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Statements

Subject Item
n2:RIV%2F00216208%3A11140%2F14%3A10282578%21RIV15-MSM-11140___
rdf:type
n6:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1007/s00428-014-1600-z
dcterms:description
We report nine patients (seven males and two females, median age 64 years (range 51-79 years)) with a renal cell carcinoma, each of which contained a significant component of neoplastic epithelial cells with a striking microvacuolated (hibernoma-like) cytoplasmic appearance. Tumor sizes ranged from 1.5 to 8.0 cm (mean 4.2 cm, median 4.3 cm). The basic architecture of the tumors was solid-alveolar in two cases (classified as renal cell carcinoma-not otherwise specified (NOS)) and papillary in seven cases (classified as papillary renal cell carcinoma NOS). The nuclear grade according to the Fuhrman grading system was three in all cases. By immunohistochemistry, the cells with microvacuolated cytopasm and significantly expressed adipophilin and anti-mitochondrial antigen in a similar cytoplasmic pattern. On ultrastructural examination, the cytoplasm of the neoplastic epithelial cells was packed with distended mitochondria, most of which displayed lamellated cristae. Numerous microvesicles were dispersed between the mitochondria. No mutations in the succinate dehydrogenase B gene were identified. Based on our findings, we propose that the mechanism behind this phenomenon is an abnormal intracellular processing of lipids. No aggressive behavior was observed in six out of nine patients with available follow-up information. We report nine patients (seven males and two females, median age 64 years (range 51-79 years)) with a renal cell carcinoma, each of which contained a significant component of neoplastic epithelial cells with a striking microvacuolated (hibernoma-like) cytoplasmic appearance. Tumor sizes ranged from 1.5 to 8.0 cm (mean 4.2 cm, median 4.3 cm). The basic architecture of the tumors was solid-alveolar in two cases (classified as renal cell carcinoma-not otherwise specified (NOS)) and papillary in seven cases (classified as papillary renal cell carcinoma NOS). The nuclear grade according to the Fuhrman grading system was three in all cases. By immunohistochemistry, the cells with microvacuolated cytopasm and significantly expressed adipophilin and anti-mitochondrial antigen in a similar cytoplasmic pattern. On ultrastructural examination, the cytoplasm of the neoplastic epithelial cells was packed with distended mitochondria, most of which displayed lamellated cristae. Numerous microvesicles were dispersed between the mitochondria. No mutations in the succinate dehydrogenase B gene were identified. Based on our findings, we propose that the mechanism behind this phenomenon is an abnormal intracellular processing of lipids. No aggressive behavior was observed in six out of nine patients with available follow-up information.
dcterms:title
Foamy cell (hibernoma-like) change is a rare histopathological feature in renal cell carcinoma Foamy cell (hibernoma-like) change is a rare histopathological feature in renal cell carcinoma
skos:prefLabel
Foamy cell (hibernoma-like) change is a rare histopathological feature in renal cell carcinoma Foamy cell (hibernoma-like) change is a rare histopathological feature in renal cell carcinoma
skos:notation
RIV/00216208:11140/14:10282578!RIV15-MSM-11140___
n3:aktivita
n17:I n17:P
n3:aktivity
I, P(ED2.1.00/03.0076)
n3:cisloPeriodika
2
n3:dodaniDat
n9:2015
n3:domaciTvurceVysledku
n8:7629990 n8:9342710 n8:9711783 Švajdler, Marián n8:3182975 n8:1024159 n8:2096854 n8:7880898 n8:2975491
n3:druhVysledku
n18:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
17131
n3:idVysledku
RIV/00216208:11140/14:10282578
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Unclassified renal cell carcinoma; Clear cell renal cell carcinoma; Papillary renal cell carcinoma; Lipoma-like; Hibernoma-like; Renal cell carcinoma; Kidney
n3:klicoveSlovo
n14:Papillary%20renal%20cell%20carcinoma n14:Hibernoma-like n14:Unclassified%20renal%20cell%20carcinoma n14:Lipoma-like n14:Clear%20cell%20renal%20cell%20carcinoma n14:Renal%20cell%20carcinoma n14:Kidney
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[68C1906D6642]
n3:nazevZdroje
Virchows Archiv : an international journal of pathology
n3:obor
n20:FP
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
19
n3:projekt
n11:ED2.1.00%2F03.0076
n3:rokUplatneniVysledku
n9:2014
n3:svazekPeriodika
465
n3:tvurceVysledku
Tichý, Tomáš Branžovský, Jindřich Petersson, Fredrik Pivovarčíková, Kristýna Michal, Michal Švajdler, Marián Hes, Ondřej Martínek, Petr Bulimbasic, Stela Pecková, Květoslava Sperga, Maris Rotterova, Pavla Bauleth, Kevin Nagy, Vincent Kokošková, Bohuslava Simpson, Roderick Kuroda, Naoto Hora, Milan Martinčok, Dušan
n3:wos
000339950400011
s:issn
0945-6317
s:numberOfPages
10
n16:doi
10.1007/s00428-014-1600-z
n15:organizacniJednotka
11140