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Statements

Subject Item
n2:RIV%2F00216208%3A11140%2F13%3A10138961%21RIV14-MSM-11140___
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
http://ac.els-cdn.com/S0304394013002759/1-s2.0-S0304394013002759-main.pdf?_tid=63c90cda-097b-11e3-a29c-00000aab0f01&acdnat=1376991311_bdf9283d61c8680bc2d025dc056fbd25
dcterms:description
DMSO has been many times described as harmless substance, beneficial in various diseases or pathological states, including brain injury or ischemia. Using Lurcher mutant mice suffering from genetically determined olivocerebellar degeneration and normal wild type mice, we examined the effect of DMSO on spontaneous motor activity and spatial learning and orientation ability. The acute effect of DMSO was studied in mice aged 3, 6, 9 and 22 weeks. DMSO treatment decreased spontaneous activity in the open field and swimming speed in the Morris water maze in both Lurcher mutant and wild type mice. While saline-treated Lurcher mice showed age-related decline of spatial memory in the Morris water maze in DMSO-treated ones such decline did not occur. The mechanism of the effect of DMSO remains unclear. A possible explanation could be modulation of the brain perfusion and metabolism in the aging brain. The improvement of learning ability could be also mediated by a tranquilizing effect of DMSO reducing stress-induced behavioral disinhibition which is supposed to interfere with learning process in Lurcher mutants. Future studies which would investigate DMSO effects in other models of neurodegenerative diseases are necessary to verify its potential therapeutic impact. DMSO has been many times described as harmless substance, beneficial in various diseases or pathological states, including brain injury or ischemia. Using Lurcher mutant mice suffering from genetically determined olivocerebellar degeneration and normal wild type mice, we examined the effect of DMSO on spontaneous motor activity and spatial learning and orientation ability. The acute effect of DMSO was studied in mice aged 3, 6, 9 and 22 weeks. DMSO treatment decreased spontaneous activity in the open field and swimming speed in the Morris water maze in both Lurcher mutant and wild type mice. While saline-treated Lurcher mice showed age-related decline of spatial memory in the Morris water maze in DMSO-treated ones such decline did not occur. The mechanism of the effect of DMSO remains unclear. A possible explanation could be modulation of the brain perfusion and metabolism in the aging brain. The improvement of learning ability could be also mediated by a tranquilizing effect of DMSO reducing stress-induced behavioral disinhibition which is supposed to interfere with learning process in Lurcher mutants. Future studies which would investigate DMSO effects in other models of neurodegenerative diseases are necessary to verify its potential therapeutic impact.
dcterms:title
Effect of dimethyl sulfoxide in cerebellar mutant Lurcher mice Effect of dimethyl sulfoxide in cerebellar mutant Lurcher mice
skos:prefLabel
Effect of dimethyl sulfoxide in cerebellar mutant Lurcher mice Effect of dimethyl sulfoxide in cerebellar mutant Lurcher mice
skos:notation
RIV/00216208:11140/13:10138961!RIV14-MSM-11140___
n10:predkladatel
n11:orjk%3A11140
n4:aktivita
n21:P n21:I
n4:aktivity
I, P(ED2.1.00/03.0076)
n4:cisloPeriodika
may
n4:dodaniDat
n14:2014
n4:domaciTvurceVysledku
n13:5778344 n13:6646948 n13:6134211
n4:druhVysledku
n20:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n6:predkladatel
n4:idSjednocenehoVysledku
71472
n4:idVysledku
RIV/00216208:11140/13:10138961
n4:jazykVysledku
n9:eng
n4:klicovaSlova
Spatial orientation; Olivocerebellar degeneration; Lurcher mouse; Dimethyl sulfoxide
n4:klicoveSlovo
n5:Spatial%20orientation n5:Dimethyl%20sulfoxide n5:Olivocerebellar%20degeneration n5:Lurcher%20mouse
n4:kodStatuVydavatele
IE - Irsko
n4:kontrolniKodProRIV
[B31862F29902]
n4:nazevZdroje
Neuroscience Letters
n4:obor
n16:FH
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
3
n4:projekt
n18:ED2.1.00%2F03.0076
n4:rokUplatneniVysledku
n14:2013
n4:svazekPeriodika
543
n4:tvurceVysledku
Cendelín, Jan Vožeh, František Markvartová, Věra
n4:wos
000319646000028
s:issn
0304-3940
s:numberOfPages
4
n19:doi
10.1016/j.neulet.2013.03.034
n3:organizacniJednotka
11140