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Statements

Subject Item
n2:RIV%2F00216208%3A11140%2F14%3A10192707%21RIV15-MSM-11140___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Organ transplant recipients (OTR) are at high risk for cutaneous squamous cell carcinomas (SCC). We aimed to define clinically meaningful patient-reported warning signals predicting the presence of invasive SCC. Patient-reported signs and symptoms of 812 consecutively biopsied skin lesions from 410 OTR were determinde by questionnaire and physical examination and related to the subsequent biopsy-proven diagnoses. Receiver-operating characteristic (ROC) curve analyses were used as a measure of distinction between the predictive values of patient-reported warning signals and the occurrence of SCC. Pain was an independent predictive patient-reported warning signal for a biopsy-proven invasive SCC. The odds ratio from the fully adjusted model predicting SCC was 4.4 (95% confidence interval: 2.4-8.2). Higher scores on the visual analog scale (VAS) for pain were associated with a greater likelihood for the presence of SCC compared to none or mild pain. The for scores on the VAS from 1 to 3, 4 to 6 and 7 to 10 were 4.9 (2.2-10-5), 2.3 (0,96-5.5) and 16.5 (3.6-75.8), respectively. Pain is the most powerful patient-reported warning signal for invasive cutaneous SCC in OTR. Empowerment of patients by education could accelerate diagnosis and treatment of cutaneous SCC. Organ transplant recipients (OTR) are at high risk for cutaneous squamous cell carcinomas (SCC). We aimed to define clinically meaningful patient-reported warning signals predicting the presence of invasive SCC. Patient-reported signs and symptoms of 812 consecutively biopsied skin lesions from 410 OTR were determinde by questionnaire and physical examination and related to the subsequent biopsy-proven diagnoses. Receiver-operating characteristic (ROC) curve analyses were used as a measure of distinction between the predictive values of patient-reported warning signals and the occurrence of SCC. Pain was an independent predictive patient-reported warning signal for a biopsy-proven invasive SCC. The odds ratio from the fully adjusted model predicting SCC was 4.4 (95% confidence interval: 2.4-8.2). Higher scores on the visual analog scale (VAS) for pain were associated with a greater likelihood for the presence of SCC compared to none or mild pain. The for scores on the VAS from 1 to 3, 4 to 6 and 7 to 10 were 4.9 (2.2-10-5), 2.3 (0,96-5.5) and 16.5 (3.6-75.8), respectively. Pain is the most powerful patient-reported warning signal for invasive cutaneous SCC in OTR. Empowerment of patients by education could accelerate diagnosis and treatment of cutaneous SCC.
dcterms:title
Pain Identifies Squamous Cell Carcinoma in Organ Transplant Recipients: The SCOPE-ITSCC PAIN Study Pain Identifies Squamous Cell Carcinoma in Organ Transplant Recipients: The SCOPE-ITSCC PAIN Study
skos:prefLabel
Pain Identifies Squamous Cell Carcinoma in Organ Transplant Recipients: The SCOPE-ITSCC PAIN Study Pain Identifies Squamous Cell Carcinoma in Organ Transplant Recipients: The SCOPE-ITSCC PAIN Study
skos:notation
RIV/00216208:11140/14:10192707!RIV15-MSM-11140___
n3:aktivita
n8:I
n3:aktivity
I
n3:cisloPeriodika
3
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
n11:3424944 n11:8090629
n3:druhVysledku
n12:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
35601
n3:idVysledku
RIV/00216208:11140/14:10192707
n3:jazykVysledku
n10:eng
n3:klicovaSlova
squamous cell carcinoma; pain; Adverse affect
n3:klicoveSlovo
n13:pain n13:squamous%20cell%20carcinoma n13:Adverse%20affect
n3:kodStatuVydavatele
DK - Dánské království
n3:kontrolniKodProRIV
[3A2C0CF4AACB]
n3:nazevZdroje
American Journal of Transplantation
n3:obor
n15:FO
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
24
n3:rokUplatneniVysledku
n14:2014
n3:svazekPeriodika
14
n3:tvurceVysledku
Mosel, D. D. Cetkovská, Petra Gülec, A. T. Jahn, K. Imko-Walczuk, B. Plasmeijer, E. I. Hofbauer, G. F. L. Conzett, K. B. Seckin, D. Wisgerhof, H. C. Pokorney, M. S. Mitchell, L. Piaserico, S. Feldmeyer, L. Geusau, A. Genders, R. E. Bavinck, J. N. B. Olasz, E. B. Harwood, C. A. Serra, A. L. Proby, C. M. Fortina, A. B. Gerritsen, M. J. P. Říčař, Jan
n3:wos
000331783200022
s:issn
1600-6135
s:numberOfPages
9
n17:doi
10.1111/ajt.12587
n16:organizacniJednotka
11140