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Statements

Subject Item
n2:RIV%2F00216208%3A11140%2F13%3A10159255%21RIV14-MSM-11140___
rdf:type
n9:Vysledek skos:Concept
rdfs:seeAlso
http://fb.cuni.cz/file/5701/FB2013A0028.pdf
dcterms:description
The aim of our work is to detect and identify seminal proteins that are related to female isoimmunization. In this report, we quantified serum anti-seminal IgG antibodies. Seminal proteins were analysed by twodimensional gel electrophoresis followed by immunoblotting. To identify IgG-binding proteins of interest, a proteomic approach was selected. The dominant seminal antigens were detected within the relative molecular mass ranging from 25 to 85 kDa and the isoelectric point from 5 to 7. The detected proteins were further identified as prostate-specific antigen, prostatic acid phosphatase, zinc-α-2-glycoprotein and zinc finger protein 778. Since these proteins were recognized by IgGs produced by infertile women and not by fertile women, we presume that major seminal antigens may play an important role in the pathogenesis of female immune infertility. Our study suggests the pattern of seminal proteins for further therapeutic attempts in the diagnosis of female immune infertility. The aim of our work is to detect and identify seminal proteins that are related to female isoimmunization. In this report, we quantified serum anti-seminal IgG antibodies. Seminal proteins were analysed by twodimensional gel electrophoresis followed by immunoblotting. To identify IgG-binding proteins of interest, a proteomic approach was selected. The dominant seminal antigens were detected within the relative molecular mass ranging from 25 to 85 kDa and the isoelectric point from 5 to 7. The detected proteins were further identified as prostate-specific antigen, prostatic acid phosphatase, zinc-α-2-glycoprotein and zinc finger protein 778. Since these proteins were recognized by IgGs produced by infertile women and not by fertile women, we presume that major seminal antigens may play an important role in the pathogenesis of female immune infertility. Our study suggests the pattern of seminal proteins for further therapeutic attempts in the diagnosis of female immune infertility.
dcterms:title
Immunodominant Semen Proteins II: Contribution of Seminal Proteins to Female Immune Infertility Immunodominant Semen Proteins II: Contribution of Seminal Proteins to Female Immune Infertility
skos:prefLabel
Immunodominant Semen Proteins II: Contribution of Seminal Proteins to Female Immune Infertility Immunodominant Semen Proteins II: Contribution of Seminal Proteins to Female Immune Infertility
skos:notation
RIV/00216208:11140/13:10159255!RIV14-MSM-11140___
n9:predkladatel
n10:orjk%3A11140
n3:aktivita
n15:I n15:S n15:P
n3:aktivity
I, P(IAA600110902), S
n3:cisloPeriodika
5
n3:dodaniDat
n6:2014
n3:domaciTvurceVysledku
n16:1455168
n3:druhVysledku
n17:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
78907
n3:idVysledku
RIV/00216208:11140/13:10159255
n3:jazykVysledku
n18:eng
n3:klicovaSlova
prostatic acid phosphatase; prostate-specific antigen; female immune infertility; IgG antibodies
n3:klicoveSlovo
n11:IgG%20antibodies n11:prostatic%20acid%20phosphatase n11:prostate-specific%20antigen n11:female%20immune%20infertility
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[CE4085FCC326]
n3:nazevZdroje
Folia Biologica
n3:obor
n12:FK
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:projekt
n19:IAA600110902
n3:rokUplatneniVysledku
n6:2013
n3:svazekPeriodika
59
n3:tvurceVysledku
Peltre, G. Sénéchal, H. Zídková, H. Poncet, P. Ulčová-Gallová, Zdeňka Brázdová, A. Vermachová, J.
n3:wos
000327577300004
s:issn
0015-5500
s:numberOfPages
6
n5:organizacniJednotka
11140