This HTML5 document contains 55 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n10http://localhost/temp/predkladatel/
n15http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n11http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
rdfshttp://www.w3.org/2000/01/rdf-schema#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n17http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n5http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n8http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n16http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n18http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n14http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216208%3A11140%2F14%3A10283638%21RIV15-MSM-11140___/
n12http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n6http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216208%3A11140%2F14%3A10283638%21RIV15-MSM-11140___
rdf:type
skos:Concept n11:Vysledek
rdfs:seeAlso
http://www.karger.com/Article/Pdf/367967
dcterms:description
Herein, we report the case of a 12-year-old female who noted the recent onset of an oval, circumscribed, 10-cm papillomatous plaque affecting the thigh and vulva that showed histologic signs of lymphedema without evidence of secondary lymphedema. The sequencing of genes associated with a delayed onset of lymphedema or epidermal nevi (EN) - GATA2 and GJC2 , and HRAS and KRAS , respectively - showed wild-type alleles. Polymerase chain reaction for human papillomavirus (HPV) DNA demonstrated infections with 15 HPV genotypes. Evidence of productive HPV infection, HPV capsid expression, and cytopathic changes was detected. At the 6-month follow-up, no evidence of recurrence was found after complete excision. The analysis of a consecutive series of 91 EN excision specimens revealed that 76% exhibited histologic evidence of lymphostasis. Notably, multiple acrochordon-like EN, which most closely resembled this case, showed similar signs of localized lymphedema. The late onset and evidence of lymphedema favors the diagnosis of congenital unisegmental lymphedema. However, the clinical findings and epidermal changes point to the diagnosis of EN. Moreover, localized verrucosis also accurately describes this patient's cutaneous findings. Based on the above evidence, we postulate that an abnormal development of lymphatics may play a primary role in the pathogenesis of some types of EN and facilitate productive HPV infection. Herein, we report the case of a 12-year-old female who noted the recent onset of an oval, circumscribed, 10-cm papillomatous plaque affecting the thigh and vulva that showed histologic signs of lymphedema without evidence of secondary lymphedema. The sequencing of genes associated with a delayed onset of lymphedema or epidermal nevi (EN) - GATA2 and GJC2 , and HRAS and KRAS , respectively - showed wild-type alleles. Polymerase chain reaction for human papillomavirus (HPV) DNA demonstrated infections with 15 HPV genotypes. Evidence of productive HPV infection, HPV capsid expression, and cytopathic changes was detected. At the 6-month follow-up, no evidence of recurrence was found after complete excision. The analysis of a consecutive series of 91 EN excision specimens revealed that 76% exhibited histologic evidence of lymphostasis. Notably, multiple acrochordon-like EN, which most closely resembled this case, showed similar signs of localized lymphedema. The late onset and evidence of lymphedema favors the diagnosis of congenital unisegmental lymphedema. However, the clinical findings and epidermal changes point to the diagnosis of EN. Moreover, localized verrucosis also accurately describes this patient's cutaneous findings. Based on the above evidence, we postulate that an abnormal development of lymphatics may play a primary role in the pathogenesis of some types of EN and facilitate productive HPV infection.
dcterms:title
Adolescent onset of localized papillomatosis, lymphedema, and multiple Beta-papillomavirus infection: epidermal nevus, segmental lymphedema praecox, or verrucosis? A case report and case series of epidermal nevi Adolescent onset of localized papillomatosis, lymphedema, and multiple Beta-papillomavirus infection: epidermal nevus, segmental lymphedema praecox, or verrucosis? A case report and case series of epidermal nevi
skos:prefLabel
Adolescent onset of localized papillomatosis, lymphedema, and multiple Beta-papillomavirus infection: epidermal nevus, segmental lymphedema praecox, or verrucosis? A case report and case series of epidermal nevi Adolescent onset of localized papillomatosis, lymphedema, and multiple Beta-papillomavirus infection: epidermal nevus, segmental lymphedema praecox, or verrucosis? A case report and case series of epidermal nevi
skos:notation
RIV/00216208:11140/14:10283638!RIV15-MSM-11140___
n3:aktivita
n18:I
n3:aktivity
I
n3:cisloPeriodika
2
n3:dodaniDat
n6:2015
n3:domaciTvurceVysledku
n15:5892805
n3:druhVysledku
n4:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
1671
n3:idVysledku
RIV/00216208:11140/14:10283638
n3:jazykVysledku
n16:eng
n3:klicovaSlova
congenital lymphedema; Kras; HRAS; GJC2; GATA2; Blaschko's lines; elephantiasis; lymfphedema; human papillomavirus; epidermal nevus
n3:klicoveSlovo
n5:human%20papillomavirus n5:elephantiasis n5:Kras n5:congenital%20lymphedema n5:GJC2 n5:lymfphedema n5:Blaschko%27s%20lines n5:HRAS n5:GATA2 n5:epidermal%20nevus
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[F5966BE49550]
n3:nazevZdroje
Dermatopathology
n3:obor
n12:FP
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
11
n3:rokUplatneniVysledku
n6:2014
n3:svazekPeriodika
1
n3:tvurceVysledku
Carlson, J. Andrew Ray, Kathy Tyring, Stephen Šedivcová, Monika Rand, Janne Agag, Richard Stehlík, Jan Kadam, Pooja Kazakov, Dmitry Hill, Jarome Rady, Peter
s:issn
2296-3529
s:numberOfPages
15
n17:doi
10.1159/000367967
n10:organizacniJednotka
11140