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Statements

Subject Item
n2:RIV%2F00216208%3A11140%2F14%3A10271673%21RIV15-MSM-11140___
rdf:type
n17:Vysledek skos:Concept
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0166432814003970
dcterms:description
Mutant mice are commonly used models of hereditary diseases. Nevertheless, these mice have phenotypic traits of the original strain, which could interfere with the manifestation of the mutation of interest. Lurcher mice represent a model of olivocerebellar degeneration, which is caused by the Grid2(Lc) mutation. Lurchers show ataxia and various cognitive and behavioral abnormalities. The most commonly used strains of Lurcher mice are B6CBA and C3H, but there is no information about the role of genetic background on the Grid2(Lc) manifestation. The aim of this work was to compare spatial navigation in the Morris water maze, spontaneous activity in the open field and motor skills on the horizontal wire, slanted ladder and rotarod in B6CBA and C3H Lurcher mutant and wild type mice. The study showed impaired motor skills and water maze performance in both strains of Lurcher mice. Both C3H Lurcher and C3H wild type mice had poorer performances in the water maze task than their B6CBA counterparts. In the open field test, C3H mice showed higher activity and lower thigmotaxis. The study showed that genetic backgrounds can modify manifestations of the Lurcher mutation. In this case, B6CBA Lurcher mice models probably have more validity when studying the behavioral aspects of cerebellar degeneration than C3H Lurcher mice, since they do not combine abnormalities related to the Grid2(Lc) mutation with strain-specific problems. Mutant mice are commonly used models of hereditary diseases. Nevertheless, these mice have phenotypic traits of the original strain, which could interfere with the manifestation of the mutation of interest. Lurcher mice represent a model of olivocerebellar degeneration, which is caused by the Grid2(Lc) mutation. Lurchers show ataxia and various cognitive and behavioral abnormalities. The most commonly used strains of Lurcher mice are B6CBA and C3H, but there is no information about the role of genetic background on the Grid2(Lc) manifestation. The aim of this work was to compare spatial navigation in the Morris water maze, spontaneous activity in the open field and motor skills on the horizontal wire, slanted ladder and rotarod in B6CBA and C3H Lurcher mutant and wild type mice. The study showed impaired motor skills and water maze performance in both strains of Lurcher mice. Both C3H Lurcher and C3H wild type mice had poorer performances in the water maze task than their B6CBA counterparts. In the open field test, C3H mice showed higher activity and lower thigmotaxis. The study showed that genetic backgrounds can modify manifestations of the Lurcher mutation. In this case, B6CBA Lurcher mice models probably have more validity when studying the behavioral aspects of cerebellar degeneration than C3H Lurcher mice, since they do not combine abnormalities related to the Grid2(Lc) mutation with strain-specific problems.
dcterms:title
The effect of genetic background on behavioral manifestation of Grid2(Lc) mutation The effect of genetic background on behavioral manifestation of Grid2(Lc) mutation
skos:prefLabel
The effect of genetic background on behavioral manifestation of Grid2(Lc) mutation The effect of genetic background on behavioral manifestation of Grid2(Lc) mutation
skos:notation
RIV/00216208:11140/14:10271673!RIV15-MSM-11140___
n3:aktivita
n18:S n18:P n18:I
n3:aktivity
I, P(ED2.1.00/03.0076), P(LD12056), P(LD12057), S
n3:cisloPeriodika
September
n3:dodaniDat
n13:2015
n3:domaciTvurceVysledku
n11:6646948 n11:6134211 n11:7354002 n11:5711533
n3:druhVysledku
n20:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
13297
n3:idVysledku
RIV/00216208:11140/14:10271673
n3:jazykVysledku
n4:eng
n3:klicovaSlova
Spatial orientation; Lurcher mice; Genetic background; Cerebellar degeneration; Ataxia
n3:klicoveSlovo
n8:Genetic%20background n8:Cerebellar%20degeneration n8:Lurcher%20mice n8:Spatial%20orientation n8:Ataxia
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[9EB6729E7F2D]
n3:nazevZdroje
Behavioural Brain Research
n3:obor
n5:FH
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n14:LD12056 n14:LD12057 n14:ED2.1.00%2F03.0076
n3:rokUplatneniVysledku
n13:2014
n3:svazekPeriodika
271
n3:tvurceVysledku
Korelusová, Ivana Cendelín, Jan Tůma, Jan Vožeh, František
n3:wos
000340323000030
s:issn
0166-4328
s:numberOfPages
10
n19:doi
10.1016/j.bbr.2014.06.023
n9:organizacniJednotka
11140