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Statements

Subject Item
n2:RIV%2F00216208%3A11140%2F11%3A10106113%21RIV12-MZ0-11140___
rdf:type
skos:Concept n5:Vysledek
dcterms:description
TIMP-1 (tissue inhibitor of metalloproteinases 1) regulates not only extracellular matrix catabolism but the major effect in tumor tissue is promotion of cell growth and anti-apoptotic activity. The aim of our study was to evaluate TIMP-1 plasma levels and tissue TIMP-1 mRNA expression as a prognostic marker in NSCLC patients. Methods: We studied a group of 108 patients with NSCLC who had undergone lung surgery. Quantitative estimation analysis of TIMP-1 mRNA was performed using RT real-time PCR. Quantitative estimation of plasma TIMP-1 protein was performed using ELISA. Results: There was shorter disease free interval (DFI) in NSCLC patients at stage II with a higher expression of TIMP-1 mRNA in tumor tissue (p{0.0001). We found there to be a statisticaly significant relation between TIMP-1 mRNA tumor tissue expression and DFI in SCC (p{0.0001). We also found shorter overall survival (OS) in patients at stages IIIa + IIIb + IV with a higher expression of TIMP-1 mRNA (p=0.0389). We found statistically significant differences in TIMP-1 plasma levels between SCC and adenocarcinoma NSCLC patients (p=0.0491). We did not record any relationship between TIMP-1 plasma levels and prognosis (DFI, OS) in any studied group. Conclusion: We found there to be a relationship between TIMP-1 mRNA expression in NSCLC tumor tissue and prognosis. Higher tissue level of TIMP-1 is related to an adverse prognosis of patients. However, our results did not show the relation of TIMP-1 protein in blood plasma of patients with NSCLC to prognosis. TIMP-1 (tissue inhibitor of metalloproteinases 1) regulates not only extracellular matrix catabolism but the major effect in tumor tissue is promotion of cell growth and anti-apoptotic activity. The aim of our study was to evaluate TIMP-1 plasma levels and tissue TIMP-1 mRNA expression as a prognostic marker in NSCLC patients. Methods: We studied a group of 108 patients with NSCLC who had undergone lung surgery. Quantitative estimation analysis of TIMP-1 mRNA was performed using RT real-time PCR. Quantitative estimation of plasma TIMP-1 protein was performed using ELISA. Results: There was shorter disease free interval (DFI) in NSCLC patients at stage II with a higher expression of TIMP-1 mRNA in tumor tissue (p{0.0001). We found there to be a statisticaly significant relation between TIMP-1 mRNA tumor tissue expression and DFI in SCC (p{0.0001). We also found shorter overall survival (OS) in patients at stages IIIa + IIIb + IV with a higher expression of TIMP-1 mRNA (p=0.0389). We found statistically significant differences in TIMP-1 plasma levels between SCC and adenocarcinoma NSCLC patients (p=0.0491). We did not record any relationship between TIMP-1 plasma levels and prognosis (DFI, OS) in any studied group. Conclusion: We found there to be a relationship between TIMP-1 mRNA expression in NSCLC tumor tissue and prognosis. Higher tissue level of TIMP-1 is related to an adverse prognosis of patients. However, our results did not show the relation of TIMP-1 protein in blood plasma of patients with NSCLC to prognosis.
dcterms:title
Prognostic Significance of TIMP-1 in Non-small Cell Lung Cancer Prognostic Significance of TIMP-1 in Non-small Cell Lung Cancer
skos:prefLabel
Prognostic Significance of TIMP-1 in Non-small Cell Lung Cancer Prognostic Significance of TIMP-1 in Non-small Cell Lung Cancer
skos:notation
RIV/00216208:11140/11:10106113!RIV12-MZ0-11140___
n5:predkladatel
n6:orjk%3A11140
n3:aktivita
n11:Z n11:S n11:P
n3:aktivity
P(NS10230), S, Z(MSM0021620819)
n3:cisloPeriodika
11
n3:dodaniDat
n13:2012
n3:domaciTvurceVysledku
n4:4249844 n4:4394682 n4:6702007 n4:8931526 n4:8925860 n4:7747063 n4:6985521 n4:3838463 n4:2079526 n4:4256603 n4:7725825 n4:6324339 n4:3137643 n4:7368259
n3:druhVysledku
n15:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
224381
n3:idVysledku
RIV/00216208:11140/11:10106113
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Cancer; Lung; Cell; Non-small; TIMP-1; Significance; Prognostic
n3:klicoveSlovo
n16:Prognostic n16:TIMP-1 n16:Significance n16:Non-small n16:Cancer n16:Cell n16:Lung
n3:kodStatuVydavatele
GR - Řecká republika
n3:kontrolniKodProRIV
[D51738D1C1DF]
n3:nazevZdroje
Anticancer Research
n3:obor
n10:FD
n3:pocetDomacichTvurcuVysledku
14
n3:pocetTvurcuVysledku
14
n3:projekt
n7:NS10230
n3:rokUplatneniVysledku
n13:2011
n3:svazekPeriodika
31
n3:tvurceVysledku
Topolčan, Ondřej Vyčítal, Ondřej Brůha, Jan Kučera, Radek Kulda, Vlastimil Pešta, Martin Šafránek, Jarmil Třeška, Vladislav Vrzalová, Jindra Pešek, Miloš Holubec, Luboš Liška, Václav Pecen, Ladislav Pražáková, Markéta
n3:wos
000297482000056
n3:zamer
n19:MSM0021620819
s:issn
0250-7005
s:numberOfPages
8
n20:organizacniJednotka
11140