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Statements

Subject Item
n2:RIV%2F00216208%3A11140%2F13%3A10140200%21RIV14-MSM-11140___
rdf:type
n8:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1093/ajh/hps119
dcterms:description
BACKGROUND The double product (DP), consisting of the systolic blood pressure (SBP) multiplied by the pulse rate (PR), is an index of myocardial oxygen consumption, but its prognostic value in the general population remains unknown. METHODS We recorded health outcomes in 9,937 subjects (median age, 53.2 years; 47.3% women) randomly recruited from 11 populations and enrolled in the International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) study. We obtained the SBP, PR, and DP for these subjects as determined through 24-hour ambulatory monitoring. RESULTS Over a median period of 11.0 years, 1,388 of the 9,937 study subjects died, of whom 536 and 794, respectively, died of cardiovascular (CV) and non-CV causes, and a further 1,161, 658, 494, and 465 subjects, respectively, experienced a CV, cardiac, coronary, or cerebrovascular event. In multivariate-adjusted Cox models, not including SBP and PR, DP predicted total, CV, and non-CV mortality (standardized hazard ratio [HR], }= 1.10; P {= 0.02), and all CV, cardiac, coronary, and stroke events (HR, }= 1.21; P < 0.0001). For CV mortality (HR, 1.34 vs. 1.30; P = 0.71) and coronary events (1.28 vs. 1.21; P = 0.26), SBP and the DP were equally predictive. As compared with DP, SBP was a stronger predictor of all CV events (1.39 vs. 1.27; P = 0.002) and stroke (1.61 vs. 1.36; P < 0.0001), and a slightly stronger predictor of cardiac events (1.32 vs. 1.22; P = 0.06). In fully adjusted models, including both SBP and PR, the predictive value of DP disappeared for fatal endpoints (P }= 0.07), coronary events (P = 0.06), and stroke (P = 0.12), or DP was even inversely associated with the risk of all CV and cardiac events (both P {= 0.01). CONCLUSION In the general population, we did not observe DP to add to risk stratification over and beyond SBP and PR. BACKGROUND The double product (DP), consisting of the systolic blood pressure (SBP) multiplied by the pulse rate (PR), is an index of myocardial oxygen consumption, but its prognostic value in the general population remains unknown. METHODS We recorded health outcomes in 9,937 subjects (median age, 53.2 years; 47.3% women) randomly recruited from 11 populations and enrolled in the International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) study. We obtained the SBP, PR, and DP for these subjects as determined through 24-hour ambulatory monitoring. RESULTS Over a median period of 11.0 years, 1,388 of the 9,937 study subjects died, of whom 536 and 794, respectively, died of cardiovascular (CV) and non-CV causes, and a further 1,161, 658, 494, and 465 subjects, respectively, experienced a CV, cardiac, coronary, or cerebrovascular event. In multivariate-adjusted Cox models, not including SBP and PR, DP predicted total, CV, and non-CV mortality (standardized hazard ratio [HR], }= 1.10; P {= 0.02), and all CV, cardiac, coronary, and stroke events (HR, }= 1.21; P < 0.0001). For CV mortality (HR, 1.34 vs. 1.30; P = 0.71) and coronary events (1.28 vs. 1.21; P = 0.26), SBP and the DP were equally predictive. As compared with DP, SBP was a stronger predictor of all CV events (1.39 vs. 1.27; P = 0.002) and stroke (1.61 vs. 1.36; P < 0.0001), and a slightly stronger predictor of cardiac events (1.32 vs. 1.22; P = 0.06). In fully adjusted models, including both SBP and PR, the predictive value of DP disappeared for fatal endpoints (P }= 0.07), coronary events (P = 0.06), and stroke (P = 0.12), or DP was even inversely associated with the risk of all CV and cardiac events (both P {= 0.01). CONCLUSION In the general population, we did not observe DP to add to risk stratification over and beyond SBP and PR.
dcterms:title
Double Product Reflects the Predictive Power of Systolic Pressure in the General Population: Evidence from 9,937 Participants Double Product Reflects the Predictive Power of Systolic Pressure in the General Population: Evidence from 9,937 Participants
skos:prefLabel
Double Product Reflects the Predictive Power of Systolic Pressure in the General Population: Evidence from 9,937 Participants Double Product Reflects the Predictive Power of Systolic Pressure in the General Population: Evidence from 9,937 Participants
skos:notation
RIV/00216208:11140/13:10140200!RIV14-MSM-11140___
n8:predkladatel
n9:orjk%3A11140
n3:aktivita
n12:R
n3:aktivity
R
n3:cisloPeriodika
5
n3:dodaniDat
n14:2014
n3:domaciTvurceVysledku
n4:7942052
n3:druhVysledku
n17:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
70508
n3:idVysledku
RIV/00216208:11140/13:10140200
n3:jazykVysledku
n20:eng
n3:klicovaSlova
general population; hypertension; cardiovascular risk; systolic blood pressure; double product; blood pressure
n3:klicoveSlovo
n16:cardiovascular%20risk n16:double%20product n16:general%20population n16:systolic%20blood%20pressure n16:hypertension n16:blood%20pressure
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[DB609ECEEBC7]
n3:nazevZdroje
American Journal of Hypertension
n3:obor
n18:FA
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
28
n3:rokUplatneniVysledku
n14:2013
n3:svazekPeriodika
26
n3:tvurceVysledku
Stolarz-Skrzypek, Katarzyna Wang, Jiguang Lind, Lars Li, Yan Filipovský, Jan Nikitin, Yuri Casiglia, Edoardo Ibsen, Hans Bjorklund-Bodegard, Kristina Sandoya, Edgardo Imai, Yutaka Boggia, Jose Hansen, Tine W. Tikhonoff, Valerie Torp-Pedersen, Christian Thijs, Lutgarde Dolan, Eamon Asayama, Kei Ohkubo, Takayoshi Kawecka-Jaszcz, Kalina Liu, Yan-Ping Staessen, Jan A. Kuznetsova, Tatiana Malyutina, Sofia Jeppesen, Jorgen Schutte, Rudolph Kikuya, Masahiro O'Brien, Eoin
n3:wos
000317320300011
s:issn
0895-7061
s:numberOfPages
8
n10:doi
10.1093/ajh/hps119
n11:organizacniJednotka
11140