumors, choriocarcinomas, and Wilms tumors from other malignancies histologically mimicking these primitive tumors. Clinically, we recommend that glypican 3 be used as part of a panel of markers in subtyping testicular germ cell tumors. Glypican 3 is a membrane-bound heparan sulfate proteoglycan, which has recently been identified as a marker for liver cancer and germ cell malignancies. Individuals with loss-of-function mutations for the glypican 3 gene exhibit Simpson-Golabi-Behmel syndrome, a rare X-linked overgrowth disorder. Expression of glypican 3 mRNA and protein is normally silenced in most adult organs and may reappear during malignant transformation. In the past few years, immunohistochemical and molecular characteristics of glypican 3 in hepatocellular carcinoma have been elucidated. More recently, glypican 3 has been emerging as a new diagnostic marker for germ cell tumors and especially testicular and ovarian yolk sac tumors. However, in other tumors such as renal cell carcinomas, squamous cell carcinomas, and melanomas, studies disagree on the level of glypican 3 expression. Finally, there is the controversial notion of glypican 3 as a tumor suppressor gene. In this review article, we update current knowledge on glypican 3 expression in normal and neoplastic tissues, evaluate its utility as a tumor marker in clinical practice, and explore its role as a novel oncofetal protein with clinical implications. Our focus is on the diagnostic value of glypican 3 in germ cell tumors and other neoplasms in addition to hepatocellular carcinoma. In conclusion, glypican 3 has been proven to be a useful immunohistochemical marker in distinguishing yolk sac tumors, choriocarcinomas, and Wilms tumors from other malignancies histologically mimicking these primitive tumors. Clinically, we recommend that glypican 3 be used as part of a panel of markers in subtyping testicular germ cell tumors.
dcterms:title
Discovery and Diagnostic Value of a Novel Oncofetal Protein: Glypican 3 Discovery and Diagnostic Value of a Novel Oncofetal Protein: Glypican 3
skos:prefLabel
Discovery and Diagnostic Value of a Novel Oncofetal Protein: Glypican 3 Discovery and Diagnostic Value of a Novel Oncofetal Protein: Glypican 3
skos:notation
RIV/00216208:11140/14:10284094!RIV15-MSM-11140___
n3:aktivita
n7:I
n3:aktivity
I
n3:cisloPeriodika
6
n3:dodaniDat
n5:2015
n3:domaciTvurceVysledku
n18:9342710
n3:druhVysledku
n8:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
11676
n3:idVysledku
RIV/00216208:11140/14:10284094
n3:jazykVysledku
n19:eng
n3:klicovaSlova
oncofetal protein; immunohistochemistry; testicular cancer; yolk sac tumor
n3:klicoveSlovo
n4:immunohistochemistry n4:oncofetal%20protein n4:yolk%20sac%20tumor n4:testicular%20cancer
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[FE1ED60DB1C6]
n3:nazevZdroje
Advances in Anatomic Pathology
n3:obor
n16:FP
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n5:2014
n3:svazekPeriodika
21
n3:tvurceVysledku
Hes, Ondřej Zynger, Debra L. Wang, Sean K. Yang, Ximing J.
n3:wos
000344252100007
s:issn
1072-4109
s:numberOfPages
10
n15:doi
10.1097/PAP.0000000000000043
n12:organizacniJednotka
11140