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Statements

Subject Item
n2:RIV%2F00216208%3A11140%2F12%3A10126555%21RIV13-MSM-11140___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Chemotherapy is an important modality of treatment for non-small cell lung cancer (NSCLC). The aim of our study was to assess the relation of mRNA levels of DNA repair genes excision repair cross-complementary group 1 (ERCC1), ribonucleotide reductase subunit M1 (RRM1) and breast cancer 1 (BRCA1), in surgically-resected tumor tissues from patients who underwent adjuvant chemotherapy, to the disease-free interval (DFI) and overall survival (OS). We investigated if potential residual tumor cells after resection reflect properties of the primary tumor and response to chemotherapy according to the level of predictive markers with respect to current knowledge. We studied a group of 90 patients with NSCLC who had undergone curative lung resection. We found longer OS for patients with adenocarcinoma with higher expression of the RRM1 mRNA (p=0.002), and for patients with SCC with higher expression of the BRCA1 mRNA (p=0.041). In patients with NSCLC of stage III, we found longer DFI in those with higher expression of RRM1 (p=0.004) and ERCC1 (p=0.038). Patients who had been treated with adjuvant chemotherapy and had shown lower expression of repair genes had adverse prognosis. We observed that the assessment of DNA repair gene level in primary tumors treated by surgical resection had prognostic significance and did not predict response to adjuvant chemotherapy. Chemotherapy is an important modality of treatment for non-small cell lung cancer (NSCLC). The aim of our study was to assess the relation of mRNA levels of DNA repair genes excision repair cross-complementary group 1 (ERCC1), ribonucleotide reductase subunit M1 (RRM1) and breast cancer 1 (BRCA1), in surgically-resected tumor tissues from patients who underwent adjuvant chemotherapy, to the disease-free interval (DFI) and overall survival (OS). We investigated if potential residual tumor cells after resection reflect properties of the primary tumor and response to chemotherapy according to the level of predictive markers with respect to current knowledge. We studied a group of 90 patients with NSCLC who had undergone curative lung resection. We found longer OS for patients with adenocarcinoma with higher expression of the RRM1 mRNA (p=0.002), and for patients with SCC with higher expression of the BRCA1 mRNA (p=0.041). In patients with NSCLC of stage III, we found longer DFI in those with higher expression of RRM1 (p=0.004) and ERCC1 (p=0.038). Patients who had been treated with adjuvant chemotherapy and had shown lower expression of repair genes had adverse prognosis. We observed that the assessment of DNA repair gene level in primary tumors treated by surgical resection had prognostic significance and did not predict response to adjuvant chemotherapy.
dcterms:title
Prognostic significance of ERCC1, RRM1 and BRCA1 in surgically-treated patients with non-small cell lung cancer Prognostic significance of ERCC1, RRM1 and BRCA1 in surgically-treated patients with non-small cell lung cancer
skos:prefLabel
Prognostic significance of ERCC1, RRM1 and BRCA1 in surgically-treated patients with non-small cell lung cancer Prognostic significance of ERCC1, RRM1 and BRCA1 in surgically-treated patients with non-small cell lung cancer
skos:notation
RIV/00216208:11140/12:10126555!RIV13-MSM-11140___
n12:predkladatel
n16:orjk%3A11140
n3:aktivita
n14:S n14:I
n3:aktivity
I, S
n3:cisloPeriodika
11
n3:dodaniDat
n13:2013
n3:domaciTvurceVysledku
n5:2079526 n5:7080123 n5:4468694 n5:4249844 n5:6702007 n5:7725825 n5:6324339 n5:1821407
n3:druhVysledku
n9:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
162596
n3:idVysledku
RIV/00216208:11140/12:10126555
n3:jazykVysledku
n6:eng
n3:klicovaSlova
adjuvant chemotherapy; prognosis; BRCA1; RRM1; ERCC1; DNA repair genes; NSCLC
n3:klicoveSlovo
n4:NSCLC n4:ERCC1 n4:adjuvant%20chemotherapy n4:BRCA1 n4:prognosis n4:RRM1 n4:DNA%20repair%20genes
n3:kodStatuVydavatele
GR - Řecká republika
n3:kontrolniKodProRIV
[13C43C61785F]
n3:nazevZdroje
Anticancer Research
n3:obor
n10:EB
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n13:2012
n3:svazekPeriodika
32
n3:tvurceVysledku
Pešta, Martin Šafránek, Jarmil Černý, Radim Topolčan, Ondřej Kulda, Vlastimil Pešek, Miloš Krákorová, Gabriela Fiala, Ondřej
n3:wos
000311524500048
s:issn
0250-7005
s:numberOfPages
8
n18:organizacniJednotka
11140