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Statements

Subject Item
n2:RIV%2F00216208%3A11140%2F14%3A10282508%21RIV15-MSM-11140___
rdf:type
n13:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1016/j.anndiagpath.2014.08.004
dcterms:description
Renal cell carcinoma (RCC) with leiomyomatous stroma (RCCLS) is a recently recognized entity with indolent biological behavior. The diagnostic implication of absence/presence of VHL gene mutation, VHL hypermethylation, or/and loss of heterozygosity of chromosome 3p (LOH 3p) is widely discussed. Criteria for establishing a diagnosis of RCCLS are still lacking. Fifteen RCCLSs were retrieved from our registry. The cases were studied with consideration to the morphology, immunohistochemistry, and molecular genetics. All cases were composed of low-grade epithelial cells with clear cytoplasm arranged in nests intermingled with abundant leiomyomatous stroma. Age range of the patients was 33 to 78 years. The tumor size ranged from 1.5 to 11 cm. Six of the patients were males, and 9, females. Of the 15 tumors sent for molecular genetic testing, only 12 cases were analyzable. All cases were analyzable immunohistochemically. Of 12 of these cases, 5 showed complete absence of VHL gene mutation, VHL hypermethylation, and LOH 3p. Of theses cases,3 were positive for cytokeratin 7 (CK 7). All of the 5 cases were positive for carbonic anhydrase 9, vimentin, and CD10. The remaining 7 of 12 genetically analyzable cases were found to have had VHL hypermethylation, LOH 3p, VHL gene mutation, or a combination of the former 2 characteristics. These 7 cases were positive for vimentin. Variable reactivity was found for CK 7, carbonic anhydrase 9, alpha-methylacyl-CoA racemase, and CD10. In 1 of these 7 cases, gains on chromosomes 7 and 17 as well as hypermethylation of VHL gene were found. This case was considered as clear cell RCC with aberrant status of chromosomes 7 and 17. Conclusions: (1) Leiomyomatous stroma is not specific for the so called RCCLS. It can be seen also in otherwise typical clear cell RCCs. (2) There are no characteristic morphological/immunohistochemical features unique for %22RCCLS.%22 Renal cell carcinoma (RCC) with leiomyomatous stroma (RCCLS) is a recently recognized entity with indolent biological behavior. The diagnostic implication of absence/presence of VHL gene mutation, VHL hypermethylation, or/and loss of heterozygosity of chromosome 3p (LOH 3p) is widely discussed. Criteria for establishing a diagnosis of RCCLS are still lacking. Fifteen RCCLSs were retrieved from our registry. The cases were studied with consideration to the morphology, immunohistochemistry, and molecular genetics. All cases were composed of low-grade epithelial cells with clear cytoplasm arranged in nests intermingled with abundant leiomyomatous stroma. Age range of the patients was 33 to 78 years. The tumor size ranged from 1.5 to 11 cm. Six of the patients were males, and 9, females. Of the 15 tumors sent for molecular genetic testing, only 12 cases were analyzable. All cases were analyzable immunohistochemically. Of 12 of these cases, 5 showed complete absence of VHL gene mutation, VHL hypermethylation, and LOH 3p. Of theses cases,3 were positive for cytokeratin 7 (CK 7). All of the 5 cases were positive for carbonic anhydrase 9, vimentin, and CD10. The remaining 7 of 12 genetically analyzable cases were found to have had VHL hypermethylation, LOH 3p, VHL gene mutation, or a combination of the former 2 characteristics. These 7 cases were positive for vimentin. Variable reactivity was found for CK 7, carbonic anhydrase 9, alpha-methylacyl-CoA racemase, and CD10. In 1 of these 7 cases, gains on chromosomes 7 and 17 as well as hypermethylation of VHL gene were found. This case was considered as clear cell RCC with aberrant status of chromosomes 7 and 17. Conclusions: (1) Leiomyomatous stroma is not specific for the so called RCCLS. It can be seen also in otherwise typical clear cell RCCs. (2) There are no characteristic morphological/immunohistochemical features unique for %22RCCLS.%22
dcterms:title
Renal cell carcinoma with leiomyomatous stroma-further immunohistochemical and molecular genetic characteristics of unusual entity Renal cell carcinoma with leiomyomatous stroma-further immunohistochemical and molecular genetic characteristics of unusual entity
skos:prefLabel
Renal cell carcinoma with leiomyomatous stroma-further immunohistochemical and molecular genetic characteristics of unusual entity Renal cell carcinoma with leiomyomatous stroma-further immunohistochemical and molecular genetic characteristics of unusual entity
skos:notation
RIV/00216208:11140/14:10282508!RIV15-MSM-11140___
n3:aktivita
n19:P n19:I
n3:aktivity
I, P(ED2.1.00/03.0076)
n3:cisloPeriodika
5
n3:dodaniDat
n8:2015
n3:domaciTvurceVysledku
n7:3040631 n7:4161572 Bauleth, Pele Kevin D'almeida n7:1024159 n7:2096854 n7:2975491 n7:7880898 n7:8946965 n7:9342710 n7:7629990 n7:3182975
n3:druhVysledku
n17:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
42169
n3:idVysledku
RIV/00216208:11140/14:10282508
n3:jazykVysledku
n5:eng
n3:klicovaSlova
Clear cell carcinoma; LOH 3p; VHL gene mutation; Leiomyomatous stroma; Renal cell carcinoma; Kidney
n3:klicoveSlovo
n12:VHL%20gene%20mutation n12:Kidney n12:Renal%20cell%20carcinoma n12:LOH%203p n12:Leiomyomatous%20stroma n12:Clear%20cell%20carcinoma
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[BC78EC09C1A3]
n3:nazevZdroje
Annals of Diagnostic Pathology
n3:obor
n20:FP
n3:pocetDomacichTvurcuVysledku
11
n3:pocetTvurcuVysledku
16
n3:projekt
n15:ED2.1.00%2F03.0076
n3:rokUplatneniVysledku
n8:2014
n3:svazekPeriodika
18
n3:tvurceVysledku
Perez Montiel, Delia Pivovarčíková, Kristýna Dubová, Magdaléna Veselá, Pavla Rotterova, Pavla Kokošková, Bohuslava Sperga, Maris Michal, Michal Hora, Milan Pecková, Květoslava Grossmann, Petr Branžovský, Jindřich Bulimbasic, Stela Hes, Ondřej Bauleth, Pele Kevin D'almeida Daum, Ondřej
n3:wos
000342121600007
s:issn
1092-9134
s:numberOfPages
6
n18:doi
10.1016/j.anndiagpath.2014.08.004
n6:organizacniJednotka
11140