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Statements

Subject Item
n2:RIV%2F00216208%3A11140%2F13%3A10138981%21RIV14-MSM-11140___
rdf:type
skos:Concept n6:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.3109/08037051.2012.749578
dcterms:description
Objective. To investigate determinants of increase in aortic pulse wave velocity (PWV) in elderly subjects free from overt cardiovascular disease and not treated for arterial hypertension at baseline. Methods. The present study included 90 lecture attendees (%22Continuing Adult Education%22) who were examined at baseline and after a median follow-up of 9.5 years, including the PWV measurement using SphygmoCor. We used multiple linear regression analyses to assess predictors of PWV change. As independent covariates, we considered parameters with known effect on arterial stiffness and use of antihypertensive and lipid lowering medication. Results. At baseline, mean age was 66.9 +/- 5.1 years, and 37.8% of subjects had arterial hypertension, respectively. The PWV increased from 9.4 to 10.2 m/s; p = 0.035. While accounting for covariates, PWV was significantly and independently associated with four factors: baseline heart rate (beta = 0.074, chi(2) = 7.40; p = 0.0079), mean arterial pressure (beta = 0.070, chi(2) = 11.39; p = 0.0011), fasting glucose (beta = 0.790, chi(2) = 11.30; p = 0.0012), and use of antihypertensive medication (beta = -1.416, chi(2) = 7.95; p = 0.0060). We did not observe correlation between PWV increase and lipid or renal parameters and lipid lowering medication. Conclusions. In elderly subjects without manifest cardiovascular disease, mechanical load and glucose concentration play a major role in the aortic stiffening. Use of antihypertensive treatment was associated with smaller PWV increase. Objective. To investigate determinants of increase in aortic pulse wave velocity (PWV) in elderly subjects free from overt cardiovascular disease and not treated for arterial hypertension at baseline. Methods. The present study included 90 lecture attendees (%22Continuing Adult Education%22) who were examined at baseline and after a median follow-up of 9.5 years, including the PWV measurement using SphygmoCor. We used multiple linear regression analyses to assess predictors of PWV change. As independent covariates, we considered parameters with known effect on arterial stiffness and use of antihypertensive and lipid lowering medication. Results. At baseline, mean age was 66.9 +/- 5.1 years, and 37.8% of subjects had arterial hypertension, respectively. The PWV increased from 9.4 to 10.2 m/s; p = 0.035. While accounting for covariates, PWV was significantly and independently associated with four factors: baseline heart rate (beta = 0.074, chi(2) = 7.40; p = 0.0079), mean arterial pressure (beta = 0.070, chi(2) = 11.39; p = 0.0011), fasting glucose (beta = 0.790, chi(2) = 11.30; p = 0.0012), and use of antihypertensive medication (beta = -1.416, chi(2) = 7.95; p = 0.0060). We did not observe correlation between PWV increase and lipid or renal parameters and lipid lowering medication. Conclusions. In elderly subjects without manifest cardiovascular disease, mechanical load and glucose concentration play a major role in the aortic stiffening. Use of antihypertensive treatment was associated with smaller PWV increase.
dcterms:title
Determinants of aortic stiffening in elderly subjects: Results of a nine-year follow-up Determinants of aortic stiffening in elderly subjects: Results of a nine-year follow-up
skos:prefLabel
Determinants of aortic stiffening in elderly subjects: Results of a nine-year follow-up Determinants of aortic stiffening in elderly subjects: Results of a nine-year follow-up
skos:notation
RIV/00216208:11140/13:10138981!RIV14-MSM-11140___
n6:predkladatel
n7:orjk%3A11140
n4:aktivita
n14:I
n4:aktivity
I
n4:cisloPeriodika
3
n4:dodaniDat
n9:2014
n4:domaciTvurceVysledku
n16:6081010 n16:3820084 n16:7942052
n4:druhVysledku
n12:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n11:predkladatel
n4:idSjednocenehoVysledku
68813
n4:idVysledku
RIV/00216208:11140/13:10138981
n4:jazykVysledku
n5:eng
n4:klicovaSlova
pulse wave velocity; glucose; elderly; arterial stiffness; Antihypertensive treatment
n4:klicoveSlovo
n10:glucose n10:arterial%20stiffness n10:elderly n10:Antihypertensive%20treatment n10:pulse%20wave%20velocity
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[6C0CBCE14AB1]
n4:nazevZdroje
Blood Pressure
n4:obor
n17:FE
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
3
n4:rokUplatneniVysledku
n9:2013
n4:svazekPeriodika
22
n4:tvurceVysledku
Filipovský, Jan Dolejšová, Milena Mlíková Seidlerová, Jitka
n4:wos
000318807100008
s:issn
0803-7051
s:numberOfPages
6
n19:doi
10.3109/08037051.2012.749578
n8:organizacniJednotka
11140