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Statements

Subject Item
n2:RIV%2F00216208%3A11140%2F14%3A10218505%21RIV15-MSM-11140___
rdf:type
skos:Concept n19:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1038/hr.2013.113
dcterms:description
Aortic stiffness is strongly related to age and mean arterial pressure (MAP). In the present analysis, we investigated whether antihypertensive treatment modulates the association of the aortic pulse wave velocity (PWV) with age and with MAP in the general population. In the Czech post-MONICA cross-sectional study, we measured the PWV in 735 subjects (mean age 61.2 +/- 7.8 years, 54.1% women, 44.3% on antihypertensive medication). We used a linear regression model to assess the effect of treatment on the PWV. The independent covariates in our analysis included sex, age, MAP, heart rate, body mass index, plasma glucose, low-density lipoprotein cholesterol, smoking and observer. The patients receiving treatment were older (64.1 +/- 6.7 vs. 58.9 +/- 7.8 years), had higher systolic blood pressure (135.9 +/- 16.2 vs. 130.1 +/- 16.5 mm Hg) and had higher pulse wave velocity (9.1 +/- 2.2 vs. 8.2 +/- 2.1 m s(-1); P for all <0.0001) than untreated subjects. After adjustment for MAP, the use of treatment modified the association between age and the PWV (regression equations, treated patients 9.68-0.009 x age vs. untreated subjects 6.98+0.020 x age, difference of regression slopes, F = 11.2; P = 0.0009). In analyses adjusted for age, treatment was associated with a smaller increase of the PWV with MAP (treated patients 9.63-0.006 x MAP vs. untreated subjects 7.18+0.010 x MAP, F = 10.70; P = 0.0001). These results were driven primarily by subjects whose blood pressure was below 140/90 mm Hg. In the cross-sectional analysis from a random sample of the general population, antihypertensive treatment was associated with a less steep increase in the PWV with age and the mean arterial pressure. Further longitudinal studies are needed to confirm this finding. Aortic stiffness is strongly related to age and mean arterial pressure (MAP). In the present analysis, we investigated whether antihypertensive treatment modulates the association of the aortic pulse wave velocity (PWV) with age and with MAP in the general population. In the Czech post-MONICA cross-sectional study, we measured the PWV in 735 subjects (mean age 61.2 +/- 7.8 years, 54.1% women, 44.3% on antihypertensive medication). We used a linear regression model to assess the effect of treatment on the PWV. The independent covariates in our analysis included sex, age, MAP, heart rate, body mass index, plasma glucose, low-density lipoprotein cholesterol, smoking and observer. The patients receiving treatment were older (64.1 +/- 6.7 vs. 58.9 +/- 7.8 years), had higher systolic blood pressure (135.9 +/- 16.2 vs. 130.1 +/- 16.5 mm Hg) and had higher pulse wave velocity (9.1 +/- 2.2 vs. 8.2 +/- 2.1 m s(-1); P for all <0.0001) than untreated subjects. After adjustment for MAP, the use of treatment modified the association between age and the PWV (regression equations, treated patients 9.68-0.009 x age vs. untreated subjects 6.98+0.020 x age, difference of regression slopes, F = 11.2; P = 0.0009). In analyses adjusted for age, treatment was associated with a smaller increase of the PWV with MAP (treated patients 9.63-0.006 x MAP vs. untreated subjects 7.18+0.010 x MAP, F = 10.70; P = 0.0001). These results were driven primarily by subjects whose blood pressure was below 140/90 mm Hg. In the cross-sectional analysis from a random sample of the general population, antihypertensive treatment was associated with a less steep increase in the PWV with age and the mean arterial pressure. Further longitudinal studies are needed to confirm this finding.
dcterms:title
Positive effects of antihypertensive treatment on aortic stiffness in the general population Positive effects of antihypertensive treatment on aortic stiffness in the general population
skos:prefLabel
Positive effects of antihypertensive treatment on aortic stiffness in the general population Positive effects of antihypertensive treatment on aortic stiffness in the general population
skos:notation
RIV/00216208:11140/14:10218505!RIV15-MSM-11140___
n3:aktivita
n10:P n10:I n10:V
n3:aktivity
I, P(ED2.1.00/03.0076), V
n3:cisloPeriodika
1
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
n4:3820084 n4:4056523 n4:7942052
n3:druhVysledku
n9:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
37712
n3:idVysledku
RIV/00216208:11140/14:10218505
n3:jazykVysledku
n7:eng
n3:klicovaSlova
pulse wave velocity; epidemiology; arterial stiffness; antihypertensive treatment
n3:klicoveSlovo
n8:arterial%20stiffness n8:epidemiology n8:antihypertensive%20treatment n8:pulse%20wave%20velocity
n3:kodStatuVydavatele
JP - Japonsko
n3:kontrolniKodProRIV
[E938A1B3135B]
n3:nazevZdroje
Hypertension Research
n3:obor
n16:FE
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
5
n3:projekt
n12:ED2.1.00%2F03.0076
n3:rokUplatneniVysledku
n14:2014
n3:svazekPeriodika
37
n3:tvurceVysledku
Mlíková Seidlerová, Jitka Mayer, Otto Cífková, Renata Wohlfahrt, Peter Filipovský, Jan
n3:wos
000329317600011
s:issn
0916-9636
s:numberOfPages
5
n11:doi
10.1038/hr.2013.113
n18:organizacniJednotka
11140