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Statements

Subject Item
n2:RIV%2F00216208%3A11140%2F14%3A10283644%21RIV15-MSM-11140___
rdf:type
n9:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1016/j.anndiagpath.2014.10.002
dcterms:description
t(6;11) renal cell carcinoma (RCC) has been recognized as a rare and mostly nonaggressive tumor (NAT). The criteria for distinguishing aggressive tumors (AT) from NATs are not well established. A total of 6 cases were selected for the study. Five cases of t(6;11) RCCs behaved nonaggressively, and 1 was carcinoma with aggressive behavior. The tumors were analyzed morphologically using immunohistochemistry and by molecular-genetic methods. The specimen of aggressive t(6;11) RCC was from a 77-year-old woman who died of the disease 2.5 months after diagnosis. The specimens of nonaggressive t(6;11) RCCs were from 3 women and 2 men whose ages range between 15 and 54 years. Follow-up was available in all cases (2.5 months-8 years). The tumor size ranged from 3 to 14 cm in nonaggressive t(6:11) RCC. In the aggressive carcinoma, the tumor size was 12 cm. All tumors (6/6) were well circumscribed. Aggressive t(6;11) RCC was widely necrotic. Six (100%) of 6 all tumors displayed a solid/alveolar architecture with occasional tubules and pseudorosettes. Pseudopapillary formations lined by bizarre polymorphic cells were found focally in the aggressive t(6;11) RCC case. Mitoses, though rare, were found as well. All cases (AT and NAT) were positive for HMB-45, Melan-A, Cathepsin K, and cytokeratins. CD117 positivity was seen in 4 of 5 NATs, as well as in the primary and metastatic lesions of the AT. mTOR was positive in 2 of 5 NATs and vimentin in 4 of 5 NATs. Vimentin was negative in the primary lesion of the AT, as well as in the metastasis found in the adrenal gland. Translocation t(6;11)(Alpha-TFEB) or TFEB break was detected in 4 of 5 NATs and in the AT case. t(6;11) renal cell carcinoma (RCC) has been recognized as a rare and mostly nonaggressive tumor (NAT). The criteria for distinguishing aggressive tumors (AT) from NATs are not well established. A total of 6 cases were selected for the study. Five cases of t(6;11) RCCs behaved nonaggressively, and 1 was carcinoma with aggressive behavior. The tumors were analyzed morphologically using immunohistochemistry and by molecular-genetic methods. The specimen of aggressive t(6;11) RCC was from a 77-year-old woman who died of the disease 2.5 months after diagnosis. The specimens of nonaggressive t(6;11) RCCs were from 3 women and 2 men whose ages range between 15 and 54 years. Follow-up was available in all cases (2.5 months-8 years). The tumor size ranged from 3 to 14 cm in nonaggressive t(6:11) RCC. In the aggressive carcinoma, the tumor size was 12 cm. All tumors (6/6) were well circumscribed. Aggressive t(6;11) RCC was widely necrotic. Six (100%) of 6 all tumors displayed a solid/alveolar architecture with occasional tubules and pseudorosettes. Pseudopapillary formations lined by bizarre polymorphic cells were found focally in the aggressive t(6;11) RCC case. Mitoses, though rare, were found as well. All cases (AT and NAT) were positive for HMB-45, Melan-A, Cathepsin K, and cytokeratins. CD117 positivity was seen in 4 of 5 NATs, as well as in the primary and metastatic lesions of the AT. mTOR was positive in 2 of 5 NATs and vimentin in 4 of 5 NATs. Vimentin was negative in the primary lesion of the AT, as well as in the metastasis found in the adrenal gland. Translocation t(6;11)(Alpha-TFEB) or TFEB break was detected in 4 of 5 NATs and in the AT case.
dcterms:title
Aggressive and nonaggressive translocation t(6;11) renal cell carcinoma: comparative study of 6 cases and review of the literature Aggressive and nonaggressive translocation t(6;11) renal cell carcinoma: comparative study of 6 cases and review of the literature
skos:prefLabel
Aggressive and nonaggressive translocation t(6;11) renal cell carcinoma: comparative study of 6 cases and review of the literature Aggressive and nonaggressive translocation t(6;11) renal cell carcinoma: comparative study of 6 cases and review of the literature
skos:notation
RIV/00216208:11140/14:10283644!RIV15-MSM-11140___
n3:aktivita
n14:P n14:I
n3:aktivity
I, P(ED2.1.00/03.0076)
n3:cisloPeriodika
6
n3:dodaniDat
n4:2015
n3:domaciTvurceVysledku
n6:4161572 n6:3182975 n6:9342710 n6:7880898 n6:3040631 n6:7211139 n6:1024159 n6:9711783 n6:7671997 n6:8946965 n6:7629990 n6:2975491
n3:druhVysledku
n11:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
1862
n3:idVysledku
RIV/00216208:11140/14:10283644
n3:jazykVysledku
n19:eng
n3:klicovaSlova
Molecular biology; Immunohistochemistiy; Nonaggressive; Aggressive; Translocation renal cell carcinoma t(6:11); Kidney
n3:klicoveSlovo
n12:Aggressive n12:Translocation%20renal%20cell%20carcinoma%20t%286%3A11%29 n12:Nonaggressive n12:Molecular%20biology n12:Immunohistochemistiy n12:Kidney
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[31687AF09564]
n3:nazevZdroje
Annals of Diagnostic Pathology
n3:obor
n17:FP
n3:pocetDomacichTvurcuVysledku
12
n3:pocetTvurcuVysledku
19
n3:projekt
n15:ED2.1.00%2F03.0076
n3:rokUplatneniVysledku
n4:2014
n3:svazekPeriodika
18
n3:tvurceVysledku
Rotterova, Pavla Spagnolo, Dominic Kokošková, Bohuslava Vaněček, Tomáš Kalusová, Kristýna Martínek, Petr Djuricic, Slavisa Veselá, Pavla Vranic, Semir Hes, Ondřej Pecková, Květoslava Pivovarčíková, Kristýna Hora, Milan Dubová, Magdaléna Daum, Ondřej Brunelli, Matteo Michal, Michal Bauleth, Kevin Kuroda, Naoto
n3:wos
000345196100007
s:issn
1092-9134
s:numberOfPages
7
n20:doi
10.1016/j.anndiagpath.2014.10.002
n16:organizacniJednotka
11140