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Statements

Subject Item
n2:RIV%2F00216208%3A11140%2F12%3A10128113%21RIV13-MSM-11140___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
The review summarizes the new findings in salivary gland pathology with particular reference to molecular genetic developments. In particular, newly recognized entities and specific chromosomal translocations associated with salivary gland carcinomas are discussed. Firstly, there are three types of salivary gland carcinomas which harbour important oncogenic translocations: mucoepidermoid carcinoma with the translocation t(11; 19)(q21; p13) CRTC1-MAML2 (as well as several other less frequent ones), adenoid cystic carcinoma with the translocation t(6; 9)(q22-23; p23-24) MYB-NFIB, and the recently described entity of mammary analogue secretory carcinoma (MASC) characterized by the translocation t(12; 15)(p13; q25) ETV6-NTRK3. Secondly, sclerosing polycystic adenosis was described in 1996 as possibly a salivary counterpart to benign fibrocystic disease of the breast, but recent molecular evidence of clonality suggests it is neoplastic in nature. Finally, new molecular developments in salivary duct carcinoma and molecular mechanisms responsible for high grade transformation and tumour progression in other neoplasms will be addressed. The review summarizes the new findings in salivary gland pathology with particular reference to molecular genetic developments. In particular, newly recognized entities and specific chromosomal translocations associated with salivary gland carcinomas are discussed. Firstly, there are three types of salivary gland carcinomas which harbour important oncogenic translocations: mucoepidermoid carcinoma with the translocation t(11; 19)(q21; p13) CRTC1-MAML2 (as well as several other less frequent ones), adenoid cystic carcinoma with the translocation t(6; 9)(q22-23; p23-24) MYB-NFIB, and the recently described entity of mammary analogue secretory carcinoma (MASC) characterized by the translocation t(12; 15)(p13; q25) ETV6-NTRK3. Secondly, sclerosing polycystic adenosis was described in 1996 as possibly a salivary counterpart to benign fibrocystic disease of the breast, but recent molecular evidence of clonality suggests it is neoplastic in nature. Finally, new molecular developments in salivary duct carcinoma and molecular mechanisms responsible for high grade transformation and tumour progression in other neoplasms will be addressed.
dcterms:title
Molecular advances in salivary gland pathology and their practical application Molecular advances in salivary gland pathology and their practical application
skos:prefLabel
Molecular advances in salivary gland pathology and their practical application Molecular advances in salivary gland pathology and their practical application
skos:notation
RIV/00216208:11140/12:10128113!RIV13-MSM-11140___
n8:predkladatel
n19:orjk%3A11140
n3:aktivita
n6:I
n3:aktivity
I
n3:cisloPeriodika
9
n3:dodaniDat
n11:2013
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n12:7629990 n12:7211139 n12:3631192
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n7:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
151519
n3:idVysledku
RIV/00216208:11140/12:10128113
n3:jazykVysledku
n9:eng
n3:klicovaSlova
salivary gland; MYB-NFIB translocation; mucoepidermoid carcinoma; mammary analogue secretory carcinoma; ETV6-NTRK3; CRTC1-MAML2; Adenoid cystic carcinoma
n3:klicoveSlovo
n4:salivary%20gland n4:Adenoid%20cystic%20carcinoma n4:mammary%20analogue%20secretory%20carcinoma n4:ETV6-NTRK3 n4:CRTC1-MAML2 n4:MYB-NFIB%20translocation n4:mucoepidermoid%20carcinoma
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[533280A3FEC9]
n3:nazevZdroje
Diagnostic Histopathology
n3:obor
n17:FP
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n11:2012
n3:svazekPeriodika
18
n3:tvurceVysledku
Vaněček, Tomáš Michal, Michal Simpson, Roderick HW Skálová, Alena
s:issn
1756-2317
s:numberOfPages
9
n13:doi
10.1016/j.mpdhp.2012.08.002
n15:organizacniJednotka
11140